Sexual desire and satisfaction after resective surgery in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Ramesha, K; Radhakrishnan, Ashalatha; Jiayaspathi, Ashwini; Padickaparambal, Sebastian; Alexander, Aley; Unnikrishnan, Janardhanan P.; Sarma, P. Sankara; Radhakrishnan, Kurupath

doi:10.1016/j.yebeh.2012.07.021

Cited by 15 publications

(3 citation statements)

References 37 publications

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“…A previous study [37] reported that anterior temporal lobectomy would result in postoperative seizure freedom in over 60% AED-resistant patients. Intriguingly, most patients who received the surgery have achieved an appreciable improvement in their sexual function postoperatively [38,39]. On the other hand, different types of Fig.…”

Section: Discussionmentioning

confidence: 99%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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A B S T R A C TPurpose: Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD. Methods: PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/ PROSPERO). Results: Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I 2 = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I 2 = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE. Conclusions: Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.

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Section: Discussionmentioning

confidence: 99%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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“… 30 Basically, the more one adopts the customary sex role of the opposite sex or conflicts with one's own sex and sex role, the higher the score is. According to Ramesha et al, 31 sexual dysfunction in male patients with MTLE caused by HS is common, but most of it is overlooked. Although some improvement is expected in the sexual dysfunction due to the reduction or disappearance of seizure frequency postoperatively, it is still considered to be inferior to the healthy control group.…”

Section: Discussionmentioning

confidence: 99%

“…30 Basically, the more one adopts the customary sex role of the opposite sex or conflicts with one's own sex and sex role, the higher the score is. According to Ramesha et al, 31 compared T-scores between the left and right TLE surgery and found no significant differences in any of the clinical scales. 6 Quigg et al 32 used the D scale of the MMPI in conjunction with the Clinical Depression Index (CDI) to investigate the relationship between the side of surgery and postoperative depression.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment may improve depressive and hysterical traits in temporal lobe epilepsy with hippocampal sclerosis: Study using the Minnesota Multiphasic Personality Inventory

Otabe,

Taniguchi,

Iijima

et al. 2024

PCN Reports

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AimThe influence of surgeries on psychiatric symptoms and personality traits is not well known in patients with intractable temporal lobe epilepsy (TLE). We investigated changes in personality traits with respect to postoperative seizure outcomes, etiology, side of surgery, and sex differences.MethodsClinical information was retrospectively collected for 44 patients whose Minnesota Multiphasic Personality Inventory (MMPI) was examined before and 1 year after surgical treatment for drug‐resistant TLE. Postoperative changes in MMPI T‐scores were analyzed using a paired t‐test. Participants were divided into two groups based on postoperative seizure outcome, the presence or absence of hippocampal sclerosis (HS) as the etiology, side of surgery, and sex differences. The effect of these clinical factors on postoperative changes in MMPI T‐scores was evaluated using analysis of covariance (P‐values < 0.05).ResultsThe hypochondria (Hs) scale decreased significantly in all patients (p = 0.022). The postoperative seizure‐free group had a significant decrease in the depression (D) scale (p = 0.037). The HS group had significant decreases in the D scale and the hysteria (Hy) scale (p = 0.016 and 0.004, respectively), and a significant increase in the masculinity‐femininity (Mf) scale (p = 0.009). No significant differences existed between the sides of surgery or sex.ConclusionDepressive traits were improved in patients with postoperative seizure freedom. Depressive and hysterical traits were improved in patients with HS, which may be attributed to a reduction in anxiety and fear associated with aura. Most personality traits are not significantly changed or exacerbated by surgical treatment of TLE.

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