Sex-specific associations in verbal memory brain circuitry in early psychosis

Buck, Gabriella; Makowski, Carolina; Chakravarty, M. Mallar; Mišić, Bratislav; Joober, Ridha; Malla, Ashok; Lepage, Martín; Lavigne, Katie M.

doi:10.1016/j.jpsychires.2022.05.006

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…Interestingly, among patients, these differences in structural covariance-derived connectivity were significantly predictive of sex differences in verbal memory performance. Furthermore, Buck and colleagues (Buck et al 2022) observed that the poorer verbal memory demonstrated by male first-episode psychosis patients was associated with sex-dependent circuitry alterations. Future studies, such as those using patient data from the UKBB, can further investigate the way these sex differences may be moderated in clinical populations.…”

Section: Discussionmentioning

confidence: 99%

Normative Sex Differences in Cognition and Morphometric Brain Connectivity: Evidence from 30,000+ UK Biobank Participants

Yang

Totzek

Lepage

et al. 2022

Preprint

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There is robust evidence for sex differences in domain-specific cognitive performance in the general population, where females typically show an advantage for verbal memory (VM), while males tend to perform better on tasks of spatial memory (SM). Sex differences in brain structure and connectivity are also well-documented and may provide insight into sex differences in cognition. In this study, we examined sex differences in cognition and morphometric brain connectivity of a large healthy sample (N = 31,180) from the UK Biobank dataset. Using T1-weighted magnetic resonance imaging (MRI) scans and regional cortical thickness values, we applied jackknife bias estimation and graph theory to obtain subject-specific measures of morphometric brain connectivity, hypothesizing that sex-related differences in brain network global efficiency, or overall connectivity, would underlie observed cognitive differences. As predicted, females demonstrated better VM performance and males showed an advantage in SM. Females also demonstrated faster processing speed, with no observed sex difference in executive functioning. Males tended to have higher global efficiency, as well as higher regional connectivity (nodal strengths) in both the left and right hemispheres relative to females. Furthermore, higher global efficiency in males was found to mediate observed sex differences in cognition, predicting poorer verbal memory performance, better spatial memory, and slower processing speed in males. These findings contribute to an improved understanding of the way biological sex and differences in cognitive performance are related to morphometric brain connectivity as derived from graph-theoretic methods.

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Section: Discussionmentioning

confidence: 99%

Normative Sex Differences in Cognition and Morphometric Brain Connectivity: Evidence from 30,000+ UK Biobank Participants

Yang

Totzek

Lepage

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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Correlation between toxoplasmosis and schizophrenia in Egyptian patients and its impact on dopamine serum levels

Ammar,

Nabi,

El - ghani

2024

Acta Tropica

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Sex differences in cognition and structural covariance-based morphometric connectivity: evidence from 28,000+ UK Biobank participants

Yang,

Totzek,

Lepage

et al. 2023

Cerebral Cortex

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There is robust evidence for sex differences in domain-specific cognition, where females typically show an advantage for verbal memory, whereas males tend to perform better in spatial memory. Sex differences in brain connectivity are well documented and may provide insight into these differences. In this study, we examined sex differences in cognition and structural covariance, as an index of morphometric connectivity, of a large healthy sample (n = 28,821) from the UK Biobank. Using T1-weighted magnetic resonance imaging scans and regional cortical thickness values, we applied jackknife bias estimation and graph theory to obtain subject-specific measures of structural covariance, hypothesizing that sex-related differences in brain network global efficiency, or overall covariance, would underlie cognitive differences. As predicted, females demonstrated better verbal memory and males showed a spatial memory advantage. Females also demonstrated faster processing speed, with no observed sex difference in executive functioning. Males showed higher global efficiency, as well as higher regional covariance (nodal strengths) in both hemispheres relative to females. Furthermore, higher global efficiency in males mediated sex differences in verbal memory and processing speed. Findings contribute to an improved understanding of how biological sex and differences in cognition are related to morphometric connectivity as derived from graph-theoretic methods.

show abstract

Sex-specific associations in verbal memory brain circuitry in early psychosis

Cited by 3 publications

References 72 publications

Normative Sex Differences in Cognition and Morphometric Brain Connectivity: Evidence from 30,000+ UK Biobank Participants

Normative Sex Differences in Cognition and Morphometric Brain Connectivity: Evidence from 30,000+ UK Biobank Participants

Correlation between toxoplasmosis and schizophrenia in Egyptian patients and its impact on dopamine serum levels

Sex differences in cognition and structural covariance-based morphometric connectivity: evidence from 28,000+ UK Biobank participants

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