Sex-related differences in immune development and the expression of atopy in early childhood

Uekert, Sara; Akan, Gökçe; Evans, Michael D.; LI, Z; Roberg, K.A.; TISLER, C; DaSilva, D.F.; Anderson, Elizabeth; Gangnon, Ronald E.; Allen, David J.

doi:10.1016/j.jaci.2006.09.008

“…This is consistent with previously published findings, and is likely due to gender differences in airway physiology and higher thresholds of methacholine airway response. 12 The results of our atmospheric pollution measurements revealed low exposure, as reported by Kalabokas et al, 1 who found that BTX levels in the vicinity of an oil refinery were lower than those detected in major Greek urban areas.…”

Section: Discussionsupporting

confidence: 80%

“…[10][11][12] In children under the age of 5, the diagnosis of asthma is quite complex, and the diagnostic approach is based on wheezing symptoms. 13 The presence of wheezing and associated risk factors over a 12-month period has been used as a measure of asthma prevalence in epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

Sibilância em crianças e adolescentes vizinhos a uma indústria petroquímica no Rio Grande do Norte, Brasil

Moraes¹,

Ignotti²,

Artaxo³

et al. 2010

J. Pediatr. (Rio J.)

3

0

View full text Add to dashboard Cite

Objective: To examine the association between wheezing in children and adolescents and living downwind of the dispersion plume of atmospheric pollutants emitted by the Guamaré Petrochemical Complex, in the state of Rio Grande do Norte, Brazil. Methods:Cross-sectional study of wheezing in children and adolescents (aged 0 to 14 years) living in the vicinity of the Guamaré petrochemical complex in 2006. The standardized International Study of Asthma and Allergies in Childhood questionnaire was used, with additional questions concerning tobacco use, income, living conditions, and educational achievement. Daily concentrations of PM 10 , PM 2.5 , black carbon, SO 2 , NO 2 , O 3 , benzene, toluene, and xylenes were measured at a fixed monitoring station. According to their position relative to wind direction, communities present in the area affected by plant emissions were categorized into one of two groups, exposed communities and reference communities.Results: Two hundred and nine children and adolescents took part in the study. Mean daily concentrations of the monitored pollutants were consistently below established acceptable upper limits. The prevalence of wheezing in the 12 months prior to study was 27.3%. After adjustment, statistically significant associations were found between wheezing and living in exposed communities (adjusted odds ratio [OR adj ] 2.01; 95% confidence interval [95%CI] 1.01-4.01), male gender (OR adj 2.50; 95%CI 1.21-5.18), and age 0 to 6 years (OR adj 5.00; 95%CI 2.41-10.39). Conclusion:Even with low levels of atmospheric pollutants, respiratory symptoms in children and adolescents were associated with living downwind of a petrochemical plant. Male preschoolers were the most vulnerable group. (Rio J). 2010;86(4):337-344: Wheezing, children, adolescents, air pollution, petrochemicals. J Pediatr

show abstract

“…A identificação precoce de sibilância recorrente é importante pela redução da função pulmonar e da gravidade da expressão da doença na infância, que pode permanecer na idade adulta [10][11][12] . Para menores de 5 anos de idade, o diagnóstico da asma é complexo, e a abordagem é feita por meio de sintomas de sibilância 13 .…”

Section: Introductionunclassified

Wheezing in children and adolescents living next to a petrochemical plant in Rio Grande do Norte, Brazil

