Sex-Specific Viability, Sex Linkage and Dominance in Genomic Imprinting

Cleve, Jeremy Van; Feldman, Marcus W.

doi:10.1534/genetics.107.071555

Cited by 23 publications

(22 citation statements)

References 50 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of dominance effects can favor or disfavor the evolution of genomic imprinting solely because monoallelic expression removes the opportunity for dominance effects to be expressed in heterozygotes (i.e., removes the physiological basis for dominance). As a result, imprinting can be favored solely because it leads to monoallelic expression, not because parent-of-origin-dependent expression is favored per se (47,48).…”

Section: Modelmentioning

confidence: 99%

Evolution of genomic imprinting as a coordinator of coadapted gene expression

Wolf

2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Genomic imprinting is an epigenetic phenomenon in which the expression of a gene copy inherited from the mother differs from that of the copy inherited from the father. Many imprinted genes appear to be highly interconnected through interactions mediated by proteins, RNA, and DNA. These kinds of interactions often favor the evolution of genetic coadaptation, where beneficially interacting alleles evolve to become coinherited. Here I demonstrate theoretically that the presence of gene interactions that favor coadaptation can also favor the evolution of genomic imprinting. Selection favors genomic imprinting because it coordinates the coexpression of positively interacting alleles at different loci. Evolution is expected to proceed through a scenario where selection builds associations between beneficial combinations of alleles and, if one locus evolves to become imprinted, it leads to selection for its interacting partners to match its pattern of imprinting. This process should favor the evolution of physical linkage between interacting genes and therefore may help explain why imprinted genes tend to be found in clusters. The model suggests that, whereas some genes are expected to evolve their imprinting status because selection directly favors a specific pattern of parent-of-origin-dependent expression, other genes may evolve imprinting as a coevolutionary response to match the expression pattern of their interacting partners. As a result, some genes will show phenotypic effects consistent with the predictions of models for the evolution of genomic imprinting (e.g., conflict models), but other genes may not, having simply evolved imprinting to follow the lead of their interacting partners.

show abstract

Section: Modelmentioning

confidence: 99%

Evolution of genomic imprinting as a coordinator of coadapted gene expression

Wolf

2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…We further study whether such an allele has the potential to reduce the rate of deleterious mutation accumulation and thus release the population from a fast fitness decline. The use of modifier alleles, such as modifiers of the recombination rate or of the mutation rate, has a long history in understanding the key evolutionary forces that explain genetic systems (Felsenstein 1974;Dawson 1999;Keightley and Otto 2006;Van Cleve and Feldman 2007). SIMULATION …”

Section: S Exual Reproduction Involves Exchange Of Geneticmentioning

confidence: 99%

Sex and Deleterious Mutations

Gordo

Campos

2008

Genetics

View full text Add to dashboard Cite

The evolutionary advantage of sexual reproduction has been considered as one of the most pressing questions in evolutionary biology. While a pluralistic view of the evolution of sex and recombination has been suggested by some, here we take a simpler view and try to quantify the conditions under which sex can evolve given a set of minimal assumptions. Since real populations are finite and also subject to recurrent deleterious mutations, this minimal model should apply generally to all populations. We show that the maximum advantage of recombination occurs for an intermediate value of the deleterious effect of mutations. Furthermore we show that the conditions under which the biggest advantage of sex is achieved are those that produce the fastest fitness decline in the corresponding asexual population and are therefore the conditions for which Muller's ratchet has the strongest effect. We also show that the selective advantage of a modifier of the recombination rate depends on its strength. The quantification of the range of selective effects that favors recombination then leads us to suggest that, if in stressful environments the effect of deleterious mutations is enhanced, a connection between sex and stress could be expected, as it is found in several species. S EXUAL reproduction involves exchange of geneticinformation between individuals of a given species. Why this should be advantageous remains a matter of debate (Barton and Charlesworth 1998;Agrawal 2006). The number of theories to explain the prevalence of sex in the natural world has been increasing over several decades and a pluralistic view of the evolution of sex has been suggested by some (West et al. 1999). From the population genetics perspective one of the major consequences of sex and recombination is that it can break down linkage disequilibrium created in natural populations by selection and/or genetic drift (Felsenstein 1974). Linkage disequilibrium has therefore been considered the key for understanding the maintenance of sexual reproduction. Here we take a simple view and try to quantify the minimal conditions under which sex can evolve. The minimal model we study here has been the target of recent studies (Keightley and Otto 2006) and here we explore it further. It is based on the hypothesis put forward by H. J. Muller that sexual populations are more efficient at eliminating deleterious mutations and that in asexual populations a ratchet mechanism can operate (Felsenstein 1974). Muller's ratchet is the accumulation of slightly deleterious mutations in an asexual population and its continuous genetic degeneration by the stochastic loss of its best-fit individuals. The relevant evolutionary forces in question when studying the ratchet are mutation, purifying selection, and random genetic drift. Muller's ratchet is a particular case of the more general HillRobertson effect, which states that selection at one locus affects the efficacy of selection at other linked loci (Hill and Robertson 1966;Felsenstein 1974;Comeron et al. 2008). Th...

show abstract

“…Burt and Trivers (1998) described conflict between imprinting genes and imprinted genes (also see Wilkins, 2005;Wolf and Wade, 2009). Van Cleve and Feldman (2007) distinguish cis-acting and trans-acting modifiers. The key theoretical distinction is whether an allele's effects discriminate among sibs on the basis of whether an offspring inherits the allele, not whether the allele is expressed in the parent or offspring generation.…”

Section: Introductionmentioning

confidence: 99%

Coadaptation and conflict, misconception and muddle, in the evolution of genomic imprinting

Haig

2013

Heredity

View full text Add to dashboard Cite

Common misconceptions of the 'parental conflict' theory of genomic imprinting are addressed. Contrary to widespread belief, the theory defines conditions for cooperation as well as conflict in mother-offspring relations. Moreover, conflict between genes of maternal and paternal origin is not the same as conflict between mothers and fathers. In theory, imprinting can evolve either because genes of maternal and paternal origin have divergent interests or because offspring benefit from a phenotypic match, or mismatch, to one or other parent. The latter class of models usually require maintenance of polymorphism at imprinted loci for the maintenance of imprinted expression. The conflict hypothesis does not require maintenance of polymorphism and is therefore a more plausible explanation of evolutionarily conserved imprinting.

show abstract

Sex-Specific Viability, Sex Linkage and Dominance in Genomic Imprinting

Cited by 23 publications

References 50 publications

Evolution of genomic imprinting as a coordinator of coadapted gene expression

Evolution of genomic imprinting as a coordinator of coadapted gene expression

Sex and Deleterious Mutations

Coadaptation and conflict, misconception and muddle, in the evolution of genomic imprinting

Contact Info

Product

Resources

About