Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions

Ulloa, Pilar Cornejo; Krom, Bastiaan P.; Veen, Monique H. van der

doi:10.3389/fcimb.2021.714229

Cited by 21 publications

(19 citation statements)

References 103 publications

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“…In relation to periodontal health, the physiological and hormonal changes during pregnancy exhibit a direct impact on periodontal tissues [ 48 ]. P. intermedia and P. nigrescens can take up and utilize sex steroid hormones (estrogen and progesterone) as substitutes for vitamin K, the essential growth factor, in temperature- and concentration-dependent manners [ 49 ].…”

Section: Properties Of Oral Prevotella Organismsmentioning

confidence: 99%

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Könönen

Fteita

Gürsoy

et al. 2022

Journal of Oral Microbiology

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Oral Prevotella are known as anaerobic commensals on oral mucosae and in dental plaques from early life onwards, including pigmented P. melaninogenica, P. nigrescens, and P. pallens and non-pigmented Prevotella species. Many Prevotella species contribute to oral inflammatory processes, being frequent findings in dysbiotic biofilms of periodontal diseases ( P. intermedia, P. nigrescens ), cariotic lesions ( P. denticola, Alloprevotella (formerly Prevotella ) tannerae ), endodontic infections ( P. baroniae, P. oris, P. multisaccharivorax ), and other clinically relevant oral conditions. Over the years, several novel species have been recovered from the oral cavity without knowledge of their clinical relevance. Within this wide genus, virulence properties and other characteristics like biofilm formation seemingly vary in a species- and strain-dependent manner, as shown for the P. intermedia group organisms ( P. aurantiaca, P. intermedia, P. nigrescens , and P. pallens ). Oral Prevotella species are identified in various non-oral infections and chronic pathological conditions. Here, we have updated the knowledge of the genus Prevotella and the role of Prevotella species as residents and infectious agents of the oral cavity, as well as their detection in non-oral infections, but also gathered information on their potential link to cancers of the head and neck, and other systemic disorders.

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Section: Properties Of Oral Prevotella Organismsmentioning

confidence: 99%

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Könönen

Fteita

Gürsoy

et al. 2022

Journal of Oral Microbiology

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“…P. intermedia is closely related to periodontal disease ( Braga et al., 2010 ). In young women, due to fluctuations in SHH levels, the biological behavior of P. intermedia is also affected ( Fteita et al., 2014 ; Cornejo Ulloa et al., 2021 ). Estradiol enhances the toxicity of P. intermedia , which is related to one of its virulence factors: protease dipeptidyl peptidase IV ( Fteita et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sex steroid hormones (SHHs) are cholesterol-derived molecules secreted into saliva and which reach oral tissues such as the gums and periodontium ( Cornejo Ulloa et al., 2021 ). The prevalence and severity of periodontitis is lower in females in most age groups compared with those in males, which may be related to different SHH levels in males and females ( Albandar, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis

Zhao

Feng

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectivePeriodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified the dominant bacteria and the potential pathway in young women with stage-III periodontitis.Materials and methodsSamples of subgingival plaque were collected from 26 young women with periodontitis (20 with stage-I and 6 with stage-III). Using 16S rRNA-sequencing, we determined the variation in oral bacterial communities of the two groups, and identified the dominant bacteria of each group. We used the Kyoto Encyclopedia of Genes and Genomes (KEGG) database to evaluate the signaling pathways related to the difference in oral bacterial composition. The role of the dominant bacteria of stage-III periodontitis was investigated in vivo and in vitro using an endoplasmic reticulum stress inhibitor.ResultsYoung women with stage-I periodontitis had higher values for the Chao1 Index, Observed Species and Phylogenetic Diversity Whole Tree Index than those for women with stage-III periodontitis. β-diversity analyses revealed that samples could be divided into different groups according to the periodontitis stage. The most representative biomarkers of stage-III periodontitis in young women were bacteria of the phylum Bacteroidetes, its order, family and genera Bacteroidales, Prevotellaceae and Prevotella. The KEGG database revealed that the change in oral bacterial composition of young women with stage-III periodontitis may be related to protein processing in an endoplasmic reticulum pathway. Salubrinal (an endoplasmic reticulum stress regulator) controlled expression of Runx2, Col1a1, Ocn in mouse bone-marrow mesenchymal cells. Salubrinal administration showed that moderate endoplasmic reticulum stress inhibited alveolar bone loss in periodontitis induced by Prevotella intermedia lipopolysaccharide.ConclusionDifferences between periodontitis stages were noted and bacteria of Prevotella species were abundant in young women with stage-III periodontitis. This phenomenon was related to protein processing in an endoplasmic reticulum pathway.

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“…During pregnancy, the surge of hormonal levels triggers oral tissue responses ( Cornejo Ulloa et al, 2021 ), which means changes in the composition or abundance of oral microorganisms occur relative to postpartum or non-pregnant status. This shift may lead to a potentially more hazardous microbial community ( Zi et al, 2014 ).…”

Section: Pregnancy Alters the Progression Of Periodontal Diseasesmentioning

confidence: 99%

The bidirectional relationship between periodontal disease and pregnancy via the interaction of oral microorganisms, hormone and immune response

Wen

Fu²,

Zhao³

et al. 2023

Front. Microbiol.

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Periodontal disease has been suggested to be linked to adverse pregnancy outcomes such as preterm birth, low birth weight, and preeclampsia. Adverse pregnancy outcomes are a significant public health issue with important clinical and societal repercussions. This article systematically reviews the available epidemiological studies involving the relationship between periodontal disease and adverse pregnancy outcomes over the past 15 years, and finds a weak but independent association between adverse pregnancy outcomes and periodontal disease. The bidirectional association and the potential mechanisms are then explored, focusing on three possible mechanisms: inflammatory reaction, oral microorganisms and immune response. Specifically, elevated systemic inflammation and increased periodontal pathogens with their toxic products, along with a relatively suppressed immune system may lead to the disruption of homeostasis within fetal-placental unit and thus induce adverse pregnancy outcomes. This review also explains the possible mechanisms around why women are more susceptible to periodontal disease. In conclusion, pregnant women are more likely to develop periodontal disease due to hormonal changes, and periodontal disease has also been suspected to increase the incidence of adverse pregnancy outcomes. Therefore, in order to lessen the risk of adverse pregnancy outcomes, both obstetricians and dentists should pay attention to the development of periodontal diseases among women during pregnancy.

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Sex Steroid Hormones as a Balancing Factor in Oral Host Microbiome Interactions

Cited by 21 publications

References 103 publications

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

Prevotella species as oral residents and infectious agents with potential impact on systemic conditions

The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis

The bidirectional relationship between periodontal disease and pregnancy via the interaction of oral microorganisms, hormone and immune response

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