Sex-specific alterations in the gut and lung microbiome of allergen-induced mice
Carolyn Damilola Ekpruke,
Rachel Alford,
Dustin Rousselle
et al.
Abstract:IntroductionRecent evidence has demonstrated that the microbiome is a driver of the underlying pathophysiological mechanisms of respiratory disease. Studies have indicated that bacterial metabolites produced in the gut and lung can impact lung inflammation and immune cell activity, affecting disease pathology. Despite asthma being a disease with marked sex differences, experimental work linking microbiomes and asthma has not considered the sex variable.MethodsTo test the hypothesis that the lung and gut microb… Show more
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