Sex-related human brain asymmetry in hemispheric functional gradients

Liang, Xinyu; Zhao, Chenxi; Jin, Xing‐Kun; Jiang, Yaya; Yang, Lei; Chen, Yijun; Gong, Gaolang

doi:10.1016/j.neuroimage.2021.117761

Cited by 39 publications

(48 citation statements)

References 77 publications

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“…Moreover, cortical gradients describe variations in genetic patterning 33,34 , functional processes 25,32,35 , and are observed across species 33,36,37 . Notably, recent research suggests that the principal gradient is asymmetric 9,38 and that the degree of asymmetry relates to individual differences in semantic performance and visual reasoning 38 .…”

Section: Introductionmentioning

confidence: 99%

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Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation

Wan

Bayrak

et al. 2021

Preprint

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The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, i.e., asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a hierarchical functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization. These asymmetries were heritable and comparable between humans and macaques, suggesting (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques and variable heritability in humans. This may reflect an evolutionary adaptation allowing for experience-dependent specialization, linked to higher-order cognitive functions uniquely developed in humans.

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Section: Introductionmentioning

confidence: 99%

“…The human cerebral cortex consists of two hemispheres that are not exactly alike and show marked differences in structure and function along a left-to-right axis [1][2][3][4][5][6][7][8][9] . It has been suggested that the brain favors asymmetry to avoid duplication of neural circuitry having equivalent functions 6,10 .…”

Section: Introductionmentioning

confidence: 99%

Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation

Wan

Bayrak

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…To our knowledge, the bilateral asymmetry of the MC has been rarely described in the literature among healthy people and patients with PTN. There is an asymmetry between the two hemispheres of the human brain, including the cortical projection area associated with the trigeminal nerve, such as the posterior central gyrus, cingulate gyrus, and paracentral gyrus [ 38 – 40 ]. Whether the asymmetry of the MC shape is related to the volume or thickness of the cerebral cortex deserves further study.…”

Section: Discussionmentioning

confidence: 99%

Flatness of the Meckel cave may cause primary trigeminal neuralgia: a radiomics-based study

Lin

Zhang

et al. 2021

J Headache Pain

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Background Neurovascular contact (NVC) is the main cause of primary trigeminal neuralgia (PTN); however, cases of PTN without NVC are still observed. In this study, the Meckel cave (MC) morphology in PTN were analyzed by radiomics and compared to healthy controls (HCs) to explore the cause of PTN. Methods We studied the 3.0T MRI data of 115 patients with PTN and 46 HCs. Bilateral MC was modeled using the 3D Slicer software, and the morphological characteristics of MC were analyzed using the radiomics method. Results The right side incidence rate in the PTN group was higher than the left side incidence. By analyzing the flatness feature of MC, we observed that the affected side of the PTN was lower than that of the unaffected side, the right MC of the PTN and HC was lower than that of the left MC, the MC of the affected side of the left and right PTN without bilateral NVC was lower than that of the unaffected side. Conclusions By providing a method to analyze the morphology of the MC, we found that there is an asymmetry in the morphology of bilateral MC in the PTN and HC groups. It can be inferred that the flatness of the MC may be a cause of PTN.

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“…To our knowledge, the bilateral asymmetry of MC has been rarely described in the literature among healthy people and patients with PTN. There is an asymmetry between the two hemispheres of the human brain, including the cortical projection area associated with the trigeminal nerve (such as the posterior central gyrus, cingulate gyrus, and paracentral gyrus) [38][39][40] . Whether the asymmetry of the MC shape is related to the volume or thickness of the cerebral cortex deserves further study.…”

Section: Discussionmentioning

confidence: 99%

Flatness of the Meckel Cave May Cause Primary Trigeminal Neuralgia: a Radiomics-based Study

Lin

Zhang

et al. 2021

Preprint

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Background: Neurovascular contact (NVC) is the main cause of primary trigeminal neuralgia (PTN); however, cases of PTN without NVC are still observed. In this study, the Meckel cave (MC) morphology in PTN were analyzed by radiomics and compared to healthy controls (HCs) to explore the cause of PTN.Methods: We studied the 3.0T MRI data of 115 patients with PTN and 46 HCs. Bilateral MC was modeled using the 3Dslicer software, and the morphological characteristics of MC were analyzed using the radiomics method.Results: The right side incidence rate in the PTN group was higher than the left side incidence. By analyzing the flatness feature of MC, we observed that the affected side of the PTN was lower than that of the unaffected side, the right MC of the PTN and HC was lower than that of the left MC, the MC of the affected side of the left and right PTN without bilateral NVC was lower than that of the unaffected side.Conclusions: By providing a method to analyze the morphology of MC, we found that there is asymmetry in the morphology of bilateral MC in the PTN and HC groups. It can be inferred that the flatness of MC may be a cause of PTN.

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Sex-related human brain asymmetry in hemispheric functional gradients

Cited by 39 publications

References 77 publications

Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation

Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation

Flatness of the Meckel cave may cause primary trigeminal neuralgia: a radiomics-based study

Flatness of the Meckel Cave May Cause Primary Trigeminal Neuralgia: a Radiomics-based Study

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