Sexual dysfunction associated with major depressive disorder and antidepressant treatment

Clayton, Anita H.; Haddad, Saria El; Iluonakhamhe, Josepha-Pearl; Martinez, Caridad Ponce; Schuck, Alexandra Elizabeth

doi:10.1517/14740338.2014.951324

Cited by 105 publications

(105 citation statements)

References 127 publications

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“…Several strategies have been investigated for the management of sexual dysfunction associated with antidepressants [for a review, see [106]]. For example, clinicians may attempt a switch to an antidepressant with a lower rate of sexual dysfunction.…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

“…The use of type 5 phosphodiesterase inhibitors (e.g. sildenafil, tadalafil and vardenafil) may also alleviate antidepressant-induced erectile dysfunction [106]. Finally, it is worth mentioning that for a small group of patients sexual dysfunction may either persist after treatment discontinuation or be a transitory phenomenon during AD treatment [110].…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Carvalho

Sharma²,

Brunoni³

et al. 2016

Psychother Psychosom

462

324

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Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later. They encompass gastrointestinal symptoms (nausea, diarrhea, gastric bleeding, dyspepsia), hepatotoxicity, weight gain and metabolic abnormalities, cardiovascular disturbances (heart rate, QT interval prolongation, hypertension, orthostatic hypotension), genitourinary symptoms (urinary retention, incontinence), sexual dysfunction, hyponatremia, osteoporosis and risk of fractures, bleeding, central nervous system disturbances (lowering of seizure threshold, extrapyramidal side effects, cognitive disturbances), sweating, sleep disturbances, affective disturbances (apathy, switches, paradoxical effects), ophthalmic manifestations (glaucoma, cataract) and hyperprolactinemia. At times, such adverse events may persist after drug discontinuation, yielding iatrogenic comorbidity. Other areas of concern involve suicidality, safety in overdose, discontinuation syndromes, risks during pregnancy and breast feeding, as well as risk of malignancies. Thus, the rational selection of ADs should consider the potential benefits and risks, likelihood of responsiveness to the treatment option and vulnerability to adverse events. The findings of this review should alert the physician to carefully review the appropriateness of AD prescription on an individual basis and to consider alternative treatments if available.

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Section: Sexual Dysfunctionmentioning

confidence: 99%

Section: Sexual Dysfunctionmentioning

confidence: 99%

The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature

Carvalho

Sharma²,

Brunoni³

et al. 2016

Psychother Psychosom

462

324

View full text Add to dashboard Cite

show abstract

“…Certain neurotransmitters and neurologic pathways have been implicated in the cause of antidepressant associated SD. Neurotransmitters like seretonin and dopamine has significant impact on sexual functioning, glutamate, nitric oxide, prolactin, and acetylcholine also seem to play a role [20].…”

Section: Pathophysiology Of Antidepressant Induced Sexual Dysfunctionmentioning

confidence: 99%

Sexual Dysfunctions in Depression

J¹,

Rao²,

Chandran³

et al. 2017

Clin Depress

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Sexual dysfunction is one of the common symptoms seen in depression. Presentations include decreased libido, erectile dysfunction, arousal difficulties and orgasm related dysfunctions. The probable causes of sexual dysfunction in such patients are complex and biological, psychological as well as psychosocial factors are likely to play an important role. Sexual dysfunction could also occur as an adverse effect of anti-depressants although it is difficult to establish whether the dysfunction is due to the illness or the medication. Awareness among professionals about sexual dysfunction is essential as it can have a profound impact in terms of relationship conflict, marital satisfaction, quality of life and compliance with treatment in patients with depression.

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“…The relationship between sexual dysfunction and depression is bidirectional, with sexual symptoms generally arising from neurobiologic changes that are related to the disorder itself (Clayton et al , 2014). …”

Section: Introductionmentioning

confidence: 99%