Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort

Jo, Heejoo; Eckel, Sandrah P.; Wang, Xinhui; Chen, Jiu Chiuan; Cockburn, Myles; Martinez, Mayra P.; Chow, Ting; Molshatzki, Noa; Lurmann, Frederick; Funk, William E.; Xiang, Anny H.; McConnell, Rob

doi:10.1016/j.envpol.2019.113010

Cited by 42 publications

(52 citation statements)

References 35 publications

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“…The review found evidence for associations between prenatal exposure to PM 2:5 and ASD (Lam et al 2016). Additional studies have been published since this review that have found positive associations between prenatal and/or early life PM 2:5 exposure and ASD (Kaufman et al 2019;Jo et al 2019;McGuinn et al 2020).…”

Section: Discussionmentioning

confidence: 80%

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Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Perera

Cooley

Berberian

et al. 2020

Environ Health Perspect

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BACKGROUND: While various policies have been implemented globally to mitigate climate change and reduce exposure to toxic air pollutants, policy assessments have considered few if any of the benefits to children. OBJECTIVE: To comprehensively assess the co-benefits of climate change mitigation to children, we expanded the suite of adverse health outcomes in the U.S. Environmental Protection Agency's Benefits Mapping and Analysis Program (BenMAP) to include additional outcomes associated with prenatal and childhood exposure to ambient fine particulate matter (PM 2:5). We applied this newly expanded program to an assessment of the U.S. Regional Greenhouse Gas Initiative (RGGI), the United States' first regional market-based regulatory program designed to reduce greenhouse gas emissions from the electric power sector within the Northeast. METHODS: We used calculated changes in ambient PM 2:5 concentrations for the period 2009-2014, with newly incorporated concentration-response (C-R) functions to quantify changes in the incidence of preterm birth (PTB), term low birth weight (TLBW), autism spectrum disorder (ASD), and asthma. These outcomes are causally or likely to be causally related to PM 2:5 exposure. Cost per case estimates were incorporated to monetize those changes in incidence. RESULTS: The estimated avoided cases of adverse child health outcomes included 537 asthma cases, 112 preterm births, 98 cases of ASD, and 56 cases of TLBW, with an associated avoided cost estimate ranging from $191 to $350 million. In a previous analysis of health benefits of RGGI, the only benefits accruing to children were limited to prevented cases of infant mortality and respiratory illnesses, with a monetized impact of $8.1 million-only 2-4% of the new results attributable to RGGI. CONCLUSION: The results of this innovative analysis indicate that RGGI has provided substantial child health benefits beyond those initially considered. Moreover, those health benefits had significant estimated economic value.

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Section: Discussionmentioning

confidence: 80%

“…Additional studies have been published since this review that have found positive associations between prenatal and/or early life

exposure and ASD ( Kaufman et al. 2019 ; Jo et al. 2019 ; McGuinn et al.…”

Section: Discussionmentioning

confidence: 99%

Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Perera

Cooley

Berberian

et al. 2020

Environ Health Perspect

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“…Although this is not confirmed by all the gathered evidences [64,67], the majority of the studies are largely consistent in reporting an association also after taking into account possible confounders [54]. A sex-specific interaction has also been suggested, with boys being more susceptible than girls [65,66].…”

Section: Air Pollutionmentioning

confidence: 91%

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

2020

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The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic regulation and synaptic function, have been identified to be either causative or risk factors of autism. On the other hand, exposure to chemicals that are widespread in the environment, such as endocrine disruptors, has been associated with adverse effects on human health, including neurodevelopmental disorders. Interestingly, experimental results suggest an overlap in the regulatory pathways perturbed by genetic mutations and environmental factors, depicting convergences and complex interplays between genetic susceptibility and toxic insults. The pervasive nature of chemical exposure poses pivotal challenges for neurotoxicological studies, regulatory agencies, and policy makers. This highlights an emerging need of developing new integrative models, including biomonitoring, epidemiology, experimental, and computational tools, able to capture real-life scenarios encompassing the interaction between chronic exposure to mixture of substances and individuals’ genetic backgrounds. In this review, we address the intertwined roles of genetic lesions and environmental insults. Specifically, we outline the transformative potential of stem cell models, coupled with omics analytical approaches at increasingly single cell resolution, as converging tools to experimentally dissect the pathogenic mechanisms underlying neurodevelopmental disorders, as well as to improve developmental neurotoxicology risk assessment.

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“…The presence of multiple methylated CpG sites in CpG islands of promoters often causes stable silencing of genes, 71 although this gene silencing can also be initiated by other mechanisms. 71 The placental also serves as a sensor and transducer of environmental signals, such as prenatal exposure to tobacco, [72][73][74][75] air pollution, [76][77][78][79][80][81][82][83][84][85][86][87][88][89][90] and environmental pollutants, [91][92][93][94] which have been tied to both neonatal morbidities and perinatal inflammation. Important questions remain in relation to the role of specific biological pathways in the placenta that when perturbed can lead to child health or disease.…”

Section: Mechanism 2: Disrupted Placental Programming and Neurodevelomentioning

confidence: 99%

Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm

et al. 2020

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Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort

Cited by 42 publications

References 35 publications

Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Co-Benefits to Children’s Health of the U.S. Regional Greenhouse Gas Initiative

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm

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