Sexual dysfunction among Nigerian women with epilepsy

Ogunjimi, Luqman; Yaria, Joseph; Makanjuola, Akintomiwa; Ogunniyi, A

doi:10.1016/j.yebeh.2018.02.004

Cited by 15 publications

(20 citation statements)

References 34 publications

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“…Especially temporolimbic epileptiform discharges might interrupt hypothalamic regulation of pituitary secretion. 32 Although some larger controlled studies did not look at seizure localization or lateralization, 10,11,13,15 rightsided temporal lobe epilepsy has been associated with a higher degree of sexual dysfunction. 33 In both the general population and among patients with epilepsy, it appears that seeking help from health care providers about sexual problems is uncommon, 2,9,34 and our results reiterate this.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13] Two further studies report no significant differences regarding sexual functioning between people with epilepsy and controls. 14,15 We have previously shown a significantly higher prevalence of sexual problems in women with epilepsy than in controls (75% vs 12%), and in men with epilepsy than in controls (63% vs 10%). 11 The large differences found in that study were probably due to selection bias, as the study included patients with severe epilepsy and a slightly different way of assessing sexual problems.…”

Section: Introductionmentioning

confidence: 96%

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Sexual function in people with epilepsy: Similarities and differences with the general population

et al. 2019

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Objective The potential impact of epilepsy on sexual function is important for patient welfare, but often neglected. This study explored the occurrences of different sexual problems in patients with both well‐controlled and mostly refractory epilepsy, and compared these with equivalent information from the general population. Methods Between 2015 and 2017, a total of 221 adult inpatients and outpatients, mostly with intractable epilepsy, at the National Centre for Epilepsy in Norway, and 78 outpatients with well‐controlled epilepsy at Lillehammer hospital participated in a questionnaire survey on sexual function. Information on the individual patient's epilepsy was collected. The results were compared with equivalent data on sexual function from 1671 adult Norwegians in the general population. Results Patients with epilepsy reported a significantly higher frequency of problems with orgasm, dyspareunia, erectile dysfunction, and feelings of sexual deviance. However, reduced sexual desire, premature ejaculation/climax, and vaginal dryness occurred at similar frequencies in the general population. After controlling for gender, we found no significant association between sexual problems and seizure control or use of enzyme‐inducing antiepileptic drugs. In both genders, feelings of sexual deviance were associated with lower quality of life. Fewer patients with epilepsy were satisfied with their sex lives. The perception of sex as an important part of daily life was similar among women with epilepsy and women from the general population, whereas significantly fewer men with epilepsy than men in the general population reported that sex was an important part of their daily lives. Women with mostly refractory epilepsy reported asking for help with their sexual problems significantly more often than women in the other groups. Significance Some sexual problems occur significantly more often in patients with epilepsy than in the general population and feelings of sexual deviancy occur more frequently. No epilepsy‐related factors could be identified as specific predictors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Sexual function in people with epilepsy: Similarities and differences with the general population

et al. 2019

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“…Both older age and feeling depressed are known to be associated with sexual problems in PWE. 26,27 As being in a relationship may provide patients with more opportunities for sexual activity, this may mean that any sexual problems are recognized more readily than in those living alone. In a study by Fisher et al, 6 32% of the patients reported living with a constant fear of the next seizure;…”

Section: Psychosocial Problemsmentioning

confidence: 99%

Challenges in epilepsy—The perspective of Norwegian epilepsy patients

et al. 2019

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Objectives For most people with epilepsy (PWE), problems that are not directly related to seizures may constitute major challenges in everyday life. The purpose of this study was to determine the extent of these challenges and any risk factors for their occurrence among PWE in Norway, based on the patients’ own perspective. Materials and Methods We used a web‐based survey to ask PWE visiting the homepage of the Norwegian Epilepsy Association about different everyday challenges. A link to the survey was accessible via the members’ homepage for a 4‐month period during 2017. Results One thousand one hundred eighty‐two PWE responded to the questionnaire. Although more than 40% of the cohort reported that they had been seizure free for at least 1 year, the majority reported that tiredness (71%), memory problems (70%), concentration problems (68%), headache or vertigo (51%), and feeling depressed (59%) continued to represent challenges. In addition, fear of being alone, sexual problems or difficulties in social settings were reported by about one‐third of the patients. Reporting having these challenges was significantly associated with female gender, polytherapy, experiencing seizures during the previous 12 months and feeling blue or depressed. Conclusions The results of this study, reflecting a self‐selected Norwegian population, provide insights into the challenges not directly associated with seizures that impact on the quality of life of PWE. The impacts of such challenges may be underestimated as components of the entire burden of epilepsy.

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“…Among them, 18 articles were excluded for failing to provide the control group; 8 articles for insufficient outcome data; 6 articles for not meeting the inclusion criteria; and 5 articles for inappropriate grouping. Finally, 9 observational studies [18][19][20][21][22][23][24][25][26] met the pre-defined eligibility criteria and were included in quantitative analysis. Fig.…”

Section: Literature Searchmentioning

confidence: 99%

“…Three studies referred to cross-sectional designed [21,23,25], five to case-control designed [18][19][20]22,26], and one study to cohort designed [24]. There were 2 publications conducted in Brazil [18,21] and United States [19,20], respectively, as well as 1 publication conducted in Italy [22], India [23], Norway [24], China [25], and Nigeria, respectively [26]. These included studies have enrolled a total of 1029 female participants and 527 male participants, of whom 418 women and 181 men were PWE, respectively.…”

Section: Study Characteristicmentioning

confidence: 99%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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A B S T R A C TPurpose: Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD. Methods: PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/ PROSPERO). Results: Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I 2 = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I 2 = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE. Conclusions: Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.

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Sexual dysfunction among Nigerian women with epilepsy

Cited by 15 publications

References 34 publications

Sexual function in people with epilepsy: Similarities and differences with the general population

Sexual function in people with epilepsy: Similarities and differences with the general population

Challenges in epilepsy—The perspective of Norwegian epilepsy patients

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

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