Sex-related differences in the effect of aluminum on calcium transport in the small intestine of the rat

Effect of aluminium on duodenal calcium transport in pregnant and lactating rats treated with bromocriptine

“…3), and discarding the PRL influence due to BrC treatment, we can infer that one of the major candidates to be responsible for the variations observed in Al effect is E2. In this regard, the results of present work would extend previous findings about the relationship between the effect of Al on duodenal Ca transport and circulating E2 levels in virgin rats [14].…”

“…Since it has been demonstrated that Al effect on intestinal Ca transport occurs upon mucosa-to-serosa Ca flux (JCa ms ) only at the duodenal level [14,22], this parameter was determined at the following times: day 5 of pregnancy, day 19 of pregnancy, day 2 of nursing and at day 9 of nursing in the respective experimental groups, by an everted in vitro duodenal sacs technique as previously described [14]. Briefly, rats were anesthetized with sodium pentobarbital (50 mg/kg, i.p.…”

“…In ovariectomized female rats treated with estrogen the studies of dose-response curves showed that the sensitivity to the effect of Al on JCa ms was raised with increasing 17b-estradiol serum levels, without changes in the maximum response [14].…”

Gender Differences in the Membrane Transport of Endogenous and Exogenous Compounds

“…The sensitivity to the inhibitory effect of aluminum on duodenal calcium flux is raised with increasing serum levels of 17␤-estradiol in ovariectomized female rats with no alterations in the maximal response, whereas the effect of aluminum on calcium flux in duodenal sacs is not dependent of serum testosterone levels in castrated male rats injected with testosterone. These results demonstrate that there are gender-associated differences in the inhibitory effect of aluminum on transluminal calcium transport in the duodenum of the rat (Orihuela et al, 1996).…”

The Influence of Estradiol and Diet on Small Intestinal Glucose Transport in Ovariectomized Rats

“…These findings correspond with the improved calcium status after providing estrogen therapy to postmenopausal women and young hypogonadal girls (27). The responses to estradiol correspond with gender-based differences for intestinal calcium absorption (28), colonic functions (29), and amino acid digestibility (30) and may underlay the wider variation in systemic availability exhibited by females for some oral drugs (31)(32)(33)(34).…”