2020
DOI: 10.1007/s11357-020-00163-7
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Abstract: Physical frailty and cognitive frailty share biological mechanisms, but sex-specific biomarkers associated with transitions in gait speed and cognition during ageing are poorly understood.Gait speed, cognition (3MSE), body composition (DXA) and serological biomarkers were assessed annually over 9 years in 216 males (72.7 + 8.07 years) and 384 females (71.1 + 8.44 years). In females, maintaining normal gait speed was associated with lower percent body fat (IRR 0.793, p = 0.001, 95%CI 0.691-0.910) and lower lact… Show more

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Cited by 12 publications
(7 citation statements)
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References 32 publications
(31 reference statements)
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“…Sex‐based subgroups analysis revealed borderline significant improvement in maximal gait speed among men. Reasons for the difference in training response may lie in sex‐specific muscle and metabolic biomarkers that are associated with gait speed and cognition 38 . Even though the subgroup analyses of this study were preplanned, the number of participants in these analyses do not allow us to draw definite conclusions.…”
Section: Discussionmentioning
confidence: 89%
“…LDH levels have previously been highlighted as markers for the severity of COVID-19 ( Henry et al, 2020 ). The maintenance of normal cognition in older adults is highly correlated with low levels of LDH ( Waters et al, 2020 ). No correlation was found between oxygen saturation and cognitive dysfunction, suggesting that the deficits were not caused by brain hypoxia.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, high LDL levels were associated with lower risk of cognitive impairment in the oldest elderly (aged 80 and older), but not in the [53,55]. Improved cognition was associated with lower triglyceride only in males [56]. However, a recent study showed that high total serum cholesterol in later life compared to midlife was not associated with any form of dementia or cognitive decline [45].…”
Section: Disputes: Can Statin Lipid-lowering Erapy Affect Cognitive Imentioning
confidence: 98%
“…More recently, sarcopenia in men was found to be associated with high cholesterol and lower creatinine levels. Conversely, in women, the maintenance of normal gait speed was found to be associated with a lower percentage of body fat and lower lactate dehydrogenase levels [15].…”
Section: Introductionmentioning
confidence: 94%
“…In this context, we would like to understand if there is a relationship between circulating biomarkers and loss of muscle mass and function or if other mechanisms contribute to longevity. Furthermore, it has been recently demonstrated that biomarkers of successful aging are sex-related [14,15], and thus gender has to be considered. In a previous study conducted in male aged subjects, the loss of muscle function was connected to the loss of phosphorylatable myosin light chain, which regulates the velocity of fiber contraction, and of changes in muscle metabolism, resulting in fat accumulation [16,17].…”
Section: Introductionmentioning
confidence: 99%