Sex-specific role of galectin-3 in aortic stenosis
Lara Matilla,
Ernesto Martín-Núñez,
Mattie Garaikoetxea
et al.
Abstract:Background
Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop these mechanisms differently. Galectin-3 (Gal-3) is a pro-inflammatory and pro-osteogenic lectin in AS. In this work, we aim to analyse a potential sex-differential role of Gal-3 in AS.
Methods
226 patients (61.50% men) with severe AS undergoing surgical aortic valve (AV) replacement were recruited. In AVs, Gal-3 expressi… Show more
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