Moraes

¹

,

Ignotti

²

,

Artaxo

³

et al. 2010

View full text Add to dashboard Cite

Objective: To examine the association between wheezing in children and adolescents and living downwind of the dispersion plume of atmospheric pollutants emitted by the Guamaré Petrochemical Complex, in the state of Rio Grande do Norte, Brazil. Methods:Cross-sectional study of wheezing in children and adolescents (aged 0 to 14 years) living in the vicinity of the Guamaré petrochemical complex in 2006. The standardized International Study of Asthma and Allergies in Childhood questionnaire was used, with additional questions concerning tobacco use, income, living conditions, and educational achievement. Daily concentrations of PM 10 , PM 2.5 , black carbon, SO 2 , NO 2 , O 3 , benzene, toluene, and xylenes were measured at a fixed monitoring station. According to their position relative to wind direction, communities present in the area affected by plant emissions were categorized into one of two groups, exposed communities and reference communities.Results: Two hundred and nine children and adolescents took part in the study. Mean daily concentrations of the monitored pollutants were consistently below established acceptable upper limits. The prevalence of wheezing in the 12 months prior to study was 27.3%. After adjustment, statistically significant associations were found between wheezing and living in exposed communities (adjusted odds ratio [OR adj ] 2.01; 95% confidence interval [95%CI] 1.01-4.01), male gender (OR adj 2.50; 95%CI 1.21-5.18), and age 0 to 6 years (OR adj 5.00; 95%CI 2.41-10.39). Conclusion:Even with low levels of atmospheric pollutants, respiratory symptoms in children and adolescents were associated with living downwind of a petrochemical plant. Male preschoolers were the most vulnerable group. Resultados: Participaram do estudo 209 crianças e adolescentes. As concentrações médias diárias dos poluentes monitorados mantiveramse abaixo dos limites estabelecidos nos padrões de qualidade do ar. A prevalência de sibilos nos últimos 12 meses foi de 27,3%. Associações estatisticamente significantes com sibilos nos últimos 12 meses foram verificadas mesmo após ajustamentos para comunidades expostas [razão de chances (odds ratio, OR ajust ) = 2,01; intervalo de confiança de 95% (IC95%) 1,01-4,01], gênero masculino (OR ajust = 2,50; IC95% 1,21-5,18) e idade de 0 a 6 anos (OR ajust = 5,00; IC95% 2,41-10,39). J Pediatr (Rio J) Conclusão:Mesmo em baixas concentrações de poluentes atmosfé-ricos, a ocorrência de sintomas respiratórios em crianças e adolescentes nas comunidades no entorno de um PPQ esteve associada a residência na direção preferencial dos ventos, mostrando-se mais vulnerável o grupo de pré-escolares do gênero masculino.J Pediatr (Rio J). 2010;86(4):337-344

show abstract

“…Gender is a major factor influencing allergen-specific IgE responses (9)(10)(11) and their heritability (12). Genomewide analyses that did not account for potential gender effects have failed to identify unique chromosomal loci with significant evidence of linkage to any allergen-specific IgE (13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

Sex-stratified Linkage Analysis Identifies a Female-specific Locus for IgE to Cockroach in Costa Ricans

Hunninghake¹,

Lasky‐Su²,

Soto-Quirós³

et al. 2008

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: The basis for gender influences on allergen-specific IgEs is unclear. Objectives: To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region. Methods: Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between singlenucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families of white children in the Childhood Asthma Management Program (CAMP). Measurements and Main Results: Among all subjects, there was suggestive evidence of linkage (LOD > 2.72) to IgE to Ascaris (on chromosome 7q) and IgE to dust mite (on chromosomes 7p and 12q). In a sex-stratified analysis, there was significant evidence of linkage to IgE to cockroach on chromosome 5q23 (peak LOD, 4.14 at 127 cM) in female subjects. TSLP is located within the 1.5 LOD-unit support interval for this linkage peak and has female-specific effects on lung disease in mice. In a sex-stratified analysis, the T allele of single-nucleotide polymorphism rs2289276 in TSLP was associated with reductions in IgE to cockroach (in Costa Rican girls) and total IgE (in girls in Costa Rica and in CAMP; P value for sex-by-genotype interaction, ,0.01 in both studies). Conclusions: Consistent with findings in murine models, a variant in TSLP may have female-specific effects on allergic phenotypes.

show abstract

Sex-related differences in immune development and the expression of atopy in early childhood

Cited by 107 publications

References 49 publications

Sibilância em crianças e adolescentes vizinhos a uma indústria petroquímica no Rio Grande do Norte, Brasil

Sibilância em crianças e adolescentes vizinhos a uma indústria petroquímica no Rio Grande do Norte, Brasil

Wheezing in children and adolescents living next to a petrochemical plant in Rio Grande do Norte, Brazil

Sex-stratified Linkage Analysis Identifies a Female-specific Locus for IgE to Cockroach in Costa Ricans

Contact Info

Product

Resources

About