Sex-specific association between infant diet and white matter integrity in 8-y-old children

Ou, Xiawei; Andres, Aline; Cleves, Mario A.; Pivik, R.T.; Snow, Jeffrey H.; Ding, Zhaohua; Badger, Thomas M.

doi:10.1038/pr.2014.129

Cited by 35 publications

(42 citation statements)

References 40 publications

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“…Results presented here extend previous findings of brain structural disparities in breast versus formula-fed children (Deoni, Dean, et al Ou et al, 2014) to cognitive differences, with suggestive negative associations between cognitive functioning and exclusive formula-feeding relative to breastfeeding, although these associations were insignificant after adjustment. Of note, no significant difference in cognition was found in association with mixed breast and formula feeding and exclusive breastfeeding, thus providing no evidence against the previously reported finding that even limited breastfeeding can positively influence early neurodevelopment relative to exclusive formula (Borra, Iacovou, & Sevilla, 2012).…”

Section: Discussionsupporting

confidence: 88%

Longitudinal associations between white matter maturation and cognitive development across early childhood

Dai

Hadjipantelis

Wang

et al. 2019

Human Brain Mapping

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From birth to 5 years of age, brain structure matures and evolves alongside emerging cognitive and behavioral abilities. In relating concurrent cognitive functioning and measures of brain structure, a major challenge that has impeded prior investigation of their time‐dynamic relationships is the sparse and irregular nature of most longitudinal neuroimaging data. We demonstrate how this problem can be addressed by applying functional concurrent regression models (FCRMs) to longitudinal cognitive and neuroimaging data. The application of FCRM in neuroimaging is illustrated with longitudinal neuroimaging and cognitive data acquired from a large cohort (n = 210) of healthy children, 2–48 months of age. Quantifying white matter myelination by using myelin water fraction (MWF) as imaging metric derived from MRI scans, application of this methodology reveals an early period (200–500 days) during which whole brain and regional white matter structure, as quantified by MWF, is positively associated with cognitive ability, while we found no such association for whole brain white matter volume. Adjusting for baseline covariates including socioeconomic status as measured by maternal education (SES‐ME), infant feeding practice, gender, and birth weight further reveals an increasing association between SES‐ME and cognitive development with child age. These results shed new light on the emerging patterns of brain and cognitive development, indicating that FCRM provides a useful tool for investigating these evolving relationships.

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Section: Discussionsupporting

confidence: 88%

Longitudinal associations between white matter maturation and cognitive development across early childhood

Dai

Hadjipantelis

Wang

et al. 2019

Human Brain Mapping

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“…Several studies have used DTI to establish links between white matter diffusion parameters and early environment, showing that white matter structure in childhood is linked to socioemotional deprivation in early life, pre and post‐partum maternal depressive symptoms, and infant nutrition, i.e. breastfeeding, among numerous other examples. A key area of future research will be to investigate how these environmental factors alter trajectories of development with age.…”

Section: Factors Contributing To Varying Development Ratesmentioning

confidence: 99%

A review of diffusion MRI of typical white matter development from early childhood to young adulthood

2017

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Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield parameters that may reflect alterations in the underlying neural micro-structure (e.g. myelination, axon density, fiber coherence), though it is limited by its lack of specificity and other methodological concerns. This review summarizes the last decade of diffusion imaging studies of healthy white matter development spanning childhood to early adulthood (4-35 years). Conclusions about anatomical location, rates, and timing of white matter development with age are discussed, as well as the influence of image acquisition, analysis, age range/sample size, and statistical model. Despite methodological variability between studies, some consistent findings have emerged from the literature. Specifically, diffusion studies of neurodevelopment overwhelmingly demonstrate regionally varying increases of fractional anisotropy and decreases of mean diffusivity during childhood and adolescence, some of which continue into adulthood. While most studies use linear fits to model age-related changes, studies with sufficient sample sizes and age range provide clear evidence that white matter development (as indicated by diffusion) is non-linear. Several studies further suggest that maturation in association tracts with frontal-temporal connections continues later than commissural and projection tracts. The emerging contributions of more advanced diffusion methods are also discussed, as they may reveal new aspects of white matter development. Although non-specific, diffusion changes may reflect increases of myelination, axonal packing, and/or coherence with age that may be associated with changes in cognition.

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“…In full term infants, magnetic resonance imaging (MRI) of the brain demonstrated greater white matter development from 10 months to 4 years 11 and at 8 years 12 ; and greater cortical thickness in adolescence 13 in relation to early breastfeeding exposure. In preterm infants, one small study 14 (n=50) found positive correlations of breast milk intake with total brain volume at 15 years of age.…”

mentioning

confidence: 99%

Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation

Belfort

Anderson

Nowak

et al. 2016

The Journal of Pediatrics

241

167

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Objectives To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants Study design We studied 180 infants born <30 weeks’ gestation or <1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001–2003. We calculated the number of days on which infants received >50% of enteral intake as breast milk from 0–28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at years. We adjusted for age, sex, social risk,7 and neonatal illness in linear regression. Results A greater number of days on which infants received >50% breast milk was associated with larger deep nuclear gray matter volume at term equivalent age (0.15 cc/day, 95% CI 0.05, 0.25); and with better performance at age 7 years on IQ (0.5 points/day, 95% CI 0.2, 0.8), mathematics (0.5, 95% CI 0.1, 0.9), working memory (0.5, 95% CI 0.1, 0.9), and motor function (0.1, 95% CI 0.0, 0.2) tests. No differences in regional brain volumes at 7 years in relation to breast milk intake were observed. Conclusion Predominant breast milk feeding in the first 28 days of life was associated with larger deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants.

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Sex-specific association between infant diet and white matter integrity in 8-y-old children

Cited by 35 publications

References 40 publications

Longitudinal associations between white matter maturation and cognitive development across early childhood

Longitudinal associations between white matter maturation and cognitive development across early childhood

A review of diffusion MRI of typical white matter development from early childhood to young adulthood

Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation

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