Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease

Picillo, Marina; Lafontant, David-Erick; Bressman, Susan; Caspell‐Garcia, Chelsea; Coffey, Christopher S.; Cho, Hyunkeun Ryan; Burghardt, Elliot; Dahodwala, Nabila; Sanders-Pullman, Rachel; Tanner, Caroline M.; Amara, Amy W.

doi:10.3233/jpd-212892

Cited by 16 publications

(17 citation statements)

References 41 publications

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“…A complex set of differences emerged from the comparison of gender‐related phenotypes. We found a slightly older AAO and milder motor symptoms in women, which was consistent with previous work 25‐27 suggesting a more benign PD motor phenotype in women than in men. Women had a higher rate of developing levodopa‐induced dyskinesias, which is in agreement with previous studies 28,29 .…”

Section: Discussionsupporting

confidence: 92%

The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics

et al. 2022

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Background There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history of PD in China. Objectives The objective of this study was to launch the Chinese Parkinson's Disease Registry (CPDR) and to report its protocol, cross‐sectional baseline data, and prospects for a comprehensive observational, longitudinal, multicenter study. Methods The CPDR recruited PD patients from 19 clinical sites across China between January 2018 and December 2020. Clinical data were collected prospectively using at least 17 core assessment scales. Patients were followed up for clinical outcomes through face‐to‐face interviews biennially. Results We launched the CPDR in China based on the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network (PD‐MDCNC). A total of 3148 PD patients were enrolled comprising 1623 men (51.6%) and 1525 women (48.4%). The proportions of early‐onset PD (EOPD, age at onset ≤50 years) and late‐onset PD (LOPD) were 897 (28.5%) and 2251 (71.5%), respectively. Stratification by age at onset showed that EOPD manifested milder motor and nonmotor phenotypes and was related to increased probability of dyskinesia. Comparison across genders suggested a slightly older average age at PD onset, milder motor symptoms, and a higher rate of developing levodopa‐induced dyskinesias in women. Conclusions The CPDR is one of the largest multicenter, observational, longitudinal, and natural history studies of PD in China. It offers an opportunity to expand the understanding of clinical features, genetic, imaging, and biological markers of PD progression. © 2022 International Parkinson and Movement Disorder Society.

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Section: Discussionsupporting

confidence: 92%

The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics

et al. 2022

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“…Recently, new data on gender differences in PD were obtained from the Parkinson’s Progression Markers Initiative (PPMI) database, an international, multiple-site, prospective, longitudinal cohort study. A 5-year longitudinal analysis of a subgroup of 423 patients (65.4% men) from the PPMI cohort showed: (a) a similar increase over time of MDS-UPDRS part III OFF scores in both sexes, with an increase over time of MDS-UPDRS part III ON scores only in men; (b) a significant increase over time in Levodopa equivalent dose (LED) in men as compared to women [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…Picillo, 1 [9] Longitudinal study (data obtained from the PPMI database) (2) lower tremor scores in coffee drinkers are found in both the male and female subgroups;…”

Section: Namentioning

confidence: 99%

Sex Differences in Parkinson’s Disease: From Bench to Bedside

et al. 2022

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Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences in PD regarding biomarkers, genetic factors, motor and non-motor symptoms, therapeutic management (including pharmacological and surgical treatment) as well as preclinical studies. Methods: A systematic literature review was performed by searching the Pubmed and Scopus databases with the search strings “biomarkers’’, ‘‘deep brain stimulation’’, “female”, ‘‘gender’’, ‘‘genetic”, ‘‘levodopa’’, ‘‘men’’, “male”, ‘‘motor symptoms’’, ‘‘non-motor symptoms’’, ‘‘Parkinson disease’’, ‘‘sex’’, ‘‘surgery’’, and ‘‘women’’. Results: The present review confirms the existence of differences between men and women in Parkinson Disease, pointing out new information regarding evidence from animal models, genetic factors, biomarkers, clinical features and pharmacological and surgical treatment. Conclusions: The overall goal is to acquire new informations about sex and gender differences in Parkinson Disease, in order to develop tailored intervetions.

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“…Incidence and prevalence of PD are between 1.5 and 2 times higher in men than in woman and disease onset in women is slightly later than in men [ 3 , 4 ]. Clinically, males have more rigidity and speech problems, whereas females seem to have a greater prevalence of dyskinesia and motor and non-motor response fluctuations but more mild motor deterioration [ 5 , 6 , 7 ]. Regarding non-motor symptoms (NMSs), some studies have observed that symptoms such as fatigue, depression, anxiety, and sleep problems are more frequent in females, whereas other NMSs such as drooling, diurnal somnolence, urinary and sexual dysfunction, and cognitive problems are more prevalent in males [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease

Santos‐García

Laguna

Hernández‐Vara

et al. 2023

JCM

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Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.

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Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease

Cited by 16 publications

References 41 publications

The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics

The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics

Sex Differences in Parkinson’s Disease: From Bench to Bedside

Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Disease

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