Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients

Gjerde, Priyanthi Borgen; Simonsen, Carmen; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole A.; Steen, Vidar M.; Melle, Ingrid

doi:10.3389/fpsyt.2021.723158

Cited by 4 publications

(4 citation statements)

References 83 publications

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“…In short, such findings may help explain our results, which found that the effect of TG on ECN‐related inter‐network FC was sex‐dependent. Our results, together with those of previous studies (Gjerde et al., 2021 ; Seyfried et al., 2018 ; Xu et al., 2021 ; Yin et al., 2018 ), suggest that alterations in inter‐network FC may be a potential network mechanism of lipid‐involved neuropsychiatric disorders that exhibit sex dimorphism.…”

Section: Discussionsupporting

confidence: 85%

“…Our results, together with those of previous studies (Gjerde et al, 2021;Seyfried et al, 2018;Xu et al, 2021;Yin et al, 2018), suggest that alterations in inter-network FC may be a potential network mechanism of lipid-involved neuropsychiatric disorders that exhibit sex dimorphism.…”

Section: Discussionsupporting

confidence: 83%

“…Thus, our findings suggest that sex may be an important factor that needs to be considered when examining the relationship between serum lipid levels, brain, and cognition. Extensive studies have revealed that serum lipids, as well as sex dimorphism, are involved in the onset and progression of different neuropsychiatric disorders, such as depression (Xu et al, 2021), first-episode schizophrenia (Gjerde et al, 2021), cerebral small vessel disease (Yin et al, 2018), and Parkinson's disease (Seyfried et al, 2018). However, the neurobiological bases of the sex-specific different contributions of lipids fractions on neuropsychiatric disorders are still unclear, probably due to the few studies available to date which have carried out sex-stratified analysis.…”

Section: Discussionmentioning

confidence: 99%

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Impact of sex and serum lipids interaction on working memory: A large‐scale brain networks study

Zhang

Sun

et al. 2023

Brain and Behavior

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Backgrounds: Previous studies have demonstrated that both serum lipid levels and sex are crucial factors associated with individual cognition. However, the impact of sex and serum lipid interaction effects on the brain and cognition remains largely unknown.This study aimed to explore the underlying neural mechanisms among sex, serum lipids, and cognition using large-scale brain networks. Methods:Resting-state functional MRI data were collected from 157 young healthy adults. Independent component analysis was used to examine large-scale inter-and intra-network functional connectivity (FCs). Peripheral venous blood samples were collected to measure serum lipid levels. The three-back task was employed to assess cognition (i.e., working memory). General linear model, correlation, and mediation analyses were conducted to examine the interaction effects of sex and serum lipids on large-scale brain networks and their relationship with working memory. Results:We found that inter-network connectivity with the executive control network at its core was more susceptible to sex and triglyceride interaction effects. The intra-network connectivity in the dorsal attention networks (DANs), lateral visual networks, and anterior default mode networks was influenced by the interaction effects of sex and total cholesterol (TC)/low-density lipoprotein cholesterol. Specifically, correlations between serum lipids and affected brain networks were found to be sex-specific.In addition, higher intra-network FC in the right inferior parietal (R-IPL) of the DAN correlated with a longer three-back reaction time in females. More importantly, the relationship between serum TC levels and three-back reaction time was mediated by intra-network connectivity in the R-IPL of the DAN.Conclusions: Our findings describe the impact of sex and serum lipid interaction effects on large-scale brain networks, as well as on cognitive function. Our data suggest that sex-specific usage of serum lipids or brain networks would be beneficial for monitoring and therapy in dyslipidemia-related cognition decline.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Impact of sex and serum lipids interaction on working memory: A large‐scale brain networks study

Zhang

Sun

et al. 2023

Brain and Behavior

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“…In recent years, there have been numerous studies examining the relationship between MDD patients and biochemical markers, aiming to explore measurable indicators for MDD patients [16][17][18]. Additionally, there is substantial evidence indicating a connection between hormone levels [19][20][21]and metabolic markers [22,23] to PS in MDD patients. To illustrate, Contreras et al discovered that approximately 80% of depression samples exhibited at least one hormonal axis disturbance, with 40.0% and 5.0% experiencing two and three hormone axis disturbances, respectively [19].…”

Section: Introductionmentioning

confidence: 99%

Predictors of psychotic symptoms in first-episode and drug-naïve major depressive disorder patients with a history of suicide attempts: A large cross-sectional study

Yang,

Wang,

Feng

et al. 2024

Preprint

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Background: Psychotic symptoms (PS) are common in patients with major depressive disorder (MDD); however, few studies have examined risk factors for PS in first-episode and drug-naïve (FEDN) MDD patients with a history of suicide attempts. The purpose of this study was to investigate the incidence and risk factors for PS in FEDN MDD patients with a history of suicide attempts, with the aim of providing implications for early intervention. Methods: A total of 1718 FEDN MDD patients were recruited through a cross-sectional study. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess patients’ symptoms. In addition, demographic data and clinical indicators were collected. Results: We found that FEDN MDD patients with a history of suicide attempts were 5.06 times more likely to have PS than those without a history of suicide attempts. HAMD score, HAMA score, and thyroid-stimulating hormone (TSH) were significant predictors of PS in FEDN MDD patients with a history of suicide attempts. The combined area under the curve (AUC) value of 0.94 distinguished patients with PS from those without PS. Conclusions: This study shows a high prevalence of PS in FEDN MDD patients with a history of suicide attempts. Anxiety symptoms, depressive symptoms, and TSH levels appear to predict PS in FEDN MDD patients with a history of suicide attempts.

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Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders

Luckhoff,

Suliman,

van den Heuvel

et al. 2024

Psychiatry Research Communications

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Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients

Cited by 4 publications

References 83 publications

Impact of sex and serum lipids interaction on working memory: A large‐scale brain networks study

Impact of sex and serum lipids interaction on working memory: A large‐scale brain networks study

Predictors of psychotic symptoms in first-episode and drug-naïve major depressive disorder patients with a history of suicide attempts: A large cross-sectional study

Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders

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