Sex-Related Differences in Plasma Oxytocin Levels in Humans

Marazziti, Donatella; Baroni, Stefano; Mucci, Federico; Piccinni, Armando; Moroni, Ilenia; Giannaccini, Gino; Carmassi, Claudia; Massimetti, Enrico; Dell’Osso, Liliana

doi:10.2174/1745017901915010058

Cited by 42 publications

(25 citation statements)

References 69 publications

(77 reference statements)

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“…This supports previous findings showing highly complex actions of OXT with regard to sex differences in behavior (Caldwell, 2018). OXT levels and OXT release tend to be higher in females (Kramer et al, 2004;Carter, 2007;Marazziti et al, 2019). However, regulation of systems that rely on OXT seem to be sexually dimorphic in some species, but not all (Kramer et al, 2004), while sex differences in behavior are seldomly associated with structural changes in the OXT system (Caldwell, 2018).…”

Section: Discussionsupporting

confidence: 90%

Social Feedback During Sensorimotor Synchronization Changes Salivary Oxytocin and Behavioral States

et al. 2020

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Section: Discussionsupporting

confidence: 90%

Social Feedback During Sensorimotor Synchronization Changes Salivary Oxytocin and Behavioral States

et al. 2020

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“…Baseline serum oxytocin levels were higher in women (0.123 ± 0.130 ng/ml) than in men (0.042 ± 0.052 ng/ml) as reported previously ( Imamura et al , 2017 ; Marazziti et al , 2019 ). The educational background was slightly higher in men (11.43 ± 2.53 years) than in women (9.41 ± 1.63 years).…”

Section: Resultssupporting

confidence: 84%

Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Orihashi

Mizoguchi

Imamura

et al. 2020

Brain Communications

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Oxytocin is deeply involved in human relations. In recent years, it is becoming clear that oxytocin is also involved in social cognition and social behavior. Oxytocin receptors are also thought to be present in the hippocampus and amygdala, and the relationship between oxytocin and the structure and function of the hippocampus and amygdala has been reported. However, few studies have investigated oxytocin and its relationship to hippocampus and amygdala volume in elderly people. The aim of this study is to investigate the association between serum oxytocin levels and hippocampus and amygdala volume in elderly people. The survey was conducted twice in Kurokawa-cho, Imari, Saga Prefecture, Japan, among people aged 65 and older. We collected data from 596 residents. Serum oxytocin level measurements, brain MRI, Mini-Mental State Examination and Clinical Dementia Rating were performed in Time 1 (2009–2011). Follow-up brain MRI, Mini-Mental State Examination and Clinical Dementia Rating were performed in Time 2 (2016–2017). The interval between Time 1 and Time 2 was about 7 years. Fifty-eight participants (14 men, mean age 72.36 ± 3.41 years, oxytocin 0.042 ± 0.052 ng/ml; 44 women, mean age 73.07 ± 4.38 years, oxytocin 0.123 ± 0.130 ng/ml) completed this study. We analyzed the correlation between serum oxytocin levels (Time 1) and brain volume (Time 1, Time 2, and Time 1–2 difference) using voxel-based morphometry implemented with Statistical Parametric Mapping. Analysis at the cluster level (family-wise error; P < 0.05) showed a positive correlation between serum oxytocin levels (Time 1) and brain volume of the region containing the left hippocampus and amygdala (Time 2). This result suggests that oxytocin in people aged 65 and older may be associated with aging-related changes in hippocampus and amygdala volume.

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“…Social gender determinants make reference to socially constructed meanings with respect to being male or female, and these meanings include ways of feeling, wanting, thinking, and behaving specified for women and men (Oakley, 2016). The level of serotonin and its connection with pituitary hormones (oxytocin and gonadotropin), gonadal estrogens (estradiol and testosterone), and adrenal estrogens (dehydroepiandrosterone) have been studied as determinants of affective states (Luo et al., 2017; Marazziti et al., 2019; Susman et al., 1991). In present study, the effect sizes of sex and career on affective balance and NA were small as well as the effect size of sex on PA; thus, it would not necessarily require the establishment of specific population reference ranges for the groups defined by these two variables.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Mexican Spanish Version of the Scale of Positive and Negative Experience in a Sample of Medical and Psychology Students

Daniel-González¹,

Rubia

et al. 2019

Psychol Rep

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The Scale of Positive and Negative Experience (SPANE) aims to measure affect with high transcultural validity. The bifactor model is the best theoretical option to represent affective balance, although it is not typically used in validation studies. The objectives of this research were to test a bifactor model vis-à-vis the traditional model composed of two correlated factors, to prove its invariance across sexes, and to provide evidence of concurrent validity. A nonprobability sample composed of 600 Mexican students of psychology and medicine was recruit. One-group and multigroup confirmatory factor analyses were carried out. The SPANE and the scales selected to assess depression, perceived stress, and satisfaction with life were applied. The bifactor model showed better goodness-of-fit indices than the two correlated factors model: Δχ2(11) = 121.436, p < . 001, Δχ2/Δ df = 11.04 > 5, Δ GFI = .034, Δ NFI = .025, Δ NNFI = .022, and Δ CFI = .023 >.01. The internal consistency for the general factor as well as for the factor of positive affect was excellent, whereas it was good for the factor of negative affect. The measurement model was valid across sexes. The general factor of affective balance had a very high correlation with depression, high with perceived stress, and medium with satisfaction with life. It is concluded that SPANE is reliable and shows evidence of validity among Mexican student of psychology and medicine, and the bifactor model is adequate to represent affective balance.

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Sex-Related Differences in Plasma Oxytocin Levels in Humans

Cited by 42 publications

References 69 publications

Social Feedback During Sensorimotor Synchronization Changes Salivary Oxytocin and Behavioral States

Social Feedback During Sensorimotor Synchronization Changes Salivary Oxytocin and Behavioral States

Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study

Validation of the Mexican Spanish Version of the Scale of Positive and Negative Experience in a Sample of Medical and Psychology Students

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