Sex-related impact on clinical outcomes of patients treated with drug-eluting stents according to clinical presentation: Patient-level pooled analysis from the GRAND-DES registry

Shin, Eun‐Seok; Jun, Eun Jung; Han, Jung‐Kyu; Kong, Min Gyu; Kang, Jeehoon; Zheng, Chengbin; Garg, Scot; Choi, Young Jin; Bae, Jang‐Whan; Chun, Kook‐Jin; Kim, Doo-Il; Rha, Seung Woon; Lee, Sung Yun; Rhew, Jay Young; Woo, Seong‐Ill; Lee, Han Cheol; Jeong, Jin‐Ok; Yang, Han–Mo; Park, Kyung Woo; Kang, Hyun–Jae; Koo, Bon‐Kwon; Chae, In‐Ho; Kim, Hyo–Soo

doi:10.5603/cj.a2021.0008

Cited by 2 publications

(2 citation statements)

References 34 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, our rates for minor bleeding (2.5% vs. 3.1%) and major bleeding (0.4% vs. 0.7%; p overall = 0.247) were comparable to other literature reports of Shin et al . [22]. We did not detect a gender difference in terms of bleeding events in contrast to other reports [23].…”

Section: Discussioncontrasting

confidence: 99%

“…Consequently, this may have contributed that we did not detect a significant difference in access site bleeding complications between females and males. Overall, our rates for minor bleeding (2.5% vs. 3.1%) and major bleeding (0.4% vs. 0.7%; p overall = 0.247) were comparable to other literature reports of Shin et al [22]. We did not detect a gender difference in terms of bleeding events in contrast to other reports [23].…”

Section: Bleeding Complicationssupporting

confidence: 85%

See 1 more Smart Citation

The effect of gender on clinical outcomes following routine revascularizations with polymer-free sirolimus-eluting stents

Krackhardt,

Yan,

Kherad

et al. 2023

Coronary Artery Disease

View full text Add to dashboard Cite

Background: Gender-specific outcomes after percutaneous coronary interventions were studied by a number of research groups with different endpoints and cohorts of different ethnic extractions. The purpose of this report is to use propensity score matching to determine gender-specific differences in clinical outcomes after percutaneous coronary interventions with polymer-free sirolimus-coated stents. Materials and methods: The basis for this post hoc analysis was two large all-comers studies with prospectively enrolled patients from Europe and Asia. Data were pooled and analyzed in terms of clinical outcomes to assess the impact of gender in patients with stable coronary artery disease and acute coronary syndrome. The primary endpoint was the accumulated target-lesion revascularization rate whereas secondary endpoints consisted of the event rates for major adverse cardiac events (MACE), myocardial infarction, bleeding events and death from all causes. The purpose of these post hoc analyses was to detect potential differences in clinical outcomes between females and males in unselected and propensity-score-matched cohorts. Results: Overall, in the unmatched cohorts, accumulated target-lesion revascularization rates did not differ between both genders (2.7% vs. 2.0%; P = 0.101), however, accumulated MACE rates were higher in females than in males (5.2% vs. 3.9%; P = 0.020). After propensity-score-matching, primarily adjusting for age, hypertension and diabetes, our data revealed similar accumulated MACE in women and men (5.5% vs. 5.2%; P = 0.749). In the unmatched STEMI subgroup, all-cause mortality was significantly higher in females driven by older age (P < 0.001). Conclusion: In the propensity-score-matched real-world cohorts, female gender was not a predictor for increased rates of accumulated MACE. In the unmatched STEMI subgroup, all-cause mortality was significantly higher in females due to older age. Age seems to be the determining factor for increased clinical event rates and not gender.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Bleeding Complicationssupporting

confidence: 85%