Sexual dimorphism in the social behaviour ofCntnap2KO mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior cingulate cortex of males
Matt S. Dawson,
Kevin Gordon-Fleet,
Lingxin Yan
et al.
Abstract:A biological understanding of the apparent sex bias in autism is lacking. We have identified Cntnap2 KO mice as a model system to help better understand this dimorphism. Using this model, we observed social deficits in juvenile male KO mice only. These male-specific social deficits correlated with reduced spine densities of Layer 2/3 and Layer 5 pyramidal neurons in the Anterior Cingulate Cortex, a forebrain region prominently associated with the control of social behaviour. Furthermore, in male KO mice, micro… Show more
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