Sex-specific associations of maternal birthweight with offspring birthweight in the Omega study

Ncube, Collette N.; Gavin, Amelia R.; Williams, Michelle A.; Qiu, Chunfang; Sorensen, Tanya K.; Enquobahrie, Daniel A.

doi:10.1016/j.annepidem.2017.04.006

Cited by 5 publications

(3 citation statements)

References 53 publications

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“…Our results are in good agreement with those of a previous study reporting associations of maternal birthweight with offspring birthweight among mothers who themselves had a normal birthweight or macrosomia. 33 Like our findings, the associations differed depending on offspring sex. Our results also demonstrated an association between early pregnancy BMI and offspring birthweight, which has been reported by other investigators.…”

Section: Discussionsupporting

confidence: 71%

Relation of maternal birthweight with early pregnancy obesity, gestational diabetes, and offspring macrosomia

Johnsson

Lindberger

Ahlsson

et al. 2022

J Dev Orig Health Dis

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This study aimed to investigate how maternal birthweight is related to early pregnancy obesity, gestational diabetes mellitus (GDM), and offspring birthweight. Females born term and singleton in Sweden between 1973 and 1995 (N = 305,893) were studied at their first pregnancy. Information regarding their birthweight, early pregnancy body mass index, and pregnancy complications was retrieved from the Swedish Medical Birth Register, as were data on their mothers and offspring. High maternal birthweights (2–3 standard deviation scores (SDS) and >3 SDS) were associated with greater odds of early pregnancy obesity, odds ratio (OR) 1.52 (95% confidence interval (CI) 1.42–1.63) and OR 2.06 (CI 1.71–2.49), respectively. A low maternal birthweight (<2 SDS) was associated with greater odds of GDM (OR 2.49, CI 2.00–3.12). No association was found between high maternal birthweight and GDM. A maternal birthweight 2–3 SDS was associated with offspring birthweight 2–3 SDS (OR 3.83, CI 3.44–4.26), and >3 SDS (OR 3.55, CI 2.54–4.97). Corresponding ORs for a maternal birthweight >3 SDS were 5.38 (CI 4.12–7.01) and 6.98 (CI 3.57–13.65), respectively. In conclusion, a high maternal birthweight was positively associated with early pregnancy obesity and offspring macrosomia. A low, but not a high maternal birthweight, was associated with GDM.

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Section: Discussionsupporting

confidence: 71%

Relation of maternal birthweight with early pregnancy obesity, gestational diabetes, and offspring macrosomia

Johnsson

Lindberger

Ahlsson

et al. 2022

J Dev Orig Health Dis

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“…Evaluating the sex-specific associations is important because previous studies have indicated that male and female offspring respond differently to adverse environmental exposures 55 , 56 . Moreover, trans-generational transmission of low birthweight linking maternal birthweight to offspring birthweight has been found to be sex-specific 57 . It should be noted that variations in the relative contribution of genetic and environmental factors on fetal growth may be due to the influence of different genetic loci at different stages of fetal growth, different levels of influence from the same locus at different gestational ages, and a combination of the two effects as well as gene-environment interactions.…”

Section: Discussionmentioning

confidence: 99%

Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy

Workalemahu

Grantz

Grewal

et al. 2018

Sci Rep

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Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC = 53%, HL = 57%, FL = 72%, EFW = 71%; p < 0.05). In contrast, shared environment explained most of phenotypic variations in fetal growth in the first trimester (AC = 50%, HL = 54%, FL = 47%, EFW = 54%; p < 0.05), suggesting that the first trimester presents an intervention opportunity for a more optimal early fetal growth. Genetic correlations between growth traits (range 0.34–1.00; p < 0.05) were strongest at the end of first trimester and declined with gestation, suggesting that different fetal growth measures are more likely to be influenced by the same genes in early pregnancy.

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“…Excessive weight gain, increased substance use, and severe headaches are other problems of AD for pregnant women (31). For the offspring, AD can not only lead to preterm birth or low birth weight, but also has a persistent adverse effect on their neurological, behavioral, and emotional development (30,32,33).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antenatal Maternal Mental Representations Between Depressed and Non-depressed Pregnant Mothers

Amini

Shakiba

Afrakhteh

et al. 2022

Iran J Psychiatry Behav Sci

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Background: Depression is the most prevalent mental health problem in the pregnant women with significant implications for mother and infant’s health. The content of maternal antenatal representations may be related to their depressive symptoms during the perinatal period. Objectives: This study aimed to compare maternal mental representations between depressed and non-depressed groups of pregnant women. Methods: In a causal-comparative study, participants were selected using an inverse stratified sampling method among pregnant women in the last trimester of pregnancy (depressed mothers = 93, and non-depressed mothers = 97). All participants completed Edinburgh Postnatal Depression Scale (EPDS), Dépistage Anténatal de la Dépression Postnatale (DADP), and semi-structure Interview-R after the consent form. Independent- samples t-test, Two-way ANOVA, and Pearson correlation coefficient were applied to compare maternal mental representations subscales between groups, using SPSS-26. Results: The results showed significantly fewer positive ratings for all subscales of Interview-R, including child, partner, self as mother, and mother as own mother in the depressed group (P < 0.05). In the group of depressed mothers, 57% and 32% of the correlations among the representations of child/self as mother and child/partner were significant, while in the non-depressed group, 28% and 48% of the correlations between child/self as mother and child/ partner were significant (P < 0,05), respectively. The characteristics of self as mother and own mother showed significant differences in the depressed group compared to the non-depressed group (P < 0.05). Conclusions: Depressed pregnant mothers are less likely to differentiate themselves from their children compared to non-depressed pregnant mothers. Besids, depressed pregnant mothers perceive themselves as mothers more positively than their own mothers, while the opposite is true for non-depressed pregnant mothers.

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Sex-specific associations of maternal birthweight with offspring birthweight in the Omega study

Cited by 5 publications

References 53 publications

Relation of maternal birthweight with early pregnancy obesity, gestational diabetes, and offspring macrosomia

Relation of maternal birthweight with early pregnancy obesity, gestational diabetes, and offspring macrosomia

Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy

Comparison of Antenatal Maternal Mental Representations Between Depressed and Non-depressed Pregnant Mothers

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