Sexual behavior of male golden hamsters receiving diverse androgen treatment

Christensen, L. W.; Coniglio, Linda P.; Paup, Donald C.; Clemens, Lynwood G.

doi:10.1016/0018-506x(73)90006-8

Cited by 29 publications

(7 citation statements)

References 16 publications

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“…In the present experiment this conclusion is based on (i) data from sexually naive males whereas Whalen & DeBold used experienced ones (a condition which may ameliorate post-castration changes in sexual behaviour), and (ii) data obtained using a replacement dose of hormone (1-5 mg/week) substantially lower than that which Whalen & DeBold found necessary (1 mg/day). Both Whalen & DeBold (1974) and Christensen et al (1973) found androstenedione to be very effective at maintaining sexual behaviour, whereas here it was the least effective androgen. This is surprising because of its potency in facilitating aggression in the male hamster (Payne, 1974), but it does demonstrate that in this present experiment an aromatizable androgen was not as behaviourally potent as a non-aromatizable one.…”

Section: Discussionmentioning

confidence: 81%

“…In the golden hamster dihydrotestosterone can maintain aggressive be¬ haviour (Payne, 1974), but its effect on sexual behaviour is equivocal ; Christensen, Coniglio, Paup & Clemens (1973) found it ineffective, while Whalen & DeBold (1974) reported that it maintained intromission and ejaculatory responses, although not at as low a dosage as testosterone.…”

Section: Introductionmentioning

confidence: 95%

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Effects of androgens on sexual behaviour and somatic variables in the male golden hamster

Payne¹,

Bennett²

1976

Reproduction

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Comparisons were made of the sexual behaviour of sham-operated male hamsters and castrated males receiving testosterone, dihydrotestosterone or androstenedione (1-5 mg/week), or oil alone. Tests of short duration (10 min) were conducted at Week 3 (when the animals were sexually naive), Week 6 and Week 9. Sham-operated males showed marked increases in many elements of behaviour between Weeks 3 and 9, while castrated males receiving no androgen replacement showed marked decreases. Males receiving each of the three androgens showed marked increases in behaviour, but androstenedione-treated males showed less facilitation of sexual behaviour than controls. Dihydrotestosterone was as effective as testosterone. The three androgens were comparable in maintaining seminal vesicle weight after castration and in preventing the customary rise in pituitary and body weights. These data suggest that, unlike the situation in the rat, aromatization of androgens is unnecessary for the display of sexual behaviour in the hamster.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 95%

Effects of androgens on sexual behaviour and somatic variables in the male golden hamster

Payne¹,

Bennett²

1976

Reproduction

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“…Moreover, compounds which block the aromatization of androgens to oestrogens inhibit testosterone-induced mating behaviour in castrated rats (Christensen & Clemens, 1975;Morali, Larsson & Beyer, 1977) whilst this inhibition can be overcome by the concurrent administration of oestrogens (Morali et al 1977). Further evidence for the hypothesis that oestrogens are the agents responsible for inducing male mating behaviour has been provided by the demonstration that non-aromatizable an¬ drogens, such as 5a-dihydrotestosterone, are ineffective in eliciting mating behaviour in castrated rats (McDonald, Beyer, Newton, Brien, Baker, Tan, Sampson, Kitching, Greenhill & Pritchard, 1970;Parrott, 1975) and golden hamsters (Christensen, Coniglio, Paup & Clemens, 1973). In addition, several anti-oestrogens are able to prevent the behavioural response of castrated rats to testosterone treatment (Luttge, 1975;Beyer, Morali, Naftolin, Larsson & Pérez-Palacios, 1976).…”

Section: Introductionmentioning

confidence: 96%

Effects of Androgenic and Oestrogenic Hormones on Mating Behaviour in Rams Castrated Before or After Puberty

D’Occhio¹,

Brooks²

1980

Journal of Endocrinology

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Adult sheep which has been castrated either before or after puberty were treated with a variety of steroids. The administration of testosterone propionate, oestrone, oestradiol-17 beta or diethylstilboestrol to animals castrated before puberty caused them to mount oestrous ewes. Oestradiol-17 alpha was less effective than these hormones in this regard, whilst oestriol, hexoestrol and 5 alpha-dihydrotestosterone were ineffective. The response to oestradiol-17 beta was not altered by the concurrent administration of dexamethasone to block the pituitary-adrenal axis which suggests that oestradiol-17 beta was not exerting its effect indirectly by causing the release of adrenal steroids. When 5 alpha-dihydrotestosterone was administered in conjunction with oestradiol-17 beta intromission and ejaculation were observed in addition to mounting behaviour. When rams were castrated as adults their mating behaviour slowly declined over the course of 2 years. After this time, mounting behaviour was rapidly restored by the administration of oestradiol-17 beta but not by 5 alpha-dihydrotestosterone. These results are consistent with the hypothesis that oestrogens are the ultimate agents responsible for promoting mating behaviour in male animals and hence aromatizable androgens, such as testosterone, are effective whereas non-aromatizable androgens, such as 5 alpha-dihydrotestosterone, are not.

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“…DHT has been re ported to be no more effective than the oil control [6], to be significantly different from the oil control but not as effective as testosterone [31] and to be equal to testosterone for facilitation of mating behavior in the castrated ma!e [22].…”

mentioning

confidence: 99%

“…Testosterone propionate (TP) implants in the preoptic-anterior hypothalamus were found to be most effective in reactivating the complete pattern of male sex ual behavior. DHT implants in the anterior-hypothalamus preoptic area were significantly less effective than testos terone but more effective than cholesterol [II], Implants of E in the preoptic region were found to be more effective than similar implants of testosterone supporting the aromatization theory for the rat [6].…”

mentioning

confidence: 99%

Intrahypothalamic Hormone Implantation and Activation of Sexual Behavior in the Male Hamster

Lisk

Bezier²

1980

Neuroendocrinology

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Intrahypothalamic implants of testosterone propionate (TP), 5α-dihydrotestosterone (DHT) and estradiol (E) were compared for their effectiveness in reactivating sexual behavior of castrated male golden hamsters. Males tested preexperimentally and then observed for loss of sexual behavior responses after long-term castration were divided into four experimental treatment groups: anterior TP implants, DHT implants and E implants, and posterior TP implants. All animals were tested at 7 and 21 days postimplantation. On the day 7 implant test mount frequency, latency and duration per mount were significantly different from the castrate response for the TP implant groups. On the day 21 implant test both TP and E implant groups showed significant changes in mounting while intromission frequency, latency and duration per intromission were significantly different from the castrate only for the TP implant groups. DHT implants were not effective in reactivating any aspect of copulatory behavior in the castrate male hamster.

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Sexual behavior of male golden hamsters receiving diverse androgen treatment

Cited by 29 publications

References 16 publications

Effects of androgens on sexual behaviour and somatic variables in the male golden hamster

Effects of androgens on sexual behaviour and somatic variables in the male golden hamster

Effects of Androgenic and Oestrogenic Hormones on Mating Behaviour in Rams Castrated Before or After Puberty

Intrahypothalamic Hormone Implantation and Activation of Sexual Behavior in the Male Hamster

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