Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice

Živković, Irena; Bufan, Biljana; Petrušić, Vladimir; Minić, Rajna; Arsenović-Ranin, Nevena; Petrović, Raisa; Leposavić, Gordana

doi:10.1016/j.vaccine.2015.09.006

Cited by 28 publications

(24 citation statements)

References 41 publications

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“…For example, females infected with human cytomegalovirus (HCMV) elicit higher levels of IgG3, our most functional antibody subclass, compared to men [ 73 ]. Female mice immunized with whole-virus trivalent inactivated influenza vaccine (TIV) generate a more robust IgG2a (most functional) response compared to male mice that generate a more balanced IgG2a/IgG1 subclass response [ 74 ]. Additionally, female mice also generate a more robust IgM response than males [ 74 ].…”

Section: Innate and Adaptive Immune Response Differences Across The Smentioning

confidence: 99%

“…Female mice immunized with whole-virus trivalent inactivated influenza vaccine (TIV) generate a more robust IgG2a (most functional) response compared to male mice that generate a more balanced IgG2a/IgG1 subclass response [ 74 ]. Additionally, female mice also generate a more robust IgM response than males [ 74 ]. Along the same lines, IgG subclass profiles in humans against pertussis toxin (PT) and filamentous hemagglutinin (FHA) following pertussis vaccination show higher levels of the poorly functional IgG4 antibody subclass among antigen-specific responses in men [ 75 ].…”

Section: Innate and Adaptive Immune Response Differences Across The Smentioning

confidence: 99%

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Sex differences in vaccine-induced humoral immunity

et al. 2018

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Vaccines are among the most impactful public health interventions, preventing millions of new infections and deaths annually worldwide. However, emerging data suggest that vaccines may not protect all populations equally. Specifically, studies analyzing variation in vaccine-induced immunity have pointed to the critical impact of genetics, the environment, nutrition, the microbiome, and sex in influencing vaccine responsiveness. The significant contribution of sex to modulating vaccine-induced immunity has gained attention over the last years. Specifically, females typically develop higher antibody responses and experience more adverse events following vaccination than males. This enhanced immune reactogenicity among females is thought to render females more resistant to infectious diseases, but conversely also contribute to higher incidence of autoimmunity among women. Dissection of mechanisms which underlie sex differences in vaccine-induced immunity has implicated hormonal, genetic, and microbiota differences across males and females. This review will highlight the importance of sex-dependent differences in vaccine-induced immunity and specifically will address the role of sex as a modulator of humoral immunity, key to long-term pathogen-specific protection.

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Section: Innate and Adaptive Immune Response Differences Across The Smentioning

confidence: 99%

Section: Innate and Adaptive Immune Response Differences Across The Smentioning

confidence: 99%

Sex differences in vaccine-induced humoral immunity

et al. 2018

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“…Among adults of reproductive ages (18-49 y), females have higher hemagglutination inhibition (HAI) and neutralizing antibody titers compared with males following receipt of the influenza trivalent inactivated vaccine (TIV) (6)(7)(8). In mice immunized with influenza TIV, females also generate higher neutralizing antibody responses to the H1N1 component of the vaccine than males (9). In mice immunized with live H1N1 or H3N2 viruses, adult females develop greater neutralizing antibody titers following vaccination (10).…”

mentioning

confidence: 99%

Biological sex affects vaccine efficacy and protection against influenza in mice

Fink

Engle

Ursin

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

193

207

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Biological sex affects adaptive immune responses, which could impact influenza infection and vaccine efficacy. Infection of mice with 2009 H1N1 induced antibody responses, CD4+ T cell and CD8+ T cell memory responses that were greater in females than males; both sexes, however, were equally protected against secondary challenge with an H1N1 drift variant virus. To test whether greater antibody in females is sufficient for protection against influenza, males and females were immunized with an inactivated H1N1 vaccine that induced predominantly antibody-mediated immunity. Following vaccination, females had greater antibody responses and protection against challenge with an H1N1 drift variant virus than males. Antibody derived from vaccinated females was better at protecting both naïve males and females than antibody from males, and this protection was associated with increased antibody specificity and avidity to the H1N1 virus. The expression of Tlr7 was greater in B cells from vaccinated females than males and was associated with reduced DNA methylation in the Tlr7 promoter region, higher neutralizing antibody, class switch recombination, and antibody avidity in females. Deletion of Tlr7 reduced sex differences in vaccine-induced antibody responses and protection following challenge and had a greater impact on responses in females than males. Taken together, these data illustrate that greater TLR7 activation and antibody production in females improves the efficacy of vaccination against influenza.

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“…The Th1 and Th2 cells are the two main subsets activated from the Th0 cell, and respond mainly in cellular immunity and humoral immunity, respectively [12,13]. It has been demonstrated that the skew in polarization is usually mutually restrictive [24][25][26], being closely dependent on the nature of the infectious agent and cytokines [14,25,27]. Studies have shown that the cross-talk between antigen-presenting cells and pathogens is decisive in the polarization of Th cells.…”

Section: Discussionmentioning

confidence: 99%

Diversity of Th1/Th2 immunity in mice with acute lung injury induced by the H1N1 influenza virus and lipopolysaccharides

Liu

Zhang

et al. 2019

J Infect Dev Ctries

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Introduction: The polarization of T helper (Th) cells plays an important role in the inflammatory response, pathogen removal, and tissue damage processes of infectious acute lung injury (ALI). However, Th cell polarization in viral-or bacterial-mediated ALI is not well defined. Herein, an influenza virus (A/FM/1/47, H1N1) and lipopolysaccharide (LPS) were chosen to induce ALI in mice, and the resultant diversity of Th-cell polarization was explored. Methodology: BALB/c mice were challenged intranasally with the influenza virus or LPS. Edema of the lung, infiltration of inflammatory cells (macrophages, neutrophils, and lymphocytes), oxidative stress, and signature cytokines of Th1 and Th2 cells were detected at 2 days post virus or LPS challenge. Results: The mice exhibited increased capillary permeability accompanied by lung edema and protein-rich alveolar exudation after virus or LPS challenge. Additionally, excessive infiltration of inflammatory cells, robust oxidative stress, and cytokine production were observed in both mouse groups. However, there was conspicuous disparity in the inflammatory cell infiltration and cytokines between the virus-and LPSchallenged mice, where the infiltration in virus-challenged mice was mainly of macrophages and accompanied by robust Th1 cytokine elevation, whereas the infiltration in LPS-challenged mice was primarily of neutrophils and accompanied by robust Th2 cytokine elevation. Conclusions: The Th cell polarization was skewed depending on whether ALI was induced by the influenza virus or LPS. The polarization in the virus-challenged mice was primarily toward a Th1 response, whereas that in the LPS-challenged mice was mainly toward Th2.

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Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice

Cited by 28 publications

References 41 publications

Sex differences in vaccine-induced humoral immunity

Sex differences in vaccine-induced humoral immunity

Biological sex affects vaccine efficacy and protection against influenza in mice

Diversity of Th1/Th2 immunity in mice with acute lung injury induced by the H1N1 influenza virus and lipopolysaccharides

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