Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles

Lovaković, Blanka Tariba; Barbir, Rinea; Pem, Barbara; Goessler, Walter; Ćurlin, Marija; Micek, Vedran; Debeljak, Željko; Božičević, Lucija; Ilić, Krunoslav; Pavičić, Ivan; Gorup, Dunja; Vrček, Ivana Vinković

doi:10.1016/j.impact.2021.100340

Cited by 9 publications

(6 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PVP-AgNPs and TRF-AgNPs (TRF = transferrin) administered to intact and gonadectomized B57Bl/6 adult mice produce oxidative damage in the lungs through ROS overproduction and GSH depletion on intact female and gonadectomized males compared to intact males and gonadectomized females. These results suggest a strong influence of serum progesterone levels on oxidative lung damage [39]. Gender-related differences in the biokinetic profile in blood and lung distribution have been found after intravenous administration of 15 nm PVP-AgNPs at concentrations of 7.5 to 120 mg/Kg of body weight in ICR mice.…”

Section: Gendermentioning

confidence: 73%

“…These provide AgNPs with inferred selectivity towards tumoral lung cells by interaction with specific tumoral receptors. This has been the case for many widely studied targets therapies in non-small lung cancer cells (e.g., EGFR and ROS1 mutations and ALK translocations) and several surface cell receptors in small cancer lung cells (e.g., PCRs, CXCR4, GLUT1, PETA/CD151, ALCAM/CD166, IGF1R and FGFRs, NCAM/CD56, RTK, ASCL1, SOX2, 4, and 11, OCT4, NANOG, PAX5, MYC) [38,39]. The surface functionalization of AgNPs is a critical factor that influences cellular uptake and their retention within the lungs [40].…”

Section: Surface Functionalizationmentioning

confidence: 99%

See 1 more Smart Citation

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

View full text Add to dashboard Cite

Nanomaterials (NMs) solve specific problems with remarkable results in several industrial and scientific areas. Among NMs, silver nanoparticles (AgNPs) have been extensively employed as drug carriers, medical diagnostics, energy harvesting devices, sensors, lubricants, and bioremediation. Notably, they have shown excellent antimicrobial, anticancer, and antiviral properties in the biomedical field. The literature analysis shows a selective cytotoxic effect on cancer cells compared to healthy cells, making its potential application in cancer treatment evident, increasing the need to study the potential risk of their use to environmental and human health. A large battery of toxicity models, both in vitro and in vivo, have been established to predict the harmful effects of incorporating AgNPs in these numerous areas or those produced due to involuntary exposure. However, these models often report contradictory results due to their lack of standardization, generating controversy and slowing the advances in nanotoxicology research, fundamentally by generalizing the biological response produced by the AgNP formulations. This review summarizes the last ten years’ reports concerning AgNPs’ toxicity in cellular respiratory system models (e.g., mono-culture models, co-cultures, 3D cultures, ex vivo and in vivo). In turn, more complex cellular models represent in a better way the physical and chemical barriers of the body; however, results should be used carefully so as not to be misleading. The main objective of this work is to highlight current models with the highest physiological relevance, identifying the opportunity areas of lung nanotoxicology and contributing to the establishment and strengthening of specific regulations regarding health and the environment.

show abstract

Section: Gendermentioning

confidence: 73%

Section: Surface Functionalizationmentioning

confidence: 99%

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Apart from industrial fields, AgNPs are widely used as an additive in vaccine adjuvant, anti-diabetic agents, wound healing, and anticancer therapy in medical applications ( Xu et al, 2020 ), which dramatically increased their possibility of human exposure. The liver is one of the primary organ responsible for the accumulation and detoxification of AgNPs from the body ( Recordati et al, 2016 ; Dong et al, 2020 ; Gan et al, 2020 ; Tariba Lovaković et al, 2021 ). AgNP-intoxication significantly disturbed liver function, elevated hepatic lipid peroxidation, increased liver DNA damage, and induced biochemical and histological alterations in rats ( Albrahim and Alonazi, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and Epigenetic Changes in Mice With NAFLD Induced by HFD

