Sex Steroids Regulation of Appetitive Behavior

Bautista, Claudia J.; Martínez-Samayoa, P. M.; Zambrano, Elena

doi:10.2174/138955712802762176

Cited by 11 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple peptides, like Leptin, Ghrelin, Cholecystokinin, and Glucagon-like peptide-1, are also found to be of different concentrations in blood between female and male mouse3536. Nevertheless, protein-specific satiety peptides have not been identified in vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

et al. 2017

View full text Add to dashboard Cite

Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake. Interestingly, Fit is a sexually dimorphic gene, and consequently protein consumption-induced insulin release, as well as protein feeding behaviour, are also dimorphic between sexes. Thus, our findings reveal a protein-specific satiety hormone, providing important insights into the complex regulation of feeding decision, as well as the sexual dimorphism in feeding behaviour.

show abstract

Section: Discussionmentioning

confidence: 99%

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The present results show the possibility that the reduced nesfatin-1/NUCB2 expression in the hypothalamus in response to testosterone, which is produced and secreted by the Leydig cells in testis, may contribute to feeding behavior in male and even in female mice. Testosterone has been known to influence appetite control and feeding behavior (Iwasa et al, 2016; Bautista et al, 2012). Hypothalamic mRNA levels of ERα, which plays pivotal roles in regulation of body weight and metabolism, were decreased by chronic testosterone administration in rats (Iwasa et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Estradiol has been known to inhibit feeding in rats with a reduction of food intake around the time of ovulation, when estradiol presents its highest levels. Men with higher testosterone levels compared to women accumulate more fat in the intraabdominal depot, suggesting that testosterone stimulates feeding (Bautista et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Testosterone Regulates NUCB2 mRNA Expression in Male Mouse Hypothalamus and Pituitary Gland

Seon¹,

Jeon²,

Kim³

et al. 2017

Dev Reprod

View full text Add to dashboard Cite

Nesfatin-1/NUCB2 is known to take part in the control of the appetite and energy metabolism. Recently, many reports have shown nesfatin-1/NUCB2 expression and function in various organs. We previously demonstrated that nesfatin-1/NUCB2 expression level is higher in the pituitary gland compared to other organs and its expression is regulated by 17β-estradiol and progesterone secreted from the ovary. However, currently no data exist on the expression of nesfatin-1/NUCB2 and its regulation mechanism in the pituitary of male mouse. Therefore, we examined whether nesfatin-1/NUCB2 is expressed in the male mouse pituitary and if its expression is regulated by testosterone. As a result of PCR and western blotting, we found that a large amount of nesfatin-1/NUCB2 was expressed in the pituitary and hypothalamus. The NUCB2 mRNA expression level in the pituitary was decreased after castration, but not in the hypothalamus. In addition, its mRNA expression level in the pituitary was increased after testosterone treatment in the castrated mice, whereas, the expression level in the hypothalamus was significantly decreased after the treatment with testosterone. The in vitro experiment to elucidate the direct effect of testosterone on NUCB2 mRNA expression showed that NUCB2 mRNA expression was significantly decreased with testosterone in cultured hypothalamus tissue, but increased with testosterone in cultured pituitary gland. The present study demonstrated that nesfatin-1/NUCB2 was highly expressed in the male mouse pituitary and was regulated by testosterone. This data suggests that reproductive-endocrine regulation through hypothalamus-pituitary-testis axis may contribute to NUCB2 mRNA expression in the mouse hypothalamus and pituitary gland.

show abstract

“…Central regulation of sexual behavior is complex and involves various neurotransmitter systems and/or neuropeptides [26,28,29,[33][34][35]37,38,[40][41][42][43][44][45]. It has been established that central dopamine is a key neurotransmitter in the control of sexual function [26,28,29,37,38,[40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Hypoxia Ischemia Increases Male Rat Sexual Behavior

Ferraz

Sab

Silva

et al. 2015

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction Research consistently indicates an association between prenatal hypoxia-ischemia (HI) and mortality and chronic neurological diseases in newborns. HI can cause permanent effects, including mental retardation, motor impairment, learning disabilities, epilepsy, and cerebral palsy. Moreover, little is known about the relationship between HI and sexual behavior. Aims The aims of this study are to examine whether HI is associated with changes in sexual behavior. Methods HI was induced by clamping the uterine arteries of pregnant rats. The arteries were clamped for 45 minutes on the 18th day of gestation (HI group). Shams received laparotomy and anesthesia only. Pups were born at term. At 90 days of age, sexual behavior was evaluated. Statistical analysis was performed using two-way analysis of variance and post hoc Bonferonni correction. Main Outcome Measures The main outcome measures of sexual response were standard sexual behavior, homosexual behavior, and sexual attempt on nonreceptive females. Results The stimulatory effect of HI on male rat sexual behavior has been shown in various experimental models; these animals showed reduced mount, intromission and ejaculation latencies; increased copulatory efficiency; and homosexual mounting. Additionally, there was an increase in fighting in trying to mount an unreceptive female. Conclusion Our results indicate that HI had a long-term effect on sexual behavior despite exhibiting motor skill impairment. Accordingly, injuries during the fetal period may cause behavioral problems in adulthood.

show abstract

Sex Steroids Regulation of Appetitive Behavior

Cited by 11 publications

References 0 publications

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Testosterone Regulates NUCB2 mRNA Expression in Male Mouse Hypothalamus and Pituitary Gland

Prenatal Hypoxia Ischemia Increases Male Rat Sexual Behavior

Contact Info

Product

Resources

About