Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users

Prashad, Shikha; Hammonds, Ryan; Wiese, Amanda L.; Milligan, Amber L.; Filbey, Francesca M.

doi:10.1016/j.drugalcdep.2020.107931

Cited by 7 publications

(4 citation statements)

References 94 publications

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“…Likewise, circulating sex hormones certainly contribute to effects of cannabis and cannabinoid administration (Castelli et al, 2014;Marusich et al, 2015;Struik et al, 2018;Winsauer et al, 2012). A 2020 study correlated functional magnetic resonance imaging (fMRI) measurements with cannabis use and responses to cannabis-related cues (Prashad et al, 2020), and while neural response did not differ between males and females, females did have stronger subjective craving relative to males.…”

Section: Sex and Gender Differences In Cud And Cwsmentioning

confidence: 99%

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

Kesner

Lovinger

2021

Journal of Neurochemistry

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Section: Sex and Gender Differences In Cud And Cwsmentioning

confidence: 99%

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

Kesner

Lovinger

2021

Journal of Neurochemistry

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“…Finally, there is a growing body of preclinical literature suggesting that sex chromosomes, and organizational and activational effects of gonadal hormones may affect the endocannabinoid system (Cooper & Craft, 2018). There is some clinical evidence suggesting differences in patterns of use and subjective responses to cannabis across menstrual cycle phases (Hanzal et al, 2019; Prashad et al, 2020). In addition, preclinical and clinical studies suggested differences in the metabolism and subjective effects of alcohol across menstrual cycle phases, although the literature is inconsistent (Thomasson, 1995).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the acute pharmacological and subjective effects of smoked cannabis combined with alcohol in young adults.

Wright¹,

Wickens²,

Ciano³

et al. 2021

Psychology of Addictive Behaviors

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This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. same acute pharmacological and subjective effects of alcohol and cannabis as males, after smoking less cannabis, which has potential implications for informing education and policy. Further research is warranted on sex differences in cannabis pharmacology, as well as the combined effects of alcohol and cannabis. Public Health Significance StatementDespite the highly prevalent co-use of alcohol and cannabis, particularly among young adults, sex differences in the pharmacological and subjective effects of co-use are not well understood. In a sample of regular alcohol and cannabis users, females experienced the same acute effects of alcohol and cannabis as males, after smoking significantly less cannabis. These findings may suggest sex differences in how males and females co-use alcohol and cannabis and experience their effects, which have potential important implications for informing education and policy.

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“…Thus, THC may affect females at weaker levels than males because most of the THC is retained rather than metabolized (Fattore & Fratta, 2010). Female users also demonstrate a differential neural response associated with greater subjective craving for cannabis, relative to males (Prashad et al, 2020). Given the differences in neuroanatomical structures related to learning and memory and cannabinoid receptor availability between males and females described above, there also may be differing cognitive effects of exogenous cannabinoid exposure by sex.…”

Section: Introductionmentioning

confidence: 99%

Female Sex as a Protective Factor in the Effects of Chronic Cannabis Use on Verbal Learning and Memory

Hirst

Vaughn

Arastu

et al. 2021

J Int Neuropsychol Soc

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Objective:The variability of findings in studies examining the effects of chronic cannabis use on neuropsychological functioning highlights the importance of examining contributing factors. Few studies examine the role of sex in the relationship between cannabis and neuropsychological functioning, despite known neurobiological structural differences between males and females. This study examined whether males and females experience differential cognitive effects of chronic cannabis use.Method:Chronic cannabis users (3+ days per week for >12 months, n = 110, 72% male) and non-users (n = 71, 39% male) completed a neuropsychological test battery. Two multivariate analyses of covariance (MANCOVAs) examined for sex differences in performance within users and non-users on neuropsychological tests, controlling for potential confounding variables. Bonferroni corrections were applied to adjust for multiple comparisons.Results:Male and female cannabis users did not differ in cannabis use variables. Female cannabis users performed better than males on multiple subtests of the California Verbal Learning Test-II (CVLT-II), a verbal learning and memory test. Male cannabis users performed better than female users on Trial 1 of the CVLT-II (p = .002), and Trail Making Test B (p = .001), which measure attention and cognitive flexibility, respectively. Non-user males and females performed comparably, with the exception of Trail Making Test B (p = .001).Conclusions:Results suggest that chronic cannabis use differentially impacts males and females, with females exhibiting better verbal learning and memory despite males demonstrating better attention and cognitive flexibility. Further research is needed to understand the potential protective mechanism of female sex on learning and memory effects of cannabis use.

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Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users

Cited by 7 publications

References 94 publications

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

Sex differences in the acute pharmacological and subjective effects of smoked cannabis combined with alcohol in young adults.

Female Sex as a Protective Factor in the Effects of Chronic Cannabis Use on Verbal Learning and Memory

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