Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: A possible mechanism for gender-based differences in endotoxic shock susceptibility

Marriott, Ian; Bost, Kenneth L.; Huet-Hudson, Yvette M.

doi:10.1016/j.jri.2006.01.004

Cited by 157 publications

(130 citation statements)

References 48 publications

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“…Despite the seeming reality of the observations, its reasons remain unclear. Gender-based differences in septic responses have been proven recently (40)(41)(42)(43). However, we do not have any evidence to show that different Aeromonas bacteremic types are associated with different gender-based septic responses.…”

Section: Discussioncontrasting

confidence: 58%

Different Clinical Characteristics between Polymicrobial and Monomicrobial Aeromonas Bacteremia -A Study of 216 Cases

Lay

Zhuang

et al. 2010

Intern. Med.

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Background Part of Aeromonas bacteremia is polymicrobial infection. However, a clinical comparison of monomicrobial and polymicrobial Aeromonas bacteremia has not hitherto been reported. Methods A retrospective analysis of medical records of patients with Aeromonas bacteremia at three large referral hospitals in Taiwan for an 8-year period (2001-2008) was conducted. Results There were 154 patients with monomicrobial Aeromonas bacteremia and 62 patients with polymicrobial Aeromonas bacteremia. In the polymicrobial infections, E. coli was the most common combined pathogen (42%), followed by Klebsiella spp. (24%) and Enterobacter spp. (16%). Multivariate logistic regression analysis revealed solid cancer as the risk factor for polymicrobial Aeromonas bacteremia, with male gender and cirrhosis as risk factors for monomicrobial Aeromonas bacteremia. However, of all types of solid cancer, hepatoma was associated with monomicrobial Aeromonas bacteremia. APACHE II score was the most important prognostic factor in both groups. Conclusion Aeromonas bacteremia in patients with cirrhosis or male gender tended to be monomicrobial. Polymicrobial Aeromonas bacteremia was associated with solid cancers. In either polymicrobial or monomicrobial Aeromonas bacteremia, prognosis could be predicted according to disease severity measured by APACHE II score.

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Section: Discussioncontrasting

confidence: 58%

Different Clinical Characteristics between Polymicrobial and Monomicrobial Aeromonas Bacteremia -A Study of 216 Cases

Lay

Zhuang

et al. 2010

Intern. Med.

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“…In our studies there was an observable, hormone-independent, dimorphism in male and female myeloid cells based on ex vivo culture studies and competitive BMT results, finding that male myeloid cells are more activated and proinflammatory. This phenomenon of sexually dimorphic inflammatory responses has been under investigated, but studies have demonstrated lower systemic LPS responses in females (27). Contrary to this, Calippe et al (3) showed that estradiol promotes proinflammatory cytokines via ER␣ activation on macrophages after ovariectomy.…”

Section: Discussionmentioning

confidence: 99%

Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity

Griffin

Lanzetta

Eter

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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Most murine studies are skewed toward the use of male mice to study obesity-induced metabolic dysfunction because of similar protection in female mice. We have investigated dietary obesity in a mouse model and have directly compared inflammatory responses in males and females. In this review we will summarize what is known about sex differences in diet-induced inflammation and will summarize our data on this topic. It is clear that sex differences in high-fat diet-induced inflammatory activation are due to cell intrinsic differences in hematopoietic responses to obesogenic cues, but further research is needed to understand what leads to sexually dimorphic responses. diabetes; high-fat diet; myelopoisis; obesity; sexual dimorphism GLOBAL OBESITY RATES have risen drastically in the past several decades with around one in every three individuals currently categorized as obese (34). The overall incidence of obesityrelated diseases such as diabetes and cardiovascular disease (CVD) also continues to rise as a result (3a). Obesity manifests as the result of an imbalance of caloric intake and energy expenditure. A major contributing factor to the increase in obesity rates is an increase in the consumption of calorie-dense foods rich in saturated fatty acids (4). With increased consumption of high-fat foods, individuals accrue body fat and thus have an elevated risk of developing obesity-related diseases. In this brief review we will emphasize the effects of diet-induced obesity, focusing primarily on sexually dimorphic responses of high-fat diet (HFD) priming of the immune system. An individual's response to HFD is dependent on several factors including sex, age, and ethnicity. What has become increasingly striking is that there is a clear sexual dimorphism in obesity and diabetes rates. While obesity rates are higher in women (34), men have higher rates of cardiovascular disease (CVD) and Type 2 diabetes (30, 36), suggesting that females are protected from the adverse effects of obesity (30). This is of particular importance because when investigating diabetes and CVD, many preclinical studies have been performed in males alone, leaving gaps in our knowledge of sexually dimorphic responses to obesity (45). Therefore, guidelines and therapies are being created based on investigations in males but are being implemented in men and women (13).It is important to investigate males and females to understand the contributing factors to these sex-specific differences. Previous studies have focused on altered hormone environments, anatomical fat distribution (17, 19), and energy expenditure differences. Women have been found to have 10% higher total body fat content compared with males of the same body mass index (BMI) (15). This dimorphism is especially profound in poor socioeconomic conditions, whereas richer environments show a smaller variance in adiposity between the sexes (11). This suggests that estrogen largely influences fat accumulation regardless of socioeconomic status (11). Additionally, when adiposity matched, fema...

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“…For example, serum APN levels are increased by aging in female, but not male, mice [19]. In addition, the changes in cytokine production caused by LPS-induced sepsis have also been reported to exhibit sexual dimorphism [27]. Therefore, it is possible that the system regulating APN expression and its anti-inflammatory role might differ slightly between the sexes.…”

Section: Effects Of Lps Injection On the Hypothalamic Mrna Expressionmentioning

confidence: 99%

The effects of LPS-induced endotoxemia on the expression of adiponectin and its receptors in female rats

et al. 2014

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Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: A possible mechanism for gender-based differences in endotoxic shock susceptibility

Cited by 157 publications

References 48 publications

Different Clinical Characteristics between Polymicrobial and Monomicrobial Aeromonas Bacteremia -A Study of 216 Cases

Different Clinical Characteristics between Polymicrobial and Monomicrobial Aeromonas Bacteremia -A Study of 216 Cases

Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity

The effects of LPS-induced endotoxemia on the expression of adiponectin and its receptors in female rats

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