Sex-specific molecular genetic response to UVB exposure in Xiphophorus maculatus skin

Boswell, William T.; Boswell, Mikki; Titus, James K; Savage, Markita; Lu, Yuan; Shen, Jianjun; Walter, Ronald B.

doi:10.1016/j.cbpc.2015.07.007

Cited by 15 publications

(22 citation statements)

References 73 publications

(78 reference statements)

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“…The female vs. male melanoma incidence for UVB-exposed Xiphophorus is consistent with that seen in the human population, suggesting a sex-specific molecular genetic response [7]. Another study performed on Xiphophorus maculatus showed differences in the genetic perception of UVB in males and females, consistent with a twofold higher incidence of melanoma in males vs. females [11].…”

Section: The Sex Bias Of Melanomasupporting

confidence: 75%

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

2020

Rev.Chim.

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Differences across sexes in cutaneous melanoma incidence, metastatic pathways and disease outcome are consistently observed, with women having a significant survival advantage compared with men. This suggests that gender could play a role as a prognostic indicator through sex hormone signaling, but the mechanism is still unclear. This article focuses on available literature data concerning the influence of estrogen receptor beta (ERβ) expression as a host-related biological protective factor for female patients with melanoma. Furthermore, it highlights the potential role of estrogen receptor beta (ERβ) as a prognostic biologic marker in cutaneous melanoma. Keywords: melanoma, sex, hormone receptors, estrogen receptor β

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Section: The Sex Bias Of Melanomasupporting

confidence: 75%

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

2020

Rev.Chim.

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“…Moreover, a significant disparity has also been noted in the prognosis of this tumor between males and females, with women having a significant survival advantage over men (62–64). Finally, studies performed in a melanoma fish model ( Xiphophorus couchianus ) showed a twofold lower incidence of melanoma in females than in males after acute exposure to UVB irradiation, and this was accompanied by a sex-specific molecular genetic response (65). …”

Section: The Sex Hormone Milieu and Melanomamentioning

confidence: 99%

Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility

et al. 2016

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Cutaneous melanoma is an aggressive tumor; its incidence has been reported to increase fast in the past decades. Melanoma is a heterogeneous tumor, with most patients harboring mutations in the BRAF or NRAS oncogenes, leading to the overactivation of the MAPK/ERK and PI3K/Akt pathways. The current therapeutic approaches are based on therapies targeting mutated BRAF and the downstream pathway, and on monoclonal antibodies against the immune checkpoint blockade. However, treatment resistance and side effects are common events of these therapeutic strategies. Increasing evidence supports that melanoma is a hormone-related cancer. Melanoma incidence is higher in males than in females, and females have a significant survival advantage over men. Estrogens exert their effects through estrogen receptors (ERα and ERβ) that affect cancer growth in an opposite way: ERα is associated with a proliferative action and ERβ with an anticancer effect. ERβ is the predominant ER in melanoma, and its expression decreases in melanoma progression, supporting its role as a tumor suppressor. Thus, ERβ is now considered as an effective molecular target for melanoma treatment. 17β-estradiol was reported to inhibit melanoma cells proliferation; however, clinical trials did not provide the expected survival benefits. In vitro studies demonstrate that ERβ ligands inhibit the proliferation of melanoma cells harboring the NRAS (but not the BRAF) mutation, suggesting that ERβ activation might impair melanoma development through the inhibition of the PI3K/Akt pathway. These data suggest that ERβ agonists might be considered as an effective treatment strategy, in combination with MAPK inhibitors, for NRAS mutant melanomas. In an era of personalized medicine, pretreatment evaluation of the expression of ER isoforms together with the concurrent oncogenic mutations should be considered before selecting the most appropriate therapeutic intervention. Natural compounds that specifically bind to ERβ have been identified. These phytoestrogens decrease the proliferation of melanoma cells. Importantly, these effects are unrelated to the oncogenic mutations of melanomas, suggesting that, in addition to their ERβ activating function, these compounds might impair melanoma development through additional mechanisms. A better identification of the role of ERβ in melanoma development will help increase the therapeutic options for this aggressive pathology.

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“…metabolism, cytoskeletal, and detoxification) have been documented in mammalian systems (Albrecht et al, 1997; Akhtar et al, 2002). In addition, recent studies have shown gene expression in fish skin to be light responsive (Walter et al, 2014; Boswell et al, 2015, Walter et al, 2015). However, these previous reports dealt exclusively with ultraviolet wavelengths, or more recently, with broad-spectrum fluorescent lights.…”

Section: Discussionmentioning

confidence: 99%

“…Although the global genetic effects of UV and fluorescent lights have been studied (Yang et al, 2014; Boswell et al, 2015; Lu et al, 2015; Walter et al, 2015), these studies employed broad spectrum light sources. With the increasing prevalent use of broad spectrum artificial lighting, these reports collectively began the elucidation of the role light may play in altering global gene expression profiles.…”

Section: Discussionmentioning

confidence: 99%

Molecular genetic response to varied wavelengths of light in Xiphophorus maculatus skin

Chang¹,

Lu²,

Boswell³

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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Xiphophorus fishes represent a model often utilized to study UVB induced tumorigenesis. Recently, varied genetic responses to UVB exposure has been documented in the skin of female and male Xiphophorus, as have differences in UVB response in the skin of different parental species and for interspecies hybrids produced from crossing them. Additionally, it has been shown that exposure to “cool white” fluorescent light induces a shift in the genetic profiles of Xiphophorus skin that is nearly as robust as the UVB response, but involves a fundamentally different set of genes. Given these results and the use of Xiphophorus interspecies hybrids as an experimental model for UVB inducible melanoma, it is of interest to characterize genes that may be transcriptionally modulated in a wavelength specific manner. The global molecular genetic response of skin upon exposure of the intact animal to specific wavelengths of light has not been investigated. Herein, we report results of RNA-Seq experiments from the skin of male Xiphophorus maculatus Jp 163 B following exposure to varied 50 nm wavelengths of light ranging from 300–600 nm. We identify two specific wavelength regions, 350–400 nm (88 genes) and 500–550 nm (276 genes) that exhibit transcriptional modulation of a significantly greater number of transcripts than any of the other 50 nm regions in the 300–600 nm range. Observed functional sets of genes modulated within these two transcriptionally active light regions suggest different mechanisms of gene modulation.

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Sex-specific molecular genetic response to UVB exposure in Xiphophorus maculatus skin

Cited by 15 publications

References 73 publications

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

The Evaluation of Estrogen Receptor β as a Potential Prognosis Factor in Melanoma

Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility

Molecular genetic response to varied wavelengths of light in Xiphophorus maculatus skin

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