Sex steroid profiles of coho salmon (Oncorhynchus kisutch) during early development and sexual differentiation

Feist, Grant W.; Schreck, Carl B.; Fitzpatrick, Martin S.; Redding, Joseph S.

doi:10.1016/0016-6480(90)90174-k

Cited by 176 publications

(98 citation statements)

References 22 publications

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“…The presence of sex steroid hormones in eggs before fertilization supports the idea that some sex steroids were maternally transferred into the eggs [8]. Sex steroids levels in stripped or unfertilised eggs could very be high, as observed in other fish species or in reptiles, suggesting a hormonal transmission from the female to the eggs [8,13,34].…”

Section: Discussionsupporting

confidence: 72%

“…Sex steroid hormones are principally synthesized in gonad, although non-gonadal tissues, such as brain, blood, kidney or liver, can also synthesize these hormones [10,14,19,35]. The detection or presence of significant levels of testosterone, estradiol and 11keto-testosterone in embryos and developing larvae of Eurasian perch before the histological differentiation of the gonad strongly suggest an extra-gonadal synthesis of these sex steroid hormones in Eurasian perch, as has been observed in Coho salmon [8] and tilapia [12].…”

Section: Discussionmentioning

confidence: 73%

“…Sex steroids levels in stripped or unfertilised eggs could very be high, as observed in other fish species or in reptiles, suggesting a hormonal transmission from the female to the eggs [8,13,34]. These ''maternal'' sex steroids could be used as precursors to induce the initial sexual differentiation of the brain and/or the gonads.…”

Section: Discussionmentioning

confidence: 89%

“…In fish, testosterone is not directly implicated in sexual differentiation mechanisms, but plays an intermediate role as precursor of 11-ketotestosterone and 17b-estradiol [2,9]. Nevertheless, in many species, testosterone seems to play an important role in sex differentiation and is closely related to gonadal differentiation [6,8,13,14,20]. In the present study, the testosterone peak observed at D30-D35 could be associated with the occurrence of sex differentiation in Eurasian perch [30], but as for other fish species, it was not possible to conclude if it is a cause or a consequence of gonadal differentiation [8,15,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…while 11KT (11-oxygenated androgen) is often considered as the main androgen involved in testis differentiation in teleosts [3,[7][8][9][10][11][12]. As testosterone is the hormonal precursor of 11KT and E2, its role in sexual differentiation is therefore of great importance and is generally reflected in the processes of sex differentiation [6,[13][14][15].…”

Section: A U T H O R ' S P E R S O N a L C O P Ymentioning

confidence: 99%

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Sex steroid dynamics during embryogenesis and sexual differentiation in Eurasian perch, Perca fluviatilis

et al. 2007

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It is widely accepted that sex steroid hormones play an important and a specific role during the process of sex differentiation in fish. In order to describe the role of the three main sex steroid hormones (testosterone-T, 17b-estradiol-E2 and 11keto-testosterone-11KT) during embryogenesis and sex differentiation in Eurasian perch, Perca fluviatilis, eggs, larvae and juveniles originating from two mixed-sex and two all-female progenies were regularly sampled from fertilization to hatching (D0) and from hatching to day 70 post-hatching (D70). Just after spawning, a significant amount of sex steroids [T (1634.2 pg g ) and significantly increased after the onset of the histological differentiation of the gonad in both progenies (D35). Levels of 11KT were significantly higher in mixed-sex (median: 431.5 pg g À1) than in all-female progenies (below the limit of assay detection) and significantly increased at D35 in all-female progenies (median value: 343.2 pg g À1 ). Mean 11KT to E2 ratio was six-fold higher in mixed-sex progenies (1.35) than in all-female progenies (0.24). The data suggest that the 11-oxygenated androgen (11KT) plays a major role in the male differentiation process, and that sex differentiation in Eurasian perch is probably determined by the 11KT to E2 ratio. #

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: A U T H O R ' S P E R S O N a L C O P Ymentioning

confidence: 99%

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Sex steroid dynamics during embryogenesis and sexual differentiation in Eurasian perch, Perca fluviatilis

et al. 2007

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Convenient method for sex reversal in a freshwater teleost, the medaka

Isobe

1999

J. Exp. Zool.

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Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene

et al. 2005

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Compared with adult mammals, the brain of teleost fish is characterized by an extremely high capacity to aromatize androgens into estrogens, and this metabolic activity results from the expression of a specific brain aromatase (AroB) generated by the cyp19b gene. In this study, we first generated antibodies to zebrafish AroB and used them to map AroB-positive structures in the brain of adult zebrafish. We show that AroB is exclusively expressed in radial glial cells, mainly in the olfactory bulbs, telencephalon, preoptic area, and hypothalamus. Second, we investigated in vivo and in vitro the mechanisms involved in the estradiol (E2) regulation of the cyp19b gene. By means of whole-mount hybridization and immunohistochemistry on zebrafish embryos and larvae, we confirmed the E2-dependent upregulation of the cyp19b gene, and we show that E2 triggers AroB expression in radial glial cells mainly in the preoptic area and mediobasal hypothalamus of 48 hpf (hours post fertilization) and 108 hpf larvae. In addition, an in vitro analysis of 0.5 kb of the promoter region of the cyp19b gene demonstrated that this E2-dependent regulation involves a direct transcriptional action of estrogen receptors requiring estrogen-responsive elements. However, the data obtained on different cell lines demonstrate that a glial cell context is necessary for full E2 induction. The correlation between our in vivo and in vitro data suggests that the E2-dependent upregulation of AroB is favored by a glial cell context.

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Sex steroid profiles of coho salmon (Oncorhynchus kisutch) during early development and sexual differentiation

Cited by 176 publications

References 22 publications

Sex steroid dynamics during embryogenesis and sexual differentiation in Eurasian perch, Perca fluviatilis

Sex steroid dynamics during embryogenesis and sexual differentiation in Eurasian perch, Perca fluviatilis

Convenient method for sex reversal in a freshwater teleost, the medaka

Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene

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