Sexual Dimorphism in Numbers of Vasotocin-Immunoreactive Neurons in Brain Areas Associated with Reproductive Behaviors in the Roughskin Newt

Moore, Frank L.; Richardson, Carla; Lowry, Christopher A.

doi:10.1006/gcen.1999.7424

Cited by 63 publications

(33 citation statements)

References 88 publications

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“…These observations together with the present findings strongly suggest that some of the behavioral effects of VP/VT and OT/MT could be mediated through modulation of neurosteroid-producing cell activity. In support of this hypothesis, several nuclei containing steroidogenic neurons in the frog telencephalon and diencephalon, including the lateral and medial amygdala, the anterior preoptic area, and the ventral hypothalamic nucleus are clearly involved in the regulation of male calling behavior (Boyd, 1997) and reproductive behavior (Zoeller and Moore, 1988;Moore et al, 2000) in amphibians.…”

Section: Pharmacological Characterization Of Vt and Mt Receptorsmentioning

confidence: 85%

Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain

do-Rego

Acharjee

Seong

et al. 2006

Journal of Neuroscience

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The stimulatory effect of VT and MT on neurosteroid biosynthesis was mimicked by VP and OT, as well as by a selective V1b receptor agonist, whereas V2 and OT receptor agonists had no effect. VT-induced neurosteroid production was completely suppressed by selective V1a receptor antagonists and was not affected by V2 and OT receptor antagonists. Concurrently, the effect of MT on neurosteroidogenesis was markedly attenuated by selective OT and V1a receptor antagonists but not by a V2 antagonist. The present study provides the first evidence for a regulatory effect of VT and MT on neurosteroid biosynthesis. These data suggest that neurosteroids may mediate some of the behavioral actions of VT and MT.

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Section: Pharmacological Characterization Of Vt and Mt Receptorsmentioning

confidence: 85%

Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain

do-Rego

Acharjee

Seong

et al. 2006

Journal of Neuroscience

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“…Concurrently, it has been shown that VT is expressed in chromaffin cells in the frog adrenal gland and that synthetic VT stimulates steroid secretion by frog adrenocortical cells (Larcher et al 1989(Larcher et al , 1992a(Larcher et al , 1992b. There is also clear evidence that VT is involved in reproductive behavior in amphibians (Moore et al 2000, Rose & Moore 2002, and sexual dimorphism in the distribution of VT-containing neurons has been reported in the frog brain (Boyd et al 1992).…”

Section: Introductionmentioning

confidence: 93%

“…vocalization, male amplectic clasping behavior, and female sexual receptivity (Moore 1992, Boyd 1997. In this respect, the dense network of VT-containing fibers and the intense expression of VTR mRNA in the anterior preoptic area is of particular interest since this nucleus is clearly involved in the regulation of male calling behavior (Boyd 1997) and sexual activity (Moore et al 2000).…”

Section: Frog Vasotocin and Mesotocin Receptors · S Acharjee And Othementioning

confidence: 99%

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee

do-Rego

et al. 2004

Journal of Molecular Endocrinology

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The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Rana esculenta. The frog VTR and MTR cDNAs encode proteins of 419 and 384 amino acids respectively. Frog VTR exhibits a high degree of sequence identity with the mammalian AVP-1a (V1a) receptor while the frog MTR possesses a high degree of sequence identity with the mammalian OT receptor. Activation of VTR induced both c-fos promoter-and cAMP-responsive element (CRE)-driven transcriptional activities, while activation of MTR induced c-fos promoter-driven transcriptional activity but failed to evoke CRE-driven transcriptional activity, suggesting differential G protein coupling between VTR and MTR. The VTR exhibited the highest sensitivity for VT followed by OT.AVP

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“…This region is marked by Lhx1/5, Lhx 2/9, Lhx5, and Lhx7 expression during development . This region also contains substance P and enkephalin fibers (Table 2) (Marin et al, 1998b) as well as a group of sexually dimorphic AVT neurons (González and Smeets, 1992;Moore et al, 2000), but only sparse neuropeptide Y immunoreactivity (Marin et al, 1998b). The amphibian BNST shares many similar hodological characteristics with the mammalian BNST, including reciprocal connections to the hypothalamus and HIP (Neary and Wilczynski, 1977;Allison and Wilczynski, 1991;Northcutt and Ronan, 1992;Neary, 1995).…”

Section: Amphibiansmentioning

confidence: 99%

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

849

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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Sexual Dimorphism in Numbers of Vasotocin-Immunoreactive Neurons in Brain Areas Associated with Reproductive Behaviors in the Roughskin Newt

Cited by 63 publications

References 88 publications

Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain

Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

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