Sexual dimorphism in the neuronal circuits of the quail preoptic and limbic regions

Panzica, Giancarlo; Viglietti‐Panzica, C.; Balthazart, Jacques

doi:10.1002/jemt.1149

Cited by 34 publications

(18 citation statements)

References 65 publications

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“…The BSTm and SL are sexually dimorphic in terms of vasotocin-immunoreactive (VT-ir) cells and it has been speculated that steroid action within the BST, via afferents, could modulate the activity of neurons within the POM . Testosterone, following aromatization to estradiol, stimulates the expression of VT-ir material in neurons and fibers within the BSTm (Viglietti- Panzica et al, 2001). The high expression in the BSTm of ER mRNA compared with ER mRNA suggests that this stimulation might be mediated via ER.…”

Section: Discussionmentioning

confidence: 99%

Localization of estrogen receptor‐α and ‐βmRNA in brain areas controlling sexual behavior in Japanese quail

Halldin

Axelsson

Holmgren³

et al. 2005

J. Neurobiol.

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Two estrogen receptors (ERs), denoted ERalpha and ERbeta, have been identified in humans and various animal species, including the Japanese quail. Estrogens play a key role in sexual differentiation and in activation of sexual behavior in Japanese quail. The distribution of ERalpha in the brain of male and female adult quail has previously been studied using immunohistochemistry, whereas in situ hybridization has been employed to study the distribution of ERbeta mRNA in males only. In this article, we used in situ hybridization to study the distribution of mRNAs for both ERalpha and ERbeta in brain areas controlling sexual behavior of Japanese quail. Our results show that both ERalpha mRNA and ERbeta mRNA are localized in areas important for sexual behavior, such as the preoptic area and associated limbic areas, in both males and females. Moreover, we found differences in distribution of mRNA for the two receptors in these areas. The results of this article support previously reported data and provide novel data on localization of ER mRNAs in adult quail brain of both sexes.

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Section: Discussionmentioning

confidence: 99%

Localization of estrogen receptor‐α and ‐βmRNA in brain areas controlling sexual behavior in Japanese quail

Halldin

Axelsson

Holmgren³

et al. 2005

J. Neurobiol.

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“…In terms of connections, the medial BST (Panzica et al, 2001) was compared with the mammalian BSTMpl because of its connections with the preoptic hypothalamus (Absil et al, 2002), the premammilary area (Berk and Hawkin, 1985), and the pallial amygdala (Kroner and Güntürkün, 1999), although it lacks vomeronasal input and possesses only a sparse olfactory input (for review see Martínez-García et al, 2007). In addition, the lateral BST was seen to project to the parabrachial area (Wild et al, 1990) and to receive projections from the thalamus (Durand et al, 1992).…”

Section: Birdsmentioning

confidence: 98%

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Moreno

Morona

López

et al. 2011

J of Comparative Neurology

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Major common features have been reported for the organization of the basal telencephalon in amniotes, and most characteristics were thought to be acquired in the transition from anamniotes to amniotes. However, gene expression, neurochemical, and hodological data obtained for the basal ganglia and septal and amygdaloid complexes in amphibians (anamniotic tetrapods) have strengthened the idea of a conserved organization in tetrapods. A poorly characterized region in the forebrain of amniotes has been the bed nucleus of the stria terminalis (BST), but numerous recent investigations have characterized it as a member of the extended amygdala. Our study analyzes the main features of the BST in anuran amphibians to establish putative homologies with amniotes. Gene expression patterns during development identified the anuran BST as a subpallial, nonstriatal territory. The BST shows Nkx2.1 and Lhx7 expression and contains an Islet1-positive cell subpopulation derived from the lateral ganglionic eminence. Immunohistochemistry for diverse peptides and neurotransmitters revealed that the distinct chemoarchitecture of the BST is strongly conserved among tetrapods. In vitro tracing techniques with dextran amines revealed important connections between the BST and the central and medial amygdala, septal territories, medial pallium, preoptic area, lateral hypothalamus, thalamus, and prethalamus. The BST receives dopaminergic projections from the ventral tegmental area and is connected with the laterodorsal tegmental nucleus and the rostral raphe in the brainstem. All these data suggest that the anuran BST shares many features with its counterpart in amniotes and belongs to a basal continuum, likely controlling similar reflexes, reponses, and behaviors in tetrapods.

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“…The avian medial preoptic nucleus (POM) is functionally associated with the limbic areas lateral septum and the medial part of the bed nucleus of striae terminalis (BSTm) and these areas have a central role in the regulation of male sexual behavior (Balthazart et al, 1998). They have a sexually dimorphic vasotocinergic innervation, which is organized during embryogenesis by estrogens that presumably act via ERs in the brain (Panzica et al, 2001). The expression of the two ERs in the embryonic brain may therefore provide insight into their importance in differentiation of brain areas involved in sexual behavior.…”

Section: Introductionmentioning

confidence: 99%

Expression of estrogen receptor‐α and ‐β mRNA in the brain of Japanese quail embryos

Axelsson¹,

Mattsson²,

Brunström³

et al. 2007

Developmental Neurobiology

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The present study was conducted to investigate the mRNA expression of the two estrogen receptor (ER) subtypes ERalpha and ERbeta in the brain of Japanese quail embryos. We found expression of both ERalpha and ERbeta mRNA in homogenate of whole head from 6-day-old embryos, and in brain homogenate from 9- and 12-day-old embryos using real-time PCR. In 9- and 12-day-old embryos the ERalpha expression was higher in females than in males. We used in situ hybridization to examine the localization of the ERs in sections from male and female brains on day 9 and day 17 of incubation. On day 9, ERbeta mRNA was detected in the developing medial preoptic nucleus (POM), in the medial part of the bed nucleus of the striae terminalis (BSTm), and in the tuberal region of the hypothalamus. ERalpha signal could not be detected in the POM, the BSTm or the tuberal region in 9-day-old embryos. In 17-day-old embryos, ERbeta was highly expressed in the preoptic area, the nucleus Taeniae of the Amygdala (TnA) and the BSTm. Expression of ERalpha mRNA was detected in parts of the preoptic area and in the telencephalic TnA. No ERalpha expression was found in the BSTm, an area known to be sexually dimorphic in adults. The high embryonic expression of ERbeta in brain areas linked to sexual behavior indicates that ERbeta plays a role in sexual differentiation of the Japanese quail brain.

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Sexual dimorphism in the neuronal circuits of the quail preoptic and limbic regions

Cited by 34 publications

References 65 publications

Localization of estrogen receptor‐α and ‐βmRNA in brain areas controlling sexual behavior in Japanese quail

Localization of estrogen receptor‐α and ‐βmRNA in brain areas controlling sexual behavior in Japanese quail

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Expression of estrogen receptor‐α and ‐β mRNA in the brain of Japanese quail embryos

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