Sexual differentiation and reproductive development of female rat offspring after paternal exposure to the anti-tumor pharmaceutical cisplatin

Silva, Patrícia V.; Silva, Raquel Frenedoso da; Borges, Cibele dos Santos; Cavariani, Marília Martins; Francia, Camila Contin Diniz de Almeida; Júnior, Fernando Barbosa; Kempinas, Wilma De Grava

doi:10.1016/j.reprotox.2016.02.005

Cited by 11 publications

(12 citation statements)

References 66 publications

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“…The female offspring displayed a decrease in the number of germ cells in foetal ovaries, a decline of serum concentration of FSH, and dysregulation in the estrous cyclicity at adulthood. However, puberty onset, sexual behaviour, and fertility were not affected by paternal exposure to cisplatin [148]. Moreover, paternal exposure to cisplatin during peri-puberty influenced the timing of testicular descent, epididymal sperm counts, and testicular histology in the rat male offspring.…”

Section: Effects Of Chemotherapy On Cancer Survivors' Offspringmentioning

confidence: 87%

“…FSH: follicle stimulating hormone, LH: luteinizing hormone, SSC: spermatogonial stem cell. [24][25][26][27][28][29][30]77,81,83], spermatogonia and spermatocytes [24,43,[46][47][48]52,53,55,89,[96][97][98], spermatozoa [56,62,98,[108][109][110][111]125,126,[129][130][131]135,136] and progeny [55,[109][110][111][143][144][145][146][147][148][149]151] following chemotherapy administration during childhood and adulthood. Animal species and the age at which the chemotherapy treatments achieved are specified in parentheses.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

Delessard

Saulnier

Rives

et al. 2020

IJMS

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Over the last decade, the number of cancer survivors has increased thanks to progress in diagnosis and treatment. Cancer treatments are often accompanied by adverse side effects depending on the age of the patient, the type of cancer, the treatment regimen, and the doses. The testicular tissue is very sensitive to chemotherapy and radiotherapy. This review will summarize the epidemiological and experimental data concerning the consequences of exposure to chemotherapy during the prepubertal period or adulthood on spermatogenic progression, sperm production, sperm nuclear quality, and the health of the offspring. Studies concerning the gonadotoxicity of anticancer drugs in adult survivors of childhood cancer are still limited compared with those concerning the effects of chemotherapy exposure during adulthood. In humans, it is difficult to evaluate exactly the toxicity of chemotherapeutic agents because cancer treatments often combine chemotherapy and radiotherapy. Thus, it is important to undertake experimental studies in animal models in order to define the mechanism involved in the drug gonadotoxicity and to assess the effects of their administration alone or in combination on immature and mature testis. These data will help to better inform cancer patients after recovery about the risks of chemotherapy for their future fertility and to propose fertility preservation options.

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Section: Effects Of Chemotherapy On Cancer Survivors' Offspringmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

Delessard

Saulnier

Rives

et al. 2020

IJMS

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“…The ovarian analysis was performed by observing the histological aspect of this organ and by counting the number of corpora lutea and follicles in the different stages of follicular development, as described by Talsness et al ( Talsness et al, 2005 ) and Guerra et al ( Guerra et al, 2014 ). In the uterine sections, the heights of perimetrium, myometrium, endometrium, and luminal epithelium were measured, as described by Silva et al ( e Silva et al, 2016 ). General histological and histopathological aspects of ovaries and uteri were assessed qualitatively, based on the guidelines described by Dixon et al ( Dixon et al, 2014 ).…”

Section: Methodsmentioning

confidence: 99%

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Barros

Tonon

Borges

et al. 2020

Current Research in Toxicology

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“…Several studies reported sperm epigenetic changes compromising embryo development or causing diseases later in life, such as reproductive disorders (Favareto et al, 2011;Ly et al, 2017;Schagdarsurengin and Steger, 2016;Silva et al, 2016;Stuppia et al, 2015). Previous study has associated increased DNA damage caused by oxidative stress with aberrant global methylation (Rajender et al, 2011).…”

Section: Sperm Morphology (%)mentioning

confidence: 99%

“…Moreover, various studies have shown that parental exposure to an endocrine disruptor may compromise reproduction of the exposed animals, as well as, affect reproductive function of the male or female offspring from the exposed animals even for two subsequent generations (Favareto et al, 2011;Schagdarsurengin and Steger, 2016;Silva et al, 2016;Zhao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty

Leite

Figueiredo

Guerra

et al. 2018

Food and Chemical Toxicology

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Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid by gavage from post-natal day (PND)23 until PND53. Rats were maintained until adulthood and mated with nulliparous females to obtain the male offspring, whose animals were evaluated at adulthood in relation to reproductive parameters. This study is a follow up of a previous paper addressing potential effects on F0 generation only (Leite et al., 2017). Male offspring from rosuvastatin-exposed groups showed increased sperm DNA fragmentation, androgen depletion and impairment on the testicular and epididymal structure. Ascorbic acid coadministered to the fathers ameliorated the reproductive damage in the offspring. In summary, paternal exposure to rosuvastatin may affect the reproduction in the male offspring; however, paternal supplementation with ascorbic acid was able to reduce the reproductive impairment in the male offspring caused by statin treatment to the fathers.

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Sexual differentiation and reproductive development of female rat offspring after paternal exposure to the anti-tumor pharmaceutical cisplatin

Cited by 11 publications

References 66 publications

Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty

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