Sex‐specific association of plasma nesfatin‐1 concentrations with obesity in children

Dios, Olaya de; Herrero, Leticia; Gavela-Pérez, Teresa; Soriano‐Guillén, Leandro; Garcés, Cármen

doi:10.1111/ijpo.12567

Cited by 12 publications

(4 citation statements)

References 35 publications

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“…Regarding older children, five studies have explored serum nesfatin-1 levels in obese children (BMI > the 95th percentile) versus age- and sex-matched healthy children of normal weight. These results are conflicting, however [ 30 , 31 , 32 , 33 , 34 ]. One study reported significantly higher serum nesfatin-1 levels in obese children compared to normal-weight children [ 31 ] while the other studies reported significantly lower serum nesfatin-1 levels in obese children compared to normal-weight children (although one study only found this difference within girls) [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…These results are conflicting, however [ 30 , 31 , 32 , 33 , 34 ]. One study reported significantly higher serum nesfatin-1 levels in obese children compared to normal-weight children [ 31 ] while the other studies reported significantly lower serum nesfatin-1 levels in obese children compared to normal-weight children (although one study only found this difference within girls) [ 33 ]. A sixth study reported lower serum nesfatin-1 levels in healthy children who were underweight (defined as WAZ < 2 SD) and had poor appetite compared to healthy children with normal body weight [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry

et al. 2022

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Breastfed infants have different growth patterns to formula-fed infants and are less likely to develop obesity later in life. Nesfatin-1 is an anorexigenic adipokine that was discovered in human milk more than a decade ago, and its role in infant appetite regulation is not clear. Our aim was to describe nesfatin-1 levels in human milk collected 3–4 months postpartum, associations with infant anthropometry, and factors (maternal pre-pregnancy body mass index (mBMI), high weight gain during pregnancy, milk fat, and energy content) possibly influencing nesfatin-1 levels. We hypothesized that nesfatin-1 levels in mother’s milk would differ for infants that were large (high weight-for-age Z-score (WAZ)) or small (low WAZ) at the time of milk sample collection. We used enzyme-linked immunosorbent assay to detect the nesfatin-1 concentration in milk samples from mothers to high WAZ (n = 50) and low WAZ (n = 50) infants. We investigated associations between nesfatin-1 levels and infant anthropometry at 3–4 months of age and growth since birth, using linear regression adjusted for mBMI, birth weight, infant sex, and exclusivity of breastfeeding. We found no difference in nesfatin-1 levels between the two groups and no association with infant anthropometry, even after adjusting for potential confounders. However, high nesfatin-1 levels were correlated with low mBMI. Future research should investigate serum nesfatin-1 level in both mothers, infants and associations with growth in breastfed children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry

et al. 2022

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“…Various studies have investigated the relationship between nesfatin-1 levels and sex in children, but with different results. De Dios et al [29]indicated that nesfatin-1 concentrations were significantly lower in younger and older girls with obesity, while no significant differences were found in boys. In contrast, Kim et al [26] showed that nesfatin-1 levels were not significantly different between boys and girls; our finding fits well with the study of Kim et al, in which we found no significant difference in nesfatin-1 concentration between boys and girls.…”

Section: Discussionmentioning

confidence: 99%

Copeptin and Nesfatin-1 Are Interrelated Biomarkers with Roles in the Pathogenesis of Insulin Resistance in Chinese Children with Obesity

Chen

Liu

et al. 2020

Ann Nutr Metab

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Background: Copeptin and nesfatin-1 have recently been identified as novel peptides that play a role in the pathogenesis of obesity-related insulin resistance in adults. However, the relationship between them has not yet been elucidated, and their circulating levels in children with obesity have not been adequately studied. Therefore, the current study aimed to investigate whether their levels are altered in Chinese children with obesity, as well as to determine the correlation of these 2 peptides with each other, with insulin resistance, and with other biochemical parameters. Methods: A total of 156 children were enrolled in this study, including 101 children with obesity and 55 lean controls. Anthropometric parameters and clinical data of all subjects were collected, and circulating tumor necrosis factor-α, adiponectin, leptin, copeptin, and nesfatin-1 levels were measured using ELISA. Results: Serum copeptin and nesfatin-1 levels were significantly elevated in children with obesity and children with insulin resistance compared to control subjects. In addition, nesfatin-1 and copeptin levels were found to be significantly positively correlated with one another by Pearson’s correlation and partial correlation. In multiple regression analysis using nesfatin-1 or copeptin as the dependent parameter, a significant correlation was observed between nesfatin-1 and copeptin, and associations between each of them with homeostasis model assessment of insulin resistance (HOMA-IR) were detected. Conclusion: These novel findings shed light on the possible interplay role of these 2 molecules in obesity-related insulin resistance.

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“…Among them, nesfatin-1 is expressed in the central nervous system [7] , digestive system [8] , adipose tissue [9] , cardiovascular system [10] , etc. When it comes to the expression of nesfatin-1 in the reproductive system, mainly located in mouse OGCs, follicular membrane cells, endometrial epithelial cells and glands [11] , as well as testicular stromal cells [12] .…”

Section: Discussionmentioning

confidence: 99%

Effects of Nesfatin-1 and Wnt /β-Catenin Pathway on OGCs in PCOS

Ding¹,

D²,

K³

et al. 2020

Preprint

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Background Polycystic ovary syndrome is a complex disease related to the endocrine and metabolism. Its specific cause and pathogenesis have not been clear. Nesfatin-1 could not only regulate energy balance and glucose metabolism, but also affect the reproductive system. The Wnt/β-catenin signaling pathway affects follicle development, ovulation, corpus luteum formation, and steroid hormone production. Results Here, we studied the roles of nesfatin-1 and Wnt/β-catenin signaling pathway in the pathogenesis of polycystic ovary syndrome. Firstly, the human primary ovarian granulosa cells in vitro was cultured. The results showed that the apoptosis rate of ovarian granulosa cells in polycystic ovary syndrome patients was significantly higher than that of granular cells in normal people. Moreover, nesfatin-1 and Wnt/β-catenin pathway inhibitor IWR-1could inhibit the expressions of ovarian granulosa cells apoptosis genes and promote their proliferation, as well as nesfatin-1 affected the expressions of foxo3a and its downstream factors. Then, an in vitro culture system for ovarian granulosa cells (OGCs) was established by employing a rat model. The results are the same with those mentioned above. Conclusion This strongly proves that the nesfatin-1 participates in regulating the apoptosis and proliferation of granulosa cells by the Wnt/β-catenin pathway. According to the role of nesfatin-1 and IWR in polycystic ovary syndrome, nesfatin-1 and Wnt/β-catenin pathway can provide a guideline for the diagnosis and treatment of Polycystic ovary syndrome (PCOS).

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Sex‐specific association of plasma nesfatin‐1 concentrations with obesity in children

Cited by 12 publications

References 35 publications

Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry

Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry

Copeptin and Nesfatin-1 Are Interrelated Biomarkers with Roles in the Pathogenesis of Insulin Resistance in Chinese Children with Obesity

Effects of Nesfatin-1 and Wnt /β-Catenin Pathway on OGCs in PCOS

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