Sex-Specific Orientation in Female and Male Rats: Development and Effects of Early Endocrine Manipulation

Meyerson, Bengt J.; Eliasson, Mona; Hetta, Jerker

doi:10.1016/b978-0-08-024940-7.50032-9

Cited by 23 publications

(13 citation statements)

References 3 publications

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“…As mentioned already, numerous experiments (Bakker et al, 1993;Baum et al, 1990;de Jonge et al, 1988;Johnson and Tiefer, 1972;Meyerson et al, 1978) have explored the contribution of organizational actions of testosterone and/or of estradiol to the differentiation of circuits that control sex partner preference and mate recognition in the male. An alternative explanation of hardwired sex differences in brain circuits that control social behavior, including the processing of pheromones, involves direct neural actions of genes expressed off either the X and/or Y chromosome during development (McCarthy and Arnold, 2011).…”

Section: Role Of Sex Chromosome Genes In Odor Preferencesmentioning

confidence: 99%

Roles of sex and gonadal steroids in mammalian pheromonal communication

Baum

Bakker

2013

Frontiers in Neuroendocrinology

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a b s t r a c t A brain circuit (the accessory olfactory system) that originates in the vomeronasal organ (VNO) and includes the accessory olfactory bulb (AOB) plus additional forebrain regions mediates many of the effects of pheromones, typically comprised of a variety of non-volatile and volatile compounds, on aspects of social behavior. A second, parallel circuit (the main olfactory system) that originates in the main olfactory epithelium (MOE) and includes the main olfactory bulb (MOB) has also been shown to detect volatile pheromones from conspecifics. Studies are reviewed that point to specific roles of several different steroids and their water-soluble metabolites as putative pheromones. Other studies are reviewed that establish an adult, 'activational' role of circulating sex hormones along with sex differences in the detection and/or processing of non-steroidal pheromones by these two olfactory circuits. Persisting questions about the role of sex steroids in pheromonal processing are posed for future investigation.

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Section: Role Of Sex Chromosome Genes In Odor Preferencesmentioning

confidence: 99%

Roles of sex and gonadal steroids in mammalian pheromonal communication

Baum

Bakker

2013

Frontiers in Neuroendocrinology

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“…Thus, even the ovary may be active (Do Èhler & Wuttke, 1975), the absence of gonadal steroid hormones reaching the central nervous system during early development, produce typical female characteristics (Beach, 1976). Conversely, the administration of aromatizable androgens (Luttge & Whalen, 1970) to immature females completely alters their reproductive physiology: females showed no ovarian nor gonadotropin cyclicity with delayed or absent vaginal opening (Swanson & van der Werff ten Bosch, 1964), suppression of lordotic behavior accompanied by a higher incidence of mounting (male sexual behavior) (DeJonge, Muntjewerff, Louwerse, & van de Poll, 1988), a behavioral repertoire similar to that of male subjects (Meyerson, Eliasson, & Hetta, 1980), brain anatomy with male characteristics (Handa, Corbier, Shryne, Schoonmaker, & Gorski, 1985) with larger granule cell layer (Roof & Havens, 1992), and size of CA1 and CA3 pyramidal cells (Isgor & Sengelaub, 1998) and higher GABA levels (Davis, Ward, Selmanoff, Herbison, & McCarthy, 1999). Importantly, also a virilized EEG, characterized by higher theta RP and lower delta and beta RP, may be produced in females prenatally treated with androgens (Jua Ârez et al, 1995).…”

mentioning

confidence: 99%

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

et al. 2000

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mentioning

confidence: 99%

“…Thus, examination of a female rat exposed to a sexually active male can easily assess her sexual receptivity. Sexual motivation is somewhat more difficult to investigate; however, tentatively, this aspect of sexual behavior may be reflected by the time spent by a female rat in the vicinity of a male rather than a female, or elsewhere (Meyerson et al 1978;Vega Matuszczyk and Larsson 1993).In the present study, the extent to which the sexual side effects induced by SRIs in women can be mirrored in animal experiments was addressed; to this end, we investigated the effect of subchronic administration of the selective SRI fluoxetine (Fuller et al 1991) on various aspects of female sexual behavior. In the first experiment, the effects of 1 to 3 weeks of fluoxetine administration on sexual receptivity in the estrous phase of normally cycling animals was studied.…”

mentioning

confidence: 99%

Subchronic Administration of Fluoxetine Impairs Estrous Behavior in Intact Female Rats

Matuszczyk

Larsson

Eriksson

1998

Neuropsychopharmacology

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Treatment with serotonin reuptake inhibitors (SRIs) has been shown to cause reduced libido and anorgasmia in women.A large body of evidence suggests that serotonin may influence sexual behavior in estradiol ϩ progesterone primed, gonadectomized female rats; however, the influence of selective SRIs on the estrous behavior of intact female rats has not been described previously. In the present study, the effect of 1 to 3 weeks of fluoxetine administration (10 mg/kg daily) on vaginal and behavioral estrus in intact female rats was studied; in addition, the effect of fluoxetine (same dose, 1-8 Treatment with serotonin reuptake inhibitors (SRIs) has been reported to reduce libido in both sexes, to cause anorgasmia in women (Monteiro et al. 1987;Herman et al. 1990;Zajecka et al. 1991;Balon 1995;Eriksson et al. 1995;Shen and Hsu 1995;Feiger et al. 1996;Sundblad et al. 1997) and to increase ejaculation latency in men (Hsu and Chen 1995;Waldinger et al. 1994;Kara et al. 1996). Particularly when the SRIs are used for prophylactic purposes in patients that have recovered from depression, and when they are used for psychiatric conditions not associated with a reduction in libido (such as panic disorder, obsessive compulsive disorder, and premenstrual dysphoria) (Eriksson and Humble 1990), sexual dysfunction is probably the most cumbersome of the SRI-associated side effects.Given the fact that all serotonin reuptake inhibitors, despite marked differences in chemical structure, induce similar sexual side effects, it is likely that these effects are, indeed, attributable to inhibition of the serotonin transporter and to a subsequent increase in the synaptic concentrations of serotonin. However, the postsynaptic receptor subtype(s) mediating the effects of serotonin reuptake inhibitors on sexual behavior and the brain region in which these effects are exerted have yet to be clarified. Also, to what extent the reduction in libido and difficulty in achieving orgasm are causally related remains to be established.Needless to say, the elucidation of the mechanisms underlying SRI-induced sexual side effects would be facilitated if these effects could be studied in animal ex- NO . 6 Fluoxetine Impairs Estrous Behavior 493 periments. Previous studies by us and others have shown that administration of an SRI to male rats does induce changes in sexual behavior similar to those observed in humans (Ahlenius et al. 1979;Yells et al. 1994; Yells et al. 1995;Taylor et al. 1996; Vega Matuszczyk et al. 1988); in contrast, there are, to our knowledge, no studies on the effect of subchronic administration of a selective SRI on sexual behavior in female rats.Intact female rats in the estrous phase-as well as gonadectomized females primed with estradiol and progesterone-respond to male mounting with a characteristic dorsiflexion of the back that can be easily registered, socalled lordosis behavior. In addition, the female solicits male sexual activity by distinct presenting postures, such as darting, hopping, and ear wiggling (Beach 1976)...

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Sex-Specific Orientation in Female and Male Rats: Development and Effects of Early Endocrine Manipulation

Cited by 23 publications

References 3 publications

Roles of sex and gonadal steroids in mammalian pheromonal communication

Roles of sex and gonadal steroids in mammalian pheromonal communication

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Subchronic Administration of Fluoxetine Impairs Estrous Behavior in Intact Female Rats

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