Sexual dimorphism of the planum temporale in schizophrenia: A MRI study

Delvecchio, Giuseppe; Pigoni, Alessandro; Perlini, Cinzia; Barillari, Marco; Ruggeri, Mirella; Altamura, Alfredo Carlo; Brambilla, Paolo

doi:10.1177/0004867417702748

Cited by 7 publications

(4 citation statements)

References 46 publications

(75 reference statements)

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“…However, in both schizophrenia and bipolar disorder, a diminished left-right hemispheric asymmetry for the 40Hz ASSRs has been shown (Teale et al 2003;Reite et al 2009;Tsuchimoto et al 2011). This is in line with an overall reduction of brain asymmetry on both the structural and functional level in neuropsychiatric disorders (Wang et al 2013;Ribolsi et al 2014;Royer et al 2015;Delvecchio et al 2017).…”

Section: Introductionsupporting

confidence: 60%

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

et al. 2017

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The 40 Hz auditory steady-state response (ASSR) is a periodic response to a periodic stimulation. Its sources are located in the primary auditory cortex and the asymmetry of the planum temporale has previously been associated with hand preference and gender-related differences; thus subject's handedness and gender could potentially influence ASSRs. Nevertheless, electrophysiological studies of ASSRs are mainly dominated by right-handed participants and the observed findings can only be generalized to the right-handed populations. However, for a potential use of 40 Hz ASSR as a translational biomarker of neuropsychiatric disorders, it is important to investigate the response in association to handedness and gender. We included an equal number of left-handed and right-handed males and females and recorded EEG responses during left-ear, right-ear and both ears stimulation. The results of the study suggest that the processing of 40 Hz auditory stimulation depends on the subjects' gender and handedness: significantly lower phase-locking and strength of 40 Hz ASSRs were observed in left-handed females as compared to left-handed males, but right-handers did not differ in 40 Hz ASSRs. Our observation of the opposite impact of gender in the examined handedness groups stresses the importance of careful consideration of handedness and gender factors when evaluating the determinants of inter individual variability of 40 Hz ASSRs. This finding is of particular importance for clinical studies in psychiatry and neurology.

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Section: Introductionsupporting

confidence: 60%

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

et al. 2017

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“…Possible explanations for these contrasting results could be related to the relative small sample size or to the presence of discrepancy between males and females within the patients or the control group. In this regard, it has been reported that genderrelated differences in brain structures have been often observed in several neuropsychiatric disorders, including schizophrenia (Ruigrok et al, 2014;Delvecchio et al, 2017b). Additionally, it might be also plausible that the different methodological approaches employed by the individual studies determined these inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining 39 FEP-NA patients who did not develop schizophrenia were diagnosed with: Acute transitory psychosis (n = 13), Non-organic, non-specific psychosis (n = 11), Persistent delusional psychotic syndrome (n = 7), Schizoaffective syndrome (n = 6), Acute delusional syndrome (n = 1), Acute psychosis with schizophrenic symptoms (n = 1). Patients with schizophrenia eligible for the study were selected by means of the South-Verona Psychiatric Care Register (PCR) (Tansella and Burti, 2003), a community-based mental health register, as previously reported in our publications (Delvecchio et al, 2017a(Delvecchio et al, , 2017bBrambilla et al, 2013aBrambilla et al, , 2013b. They had chronic illness.…”

Section: Participantsmentioning

confidence: 99%

Increased gyrification in schizophrenia and non affective first episode of psychosis

Zuliani

Delvecchio

Bonivento

et al. 2018

Schizophrenia Research

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“…Finally, the possibility that the healthy brain might also help us in shedding a light on brain disorders is also valid for the results observed in our group of male subjects. Indeed, GM abnormalities in the temporal gyri have been often associated with psychotic syndromes, especially with schizophrenia (Ohi et al, 2016;Delvecchio et al, 2017;Squarcina et al, 2017), which is a disorder where sexual dimorphism is well-described, with male individuals showing earlier onset, more severe course of the illness, and poorer long-term prognosis compared to matched females (Kelly et al, 2016).…”

Section: Age-related Gm Patterns In Malesmentioning

confidence: 99%

Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study

Delvecchio

Maggioni

Pigoni

et al. 2021

Front. Aging Neurosci.

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Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes.

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Sexual dimorphism of the planum temporale in schizophrenia: A MRI study

Abstract: Our results showed that sexual dimorphism plays a key role on planum temporale in schizophrenia, underlining the importance of gender as a modulator of brain morphology and lateralization of schizophrenia.

Cited by 7 publications

References 46 publications

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender

Increased gyrification in schizophrenia and non affective first episode of psychosis

Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study

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