Sex-Specific Association of Age with Carotid Artery Distensibility: Multi-Ethnic Study of Atherosclerosis

Vaidya, Dhananjay; Heckbert, Susan R.; Wasserman, Bruce A.; Ouyang, Pamela

doi:10.1089/jwh.2011.3220

Cited by 13 publications

(18 citation statements)

References 15 publications

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“…7 Sex-related differences in the effects of antihypertensive therapy on distensibility progression may reflect lower control rates in older hypertensive women than men despite greater awareness and higher treatment rates among women. 18,19 Though some studies reported non-significant differences in control rates by sex, 20 our data shows that among treated hypertensives at baseline, men had better hypertension control.…”

Section: Discussionmentioning

confidence: 99%

“…2 Pathophysiological changes induced by hypertension include increased total peripheral resistance and decreased arterial compliance, ultimately limiting arterial distensibility. 2 An analysis from the Multi-Ethnic Study of Atherosclerosis (MESA) showed significant cross-sectional differences between the sexes in carotid distensibility; 7 however, longitudinal sex-related differences in age-related arterial stiffening and its predictors have not been described previously.…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness

Stern

Tattersall

Gepner

et al. 2015

ATVB

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Objective To identify sex differences in predictors of longitudinal changes in carotid arterial stiffness in a multi-ethnic cohort. Approach and Results Carotid artery distensibility coefficient (DC) and Young's Elastic Modulus (YEM) were measured in 2650 Multi-Ethnic Study of Atherosclerosis participants (45-84 years old and free of cardiovascular disease) at baseline and after a mean of 9.4 years. Predictors of changes in DC and YEM for each sex were evaluated using multivariable linear regression models. The 1236 men (46.6%) were 60.0 (standard deviation 9.3) years; 40% were White, 22% Black, 16% Chinese, and 22% Hispanic. The 1414 (53.4%) women were 59.8 (9.4) years old with a similar race distribution. Despite similar rates of change in DC and YEM, predictors of changes in distensibility markers differed by sex. In men, Chinese (p=0.002) and Black (p=0.003) race/ethnicity, systolic blood pressure (p=0.012), and diabetes mellitus (p=0.05) were associated with more rapidly decreasing DC (accelerated stiffening). Starting antihypertensive medication was associated with improved DC (p=0.03); stopping anti-hypertensives was associated with more rapid stiffening (increased YEM, p=0.05). In women, higher education was associated with slower stiffening (DC p=0.041; YEM p<0.001) as was use of lipid-lowering medication (p=0.03), whereas baseline use of antihypertensive medications (YEM p=0.01) and systolic blood pressure (DC p=0.02; p=0.04) predicted increasing stiffening in women. Conclusions Longitudinal changes in carotid artery stiffness are associated with systolic blood pressure and antihypertensive therapy in both sexes; however, race/ethnicity (in men) and level of education (in women) may have different contributions between the sexes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness

Stern

Tattersall

Gepner

et al. 2015

ATVB

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“…13 The slope Δ(logA)/ΔP was calculated directly within regression models adjusting for the confounders of both A and P in a single step. 14 The excursions from the mean of the systolic and diastolic pressures, together constituting pulse pressure as separate observations for each individual were added to the mixed regression model, while the mean of systolic and diastolic pressures was added as a covariate. Individual-level pulse-cycle mean log(area), as well as the individual level slope of log(area) vs. pressure between systole and diastole were estimated as random effects, and group-level differences in diameter and slopes are estimated as fixed effects.…”

Section: Methodsmentioning

confidence: 99%

Association of Parity With Carotid Diameter and Distensibility

et al. 2014

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Pregnancy and childbirth are associated with hemodynamic changes and vascular remodeling. It is not known whether parity is associated with later adverse vascular properties such as larger arterial diameter, wall thickness and lower distensibility. We used baseline data from 3283 women free of cardiovascular disease aged 45-84 years enrolled in the population based Multi-Ethnic Study of Atherosclerosis. Participants self-reported parity status. Ultrasound derived carotid artery lumen diameters and brachial artery blood pressures were measured at peak-systole and end-diastole. Common carotid intima media thickness (cIMT) was also measured. Regression models to determine the association of carotid distensibility coefficient, lumen diameter, and cIMT with parity were adjusted for age, race, height, weight, diabetes, current smoking, BP medication use, total and high density lipoprotein cholesterol levels. The prevalence of nulliparity was 18%. In adjusted models, carotid distensibility coefficient was 0.09 × 10−5Pa−1 lower (p = 0.009) in parous vs. nulliparous women. Among parous women, there was a nonlinear association with the greatest carotid DC seen in women with 2 live births, and significantly lower distensibility seen in primiparas (p=0.04) or with higher parity > 2 (p=0.005). No such pattern of association with parity was found for lumen diameter or cIMT. Parity is associated with lower carotid artery distensibility, suggesting arterial remodeling that lasts beyond childbirth. These long-term effects on the vasculature may explain the association of parity with cardiovascular events later in life.

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“…Larger carotid artery diameter has also been shown to be associated with aging and cardiovascular risk factors. [23] Other studies that have shown that BAD is associated with carotid artery diameter and left ventricular mass[24] as well as right ventricular mass. [25]…”

Section: Discussionmentioning

confidence: 99%

The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals

Vaidya

Král²,

Yanek³

et al. 2013

Coronary Artery Disease

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Objective Coronary atherosclerosis has been associated with systemic arterial remodeling even in non-atherosclerotic vessels. However it is not known whether systemic remodeling is differentially associated with the cumulative atherosclerotic process, reflected by putatively quiescent calcified plaque (CP) or with active atherosclerosis consisting of non-calcified plaque (NCP). We thus examined the association of brachial artery diameter (BAD), an artery which does not suffer clinical atherosclerosis, with the presence and the extent of coronary CP and NCP. Methods We studied 688 apparently healthy, asymptomatic participants from 350 families with a history of early-onset coronary artery disease (<60 years of age) measuring CAD risk factors and coronary plaque using dual-source CT angiography. Plaque volumes were quantified using a validated automated method. BAD was measured during diastole using B-mode ultrasound. The association of resting BAD with any detectable plaque, and log-transformed CP and NCP volumes if detectable, was tested using Generalized Estimating Equations (GEE) adjusted for age, sex, race, current smoking, diabetes, hypertension, body mass index, non-HDL and HDL-cholesterol. Results Higher quintiles of BAD were associated with greater age and male sex (both p <0.001). In fully adjusted analysis, CP volume was not associated with BAD (p=0.65) but 1 ml greater NCP volume was associated with 0.65 mm larger BAD (p=0.027). Conclusion Our results suggest that systemic arterial remodeling of non-atherosclerotic arteries is a dynamic process that is correlated with the extent of putatively active atherosclerotic processes in distant beds, but not inactive accumulated plaque burden.

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Sex-Specific Association of Age with Carotid Artery Distensibility: Multi-Ethnic Study of Atherosclerosis

Cited by 13 publications

References 15 publications

Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness

Sex Differences in Predictors of Longitudinal Changes in Carotid Artery Stiffness

Association of Parity With Carotid Diameter and Distensibility

The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals

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