Sex steroid hormone receptors in bladder cancer: Usefulness in differential diagnosis and implications in histogenesis of bladder cancer

Imai, Yasuo; Noda, Shuhei; Matsuyama, Chiaki; Shimizu, Ayako; Kamai, Takao

doi:10.1016/j.urolonc.2019.01.023

Cited by 11 publications

(17 citation statements)

References 25 publications

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“…Additionally, it may explain why the differential diagnostic efficacy of the relative enhancement CT value in the arterial phase was superior to the other indicators in comprehensive consideration of the AUC, specificity, and sensitivity performance. Previous studies have also suggested that measurement of the expression of hormone receptors such as estrogen receptor alpha may assist in the diagnosis of primary bladder cancer [ 18 ]. However, such measurements are not in widespread use because of susceptibility to differences in experimental procedures and interobserver variability.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Enhanced Computed Tomography in Differentiating Cystitis Glandularis and Bladder Cancer

Hua

Gao

Lin

et al. 2020

BioMed Research International

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Objective. This study was performed to assess the value of quantitative analysis of enhanced computed tomography (CT) values in the differential diagnosis of bladder cancer and cystitis glandularis (CG). Methods. Eighty patients with bladder masses (39 with CG and 41 with bladder cancer) who underwent enhanced CT were retrospectively reviewed. The CT enhancement values of the lesion and normal bladder wall in the arterial phase, venous phase, and delayed phase were measured. The relative enhancement CT values (relative enhancement CT value=enhancement CT value of lesion−enhancement CT value of normal bladder) in the arterial phase, venous phase, and delayed phase were also calculated. The pathological results were used as the gold standard, and the area under the curve (AUC), sensitivity, and specificity were calculated for the six groups of quantitative indicators (enhanced CT values and relative enhanced CT values of CG and bladder cancer in the arterial, venous, and delayed phases). We performed the leave-group-out cross-validation method to validate the accuracy, AUC, sensitivity, and specificity. The differences in accuracy, AUC, sensitivity, and specificity among the six groups of quantitative indicators were compared by the t-test. Results. In a combined analysis of the AUC, sensitivity, and specificity performance, the best indicator was the arterial-phase relative enhancement CT value with a cut-off of 25.85 HU (AUC, 0.966; sensitivity, 95.1%; specificity, 92.3%). We used the 100-times leave-group-out cross-validation method to validate the accuracy, AUC, sensitivity, and specificity. Arterial-phase relative enhancement CT values showed the highest AUC and accuracy among the six groups, with statistical significance (P<0.05). Conclusion. Quantitative analysis of enhanced CT is of great clinical value in the differential diagnosis of CG and bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Enhanced Computed Tomography in Differentiating Cystitis Glandularis and Bladder Cancer

Hua

Gao

Lin

et al. 2020

BioMed Research International

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“…The positive rate of ERa expression in urothelial tumors ranged from 0% to 38% (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)36). ERa expression was shown to be significantly down-regulated in tumors, compared with non-tumors, in three studies (22,26,36), while the positivity was even lower, with no statistical significance, in non-tumors in other three studies (17,23,28).…”

Section: Expression Of Er In Surgical Specimensmentioning

confidence: 92%

“…Two studies (17,18) showed significant up-regulation of ERa expression in grade 3 tumors (vs. grade 1-2 tumors), whereas the down-regulation in high-grade tumors was reported in at least four of the other studies (no statistical significance in three of them) (16,22,26,36). Similarly, compared with lower stage tumors, both significant (16,18) or marginal (27) up-regulation and significant down-regulation (20,22) in higher stage tumors, such as muscle-invasive bladder cancer, were observed. However, there were no significant associations of ERa expression with patient outcomes (17,20,22,24,26,28,36).…”

Section: Expression Of Er In Surgical Specimensmentioning

confidence: 96%

The Role of Estrogen Receptors in Urothelial Cancer

Goto

Miyamoto

2021

Front. Endocrinol.

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Epidemiological data have indicated that there are some sex-related differences in bladder cancer. Indeed, the incidence of bladder cancer in men has been substantially higher than that in women throughout the world, while women tend to have higher stage disease and poorer prognosis. These gender disparities have prompted to investigate sex hormones and their cognitive receptors in bladder cancer. Specifically, estrogen receptors, including estrogen receptor-α and estrogen receptor-β, have been shown to contribute to urothelial carcinogenesis and cancer progression, as well as to modulating chemosensitivity in bladder cancer, although conflicting findings exist. Meanwhile, immunohistochemical studies in surgical specimens have assessed the expression of estrogen receptors and related proteins as well as its associations with clinicopathologic features of bladder cancer and patient outcomes. This review article summarizes and discusses available data indicating that estrogen receptor signaling plays an important role in urothelial cancer.

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“…The expression of ERα and ERβ has been immunohistochemically compared in bladder cancer specimens versus corresponding benign tissues ( Table 1). The rates of ERα positivity were shown to be significantly higher in non-neoplastic urothelium than in tumor [11], while other studies showed no significant differences in ERα expression between non-neoplastic and neoplastic tissues [12,22]. Our recent meta-analysis of immunohistochemical studies in bladder specimens also revealed a significant difference in ERα expression between non-tumor and tumor (p < 0.001) [15].…”

Section: Ersmentioning

confidence: 49%

“…Immunohistochemical studies showed the rates of PR positivity were <5% and 13-16% in bladder and UUT specimens, and their differences between non-neoplastic urothelium and urothelial tumor were not statistically significant [12,13,22] (Table 1). However, no functional studies of PR signals in urothelial cancer have been reported, except for recent analysis of microarray datasets showing that PR gene was differentially expressed in normal urothelial tissues versus urothelial carcinomas [56].…”

Section: Prmentioning

confidence: 99%

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

Ide

Miyamoto

2020

Cancers

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Preclinical and/or clinical evidence has indicated a potential role of steroid hormone-mediated signaling pathways in the development of various neoplastic diseases, while precise mechanisms for the functions of specific receptors remain poorly understood. Specifically, in urothelial cancer where sex-related differences particularly in its incidence are noted, activation of sex hormone receptors, such as androgen receptor and estrogen receptor-β, has been associated with the induction of tumor development. More recently, glucocorticoid receptor has been implied to function as a suppressor of urothelial tumorigenesis. This article summarizes and discusses available data suggesting that steroid hormone receptors, including androgen receptor, estrogen receptor-α, estrogen receptor-β, glucocorticoid receptor, progesterone receptor and vitamin D receptor, as well as their related signals, contribute to modulating urothelial tumorigenesis.

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Sex steroid hormone receptors in bladder cancer: Usefulness in differential diagnosis and implications in histogenesis of bladder cancer

Cited by 11 publications

References 25 publications

Quantitative Analysis of Enhanced Computed Tomography in Differentiating Cystitis Glandularis and Bladder Cancer

Quantitative Analysis of Enhanced Computed Tomography in Differentiating Cystitis Glandularis and Bladder Cancer

The Role of Estrogen Receptors in Urothelial Cancer

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

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