Sexual behavior in male rats after nitric oxide synthesis inhibition

Bialy, Michał; Beck, J; Abramczyk, Piotr; Trzebski, A; Przybylski, Jacek

doi:10.1016/0031-9384(95)02272-4

Cited by 48 publications

(36 citation statements)

References 26 publications

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“…Thus, although NO appears to be important for the initial acquisition of copulatory behavior, it may not be an absolute requirement for its maintenance. However, even sexually experienced rats in this and other studies have shown sexual deficits with systemically (Benelli et al, 1995;Bialy et al, 1996;Hull et al, 1994) or centrally (Melis et al, 1998;Sato et al, 1998Sato et al, , 1999 administered NOS inhibitors.…”

Section: Discussionmentioning

confidence: 45%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

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Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.

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Section: Discussionmentioning

confidence: 45%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

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“…Benelli et al, 1995;Bialy et al, 1996;Hull et al, 1994) nitric oxide (NO), in both basal and female-stimulated conditions (reviewed in Dominguez and Hull, 2005;Hull et al, 2006). NO synthase immunoreactivity (NOS-ir) is positively regulated by both T and E 2 (Du and Hull, 1999;Putnam et al, 2005).…”

Section: Ne Antagonists − (Clark and Smith 1990)mentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

392

272

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The hormonal factors and neural circuitry that control copulation are similar across rodent species, although there are differences in specific behavior patterns. Both estradiol (E) and dihydrotestosterone (DHT) contribute to the activation of mating, although E is more important for copulation and DHT for genital reflexes. Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Chemosensory inputs from the main and accessory olfactory systems are the most important stimuli for mating in rodents, especially in hamsters, although genitosensory input also contributes. Dopamine agonists facilitate sexual behavior, and serotonin (5-HT) is generally inhibitory, though certain 5-HT receptor subtypes facilitate erection or ejaculation. Norepinephrine agonists and opiates have dose-dependent effects, with low doses facilitating and high doses inhibiting behavior.

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“…Both NO donors and PDE5-i's are known to reduce the contractile response of human SVs, 23 to reverse postsynaptic contraction of isolated human SV with different potency 24 and to inhibit seminal emissions in rats, 25 whereas NOS inhibitors, such as L-NAME, decrease the latency to emission. 26 It is noteworthy that not only the bladder neck, urethra and prostate but also the SV and VD show a typical mRNA distribution for a-adrenoceptors, 27 which accounts for by their capacity to delay or abolish ejaculation reported in clinical studies in men with prostatic hyperplasia (up to 7% of cases reported with tamsulosin). It is supposed that ejaculatory disorders caused by selective a 1 A-adrenoceptor antagonists are not a result of retrograde ejaculation but a loss of seminal emission (dry ejaculation).…”

Section: Introductionmentioning

confidence: 99%

Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?

et al. 2011

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Premature ejaculation (PE) is considered to be the most common male sexual dysfunction. The realization that PE may co-exist with ED prompted the use of PDE5-i's alone or in combination with selective serotonin reuptake inhibitors (SSRIs) for treating ejaculatory disorders. Until recently, there was little evidence that PDE5-i's alone may have a role in the treatment of PE in the absence of ED, and current available treatments include only on-demand dapoxetine. However, available data indicate that there is clinical, anatomical, physiological, pharmacological and genetic evidence to explain the efficacy of PDE5-i's. Nine manuscripts that examined the efficacy of PDE5-i's in the treatment of PE, alone or in combination with SSRIs, were retrieved. All studies reported some significant changes in the intravaginal ejaculatory latency time and sexual satisfaction scores, although not all were clinically meaningful. Well-designed multicenter studies are urgently required to further elucidate the efficacy and safety, as well as the mechanisms of action of PDE5-i's in the treatment of PE. The aim of this review is to discuss basic rationale and to show clinical evidence sustaining the possibility to use off-label PDE5-i's to treat PE.

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Sexual behavior in male rats after nitric oxide synthesis inhibition

Cited by 48 publications

References 26 publications

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Sexual behavior in male rodents

Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?

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