Sexual Dimorphism in Telomere Length in Childhood Autism

Panahi, Yasin; Moghaddam, Fahimeh Salasar; Babaei, Khadijeh; Eftekhar, Mohammad; Badv, Reza Shervin; Eskandari, Mohammad Reza; Vafaee-Shahi, Mohammad; Pezeshk, Hamid; Pedram, Mehrdad

doi:10.1007/s10803-022-05486-2

Cited by 2 publications

(1 citation statement)

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“…Up to 40% of children with ASD are diagnosed with genetic syndromes or chromosomal abnormalities, including small DNA deletions or duplications, genetic variants, and metabolic disorders with mitochondrial dysfunction, among others, all suggesting a genetic influence on ASD ( 10 ). In particular, chromosomal abnormalities are important in the pathogenesis of ASD, and the relative telomere length of chromosomes has a sexually dimorphic pattern in ASD, with boys with ASD having significantly shorter relative telomere lengths than typically developing controls and paired siblings ( 11 ). Numerous studies show many diseases resembling ASD-like phenotypes often involve chromosome 15q11-q13 segments ( 12 ).…”

Section: Genetic and Environmental Factorsmentioning

confidence: 99%

Neuroplasticity of children in autism spectrum disorder

Chen,

Wang,

Zhang

et al. 2024

Front. Psychiatry

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that encompasses a range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural and functional changes that occur in the nervous system to adapt and respond to changes in the external environment. In simpler terms, it is the brain’s ability to learn and adapt to new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory processing, and social cognition, leading to the manifestation of corresponding symptoms. This paper aims to review the current research progress on ASD neuroplasticity, focusing on genetics, environment, neural pathways, neuroinflammation, and immunity. The findings will provide a theoretical foundation and insights for intervention and treatment in pediatric fields related to ASD.

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Section: Genetic and Environmental Factorsmentioning

confidence: 99%