Sex-related differences in spatial learning during the early postnatal development of the rat

Cimadevilla, José Manuel; González-Pardo, Héctor; López, Laudino; Díaz, Francisca; Cueto, Eduardo García; García‐Moreno, Luis Miguel; Árias, Jorge L.

doi:10.1016/s0376-6357(99)00034-0

Cited by 40 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there was a main effect of Sex [ F (1,36) = 4.3, P <0.05], with females overall taking less time to locate the hidden platform. This result runs counter to typical reports wherein female rodents consistently perform worse than males on MWM and related spatial tasks [43]–[45]. This unusual result may be explained by a significant Strain × Sex interaction [ F (1,36) = 5.1, P <0.05], indicating the sex effect was driven by mutant females (Figure 4B).…”

Section: Resultscontrasting

confidence: 94%

A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe Neuronal Migration Disorder

et al. 2013

View full text Add to dashboard Cite

Disruption of neuronal migration in humans is associated with a wide range of behavioral and cognitive outcomes including severe intellectual disability, language impairment, and social dysfunction. Furthermore, malformations of cortical development have been observed in a number of neurodevelopmental disorders (e.g. autism and dyslexia), where boys are much more commonly diagnosed than girls (estimates around 4 to 1). The use of rodent models provides an excellent means to examine how sex may modulate behavioral outcomes in the presence of comparable abnormal neuroanatomical presentations. Initially characterized by Rosen et al. 2012, the BXD29- Tlr4lps−2J/J mouse mutant exhibits a highly penetrant neuroanatomical phenotype that consists of bilateral midline subcortical nodular heterotopia with partial callosal agenesis. In the current study, we confirm our initial findings of a severe impairment in rapid auditory processing in affected male mice. We also report that BXD29- Tlr4lps−2J/J (mutant) female mice show no sparing of rapid auditory processing, and in fact show deficits similar to mutant males. Interestingly, female BXD29- Tlr4lps−2J/J mice do display superiority in Morris water maze performance as compared to wild type females, an affect not seen in mutant males. Finally, we report new evidence that BXD29- Tlr4lps−2J/J mice, in general, show evidence of hyper-social behaviors. In closing, the use of the BXD29- Tlr4lps−2J/J strain of mice – with its strong behavioral and neuroanatomical phenotype – may be highly useful in characterizing sex independent versus dependent mechanisms that interact with neural reorganization, as well as clinically relevant abnormal behavior resulting from aberrant neuronal migration.

show abstract

Section: Resultscontrasting

confidence: 94%

A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe Neuronal Migration Disorder

et al. 2013

View full text Add to dashboard Cite

show abstract

“…These authors described male superiority in 8-year-old children. Therefore, it is accepted that during the postnatal development, spatial memory is dimorphic in humans as well as other species (Cimadevilla et al, 1999;León et al, 2014;Newhouse et al, 2007;Roof, 1993).…”

Section: Discussionmentioning

confidence: 99%

Spatial learning in a virtual reality-based task is altered in very preterm children

Cimadevilla

Roldán

París

et al. 2014

Journal of Clinical and Experimental Neuropsychology

View full text Add to dashboard Cite

Very preterm births prevent a complete development of the nervous system. The hippocampus is especially vulnerable in this population since the perinatal period is critical for its growth and development. Learning and memory abilities, like spatial memory, depend on the hippocampal integrity. In this study we applied virtual-reality-based tasks to assess spatial memory in a sample of 20 very preterm children of 7 and 8 years of age. Two different conditions of difficulty were used. Very preterm children performed poorly in the task in comparison with the control group. They committed more errors than controls searching for the rewarded positions. However, no significant differences were observed in the mean speed, an index of the motor abilities and joystick handling. These results suggest that the hippocampal function is affected in this sample. Nevertheless, other variables to consider are discussed.

show abstract

“…D 3 and D 1 receptor co-expressing cells were essentially absent in the female groups regardless of age. Interestingly, a previous study in periadolescent rats showed that spatial learning in males was significantly better than in females (Cimadevilla et al 1999). The mammillary body is also involved in spatial working memory, and the medial mammillary nuclei, in particular, is considered a relay center for the theta rhythms generated in the hippocampus (Vann and Aggleton 2004).…”

Section: Discussionmentioning

confidence: 94%

Molecular characterization of individual D3 dopamine receptor-expressing cells isolated from multiple brain regions of a novel mouse model

Liu

Kuzhikandathil

2012

Brain Struct Funct

View full text Add to dashboard Cite

Among dopamine receptors, the expression and function of the D3 receptor subtype is not well understood. The receptor has the highest affinity for dopamine and many drugs that target dopamine receptors. In this paper, we examined, at the single cell level, the characteristics of D3 receptor-expressing cells isolated from different brain regions of male and female mice that were either 35 or 70 days old. The brain regions included nucleus accumbens, Islands of Calleja, olfactory tubercle, retrosplenial cortex, dorsal subiculum, mammillary body, amygdala and septum. The expression analysis was done in the drd3-enhanced green fluorescent protein transgenic mice that report the endogenous expression of D3 receptor mRNA. Using single cell reverse transcriptase PCR, we determined if the D3 receptor-expressing fluorescent cells in these mice were neurons or glia and if they were glutamatergic, GABAergic or catecholaminergic. Next, we determined if the fluorescent cells co-expressed the four other dopamine receptor subtypes, adenylate cyclase V (ACV) isoform, and three different isoforms of G protein-coupled inward rectifier potassium (GIRK) channels. The results suggest that D3 receptor is expressed in neurons, with region-specific expression in glutamatergic and GABAergic neurons. The D3 receptor primarily co-expressed with D1 and D2 dopamine receptors with regional, sex and age-dependent differences in the co-expression pattern. The percentage of cells co-expressing D3 receptor and ACV or GIRK channels varied significantly by brain region, sex and age. The molecular characterization of D3 receptor-expressing cells in mouse brain reported here will facilitate the characterization of D3 receptor function in physiology and pathophysiology.

show abstract

Sex-related differences in spatial learning during the early postnatal development of the rat

Cited by 40 publications

References 34 publications

A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe Neuronal Migration Disorder

A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe Neuronal Migration Disorder

Spatial learning in a virtual reality-based task is altered in very preterm children

Molecular characterization of individual D3 dopamine receptor-expressing cells isolated from multiple brain regions of a novel mouse model

Contact Info

Product

Resources

About