Sex-related differences in the regeneration of sensory axons and recovery of nociception after peripheral nerve crush in the rat

Kovačič, Uroš; Žele, Tilen; Osredkar, Joško; Sketelj, Janez; Bajrović, Fajko F.

doi:10.1016/j.expneurol.2004.05.015

Cited by 35 publications

(24 citation statements)

References 63 publications

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“…In any case, direct comparisons of plasma hormone values with our data are difficult as we are unaware of any prior measures of progesterone and estradiol following high cervical SCI in rats. Nevertheless, the values reported here are within the ranges of previous reports (Freeman, 1994;Kovacic et al, 2004) and the data confirm that pre-conditioning with OVX reduced plasma progesterone and estradiol compared to females receiving only C2HS.…”

Section: Sex Hormones and Respiratory Recoverysupporting

confidence: 90%

Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats

Doperalski

Sandhu

Bavis

et al. 2008

Respiratory Physiology & Neurobiology

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Female sex hormones influence the neural control of breathing and may impact neurologic recovery from spinal cord injury. We hypothesized that respiratory recovery after C2 spinal hemisection (C2HS) differs between males and females and is blunted by prior ovariectomy (OVX) in females. Inspiratory tidal volume (VT), frequency (fR), and ventilation (VE) were quantified during quiet breathing (baseline) and 7% CO 2 challenge before and after C2HS in unanesthetized adult rats via plethysmography. Baseline breathing was similarly altered in all rats (reduced VT, elevated fR) but during hypercapnia females had relatively higher VT (i.e. compared to pre-injury) than male or OVX rats (p < 0.05). Phrenic neurograms recorded in anesthetized rats indicated that normalized burst amplitude recorded ipsilateral to C2HS (i.e. the crossed phrenic phenomenon) is greater in females during respiratory challenge (p < 0.05 vs. male and OVX). We conclude that sex differences in recovery of VT and phrenic output are present at 2 weeks post-C2HS. These differences are consistent with the hypothesis that ovarian sex hormones influence respiratory recovery after cervical spinal cord injury.

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Section: Sex Hormones and Respiratory Recoverysupporting

confidence: 90%

Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats

Doperalski

Sandhu

Bavis

et al. 2008

Respiratory Physiology & Neurobiology

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“…Moreover, different experimental models of acquired peripheral neuropathies have shown gender-related differences on function and recovery of nociception (Joseph and Levine 2003a,b;Kovacic et al 2004). Finally, as recently observed, CMT women show higher disability (especially in measurements related to symptoms and pain) than men (Padua et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Neuroactive Steroid Levels in a Transgenic Rat Model of CMT1A Neuropathy

et al. 2008

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Charcot-Marie-Tooth type 1A (CMT1A) represents 80% of all the demyelinating hereditary motor and sensory neuropathies. As recently suggested, neuroactive steroids may have a role in a therapeutic strategy for peripheral neuropathies, including CMT1A. To this aim, an accurate qualitative and quantitative analysis of neuroactive steroid levels in this disease could be extremely important to define effective pharmacological strategies. We here analyzed by liquid chromatography-tandem mass spectrometry the levels of neuroactive steroids present in the sciatic nerve of male and female peripheral myelin protein 22 transgenic rats (PMP22(tg) rats; i.e., an experimental model of CMT1A) and of the corresponding wild-type littermates. We observed that, both in PMP22(tg) rats and in the wild types, the levels of neuroactive steroids, such as progesterone, tetrahydroprogesterone (THP), isopregnanolone (3beta,5alpha-THP), testosterone, dihydrotestosterone, and 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol) are sexually dimorphic. It is interesting to note that the levels of 3beta,5alpha-THP and of 3alpha-diol, which are exclusively detectable in sciatic nerve of female and male rats, respectively, are strongly decreased in PMP22(tg) rats. 3beta,5alpha-THP and 3alpha-diol are modulators of gamma-amino butyric acid A receptor. Thus, the present findings may be considered an interesting background for experiments aimed to evaluate the possible therapeutic effects of modulators of this neurotransmitter receptor in male and female PMP22(tg) rats.

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“…The few existing studies of sex differences in nerve regeneration suggest that regeneration of myelinated neurons occurs more rapidly in females than males (Kovacic et al 2003;Kovacic et al 2004;Kovacic et al 2009). However, Tong and colleagues recently found no sex differences in axon regeneration of axotomized neurons (Tong et al 2015).…”

Section: Similar Gene Expression Changes After Peripheral Nerve Injurmentioning

confidence: 99%

Sex differences in gene regulation in the dorsal root ganglion after nerve injury

Stephens

Zhou

et al. 2017

Preprint

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Pain is a subjective experience derived from complex interactions among biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity and chronic pain prevalence are well established. However, the molecular causes underlying these sex dimorphisms are poorly understood particularly with regard to the role of the peripheral nervous system.Here we sought to identify shared and distinct gene networks functioning in the peripheral nervous systems that may contribute to sex differences of pain after nerve injury. We performed RNA-seq on dorsal root ganglia following chronic constriction injury of the sciatic nerve in male and female rats. Analysis from paired naive and injured tissues showed that 1456 genes were differentially expressed between sexes. Appreciating sex-related gene expression differences and similarities in neuropathic pain models may help to improve the translational relevance to clinical populations and efficacy of clinical trials of this major health issue.

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Sex-related differences in the regeneration of sensory axons and recovery of nociception after peripheral nerve crush in the rat

Cited by 35 publications

References 63 publications

Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats

Ventilation and phrenic output following high cervical spinal hemisection in male vs. female rats

Neuroactive Steroid Levels in a Transgenic Rat Model of CMT1A Neuropathy

Sex differences in gene regulation in the dorsal root ganglion after nerve injury

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