Wen

Lin

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The recent development of silver nanoparticles (AgNPs) has sparked increased interest in biomedical and pharmaceutical applications, leading to the possibility of human exposure. The liver is the primary target organ in the metabolism and transport of nanoparticles. Non-alcoholic fatty liver disease (NAFLD) is the most common and leading cause of hepatic metabolic syndrome with approximately 15% of patients will develop into non-alcoholic steatohepatitis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Thus, the potential hepatotoxicity of AgNPs on NAFLD development and progression should be of great concern. Herein, we explored the potential hepatic effect of a single intravenously injected dose of 0.5, 2.5, and 12.5 mg/kg BW on the liver function of high-fat-diet (HFD)-fed mice for 7 days. AgNP treatment increased serum levels of alanine aminotransferase, aspartate transaminase, triglycerides and cholesterols, the number of lipid droplets, and the contents of triglycerides and cholesterols in NAFLD mice livers compared to HFD-fed mice. The mechanism of AgNP-induced worsen hepatotoxicity in mice is associated with hyperactivation of SREBP-1c-mediated de novo lipogenesis and liver inflammation. Additionally, HFD-fed mice treated with AgNPs had significantly higher oxidative damage and lower global DNA methylation and DNA hydroxymethylation than NAFLD mice. This study suggests that AgNP treatment exacerbated HFD-induced hepatic steatosis, liver inflammation, oxidative stress, and epigenetic changes in mice, which is relevant to the risk of AgNP exposure on NAFLD development and progression.

show abstract

“…Figure 5b also shows the relatively high concentrations of silver in the lungs, exceeding the concentration of silver in the brain. The effect of silver nanoparticle accumulation in the lungs was also examined in [29], where mice were exposed to silver nanoparticles (size was around 10 nm) intraperitoneally for 21 days. This can be explained by a good blood supply to the lungs.…”

Section: Resultsmentioning

confidence: 99%

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Since ancient times, silver has been known for its pronounced bactericidal, antiviral and fungicidal properties. Currently, nanoparticles of this metal are widely used in the food, light and pharmaceutical industries, as well as in medicine. Silver in any form can have a toxic effect not only on pathogens, but also on healthy cells. The biological activity and bioavailability of silver preparations depend on the degree of their solubility in water. In addition, the maximum permissible concentration of soluble forms of silver is an order of magnitude lower than that of insoluble forms. This makes nanoparticles of silver with a hydrophilic coating that form stable colloidal solutions in aqueous media potentially unsafe objects. In this work, we studied the kinetics of the accumulation of silver nanoparticles with an average size of 34 ± 5 nm stabilized with polyvinylpyrrolidone in the organs of laboratory C57Bl/6 mice. The administration of nanoparticles was carried out orally for 30, 60, 120 and 180 days at the dose of 50 µg/day/animal. All the mice developed and gained weight normally during the experiment. No adverse effects were observed. Determination of the silver content in biological tissues of mammals was accomplished by neutron activation analysis. The masses and concentrations of silver in the brain and its different sections (hippocampus, cerebellum, cortex and remnants), as well as in the lungs, testes, liver, blood, kidneys, spleen and heart, were determined. The injection times at which the accumulation curves reached saturation were established. An extremely high accumulation of silver in the testes was shown at 120 days of administration, and a significant accumulation of silver in the lungs and brain was observed. The accumulation of silver in all parts of the brain except the cortex was significant, and its trend was similar to that in the whole brain.

show abstract

Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles

Cited by 9 publications

References 80 publications

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

Lung Models to Evaluate Silver Nanoparticles’ Toxicity and Their Impact on Human Health

AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and Epigenetic Changes in Mice With NAFLD Induced by HFD

Kinetics of Silver Accumulation in Tissues of Laboratory Mice after Long-Term Oral Administration of Silver Nanoparticles

Contact Info

Product

Resources

About