Sex-related differences in human cerebral hemodynamics

Marinoni, Marinella; Ginanneschi, A.; Inzitari, Domenico; Mugnai, S.; Amaducci, L.

doi:10.1111/j.1600-0404.1998.tb05961.x

Cited by 33 publications

(42 citation statements)

References 17 publications

(9 reference statements)

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“…Several investigators have previously described sex-related differences in CBF in humans (Grolimund, Seiler 1988, Vriens et al 1989, Marinoni et al 1998, Muller, Schimrigk 1994, Krejza et al 1999, Deegan et al 2009), although in most cases, the number of subjects tended to be relatively small and only a few studies reported on CBFV (Deegan et al 2009). Most studies report higher mean blood flow velocities in females over males; however it is questioned whether this difference is limited to specific ages (Vriens et al 1989, Krejza et al 1999).…”

Section: Influence Of Sexmentioning

confidence: 99%

“…It is also important to be aware that CBFV, EtCO2, CrCP and LF coherence do change with ageing when interpreting results from TFA. Above all, it is well known that PaCO2 is a potent determinant of CBF and also affects dynamic CA (Paulson, Strandgaard & Edvinsson 1990, Aaslid et al 1989, Katsogridakis et al 2013, Minhas et al 2016, Marinoni et al 1998). …”

Section: Influence Of Agementioning

confidence: 99%

“…Using this new resource, we have extracted normative values of ARI and phase, which are the main parameters of clinical interest (Panerai 2008), and have also, tested the hypotheses that these parameters are not influenced by age and sex. These hypotheses were tested following previous observations showing effect of age and sex on CA and CBFV (Vriens et al 1989, Marinoni et al 1998). …”

Section: Introductionmentioning

confidence: 99%

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The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

et al. 2016

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Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex.Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15-minute stabilisation, and a 5-minute baseline recording.Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males.Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes. Key wordsCerebral haemodynamics, cerebral autoregulation, ageing, sex differences, cerebral blood

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Section: Influence Of Sexmentioning

confidence: 99%

Section: Influence Of Agementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

et al. 2016

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“…TCD has been used in many central nervous system disorders to allow insight into cerebrovascular function. 10,11 Normative data exist for the mean flow in the circle of Willis vessels [12][13][14][15] and for CO 2 reactivity. 16 -18 It is not known how device dependent these data may be.…”

mentioning

confidence: 99%

Elevated Cerebral Blood Flow Velocities in Fabry Disease With Reversal After Enzyme Replacement

Moore

Altarescu

Ling

et al. 2002

Stroke

152

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Background and Purpose-Fabry disease is an X-linked inherited disorder resulting from a deficiency of ␣-galactosidase A. Cerebrovascular disease in Fabry disease includes small-vessel disease and larger-vessel ectasia in a predominantly posterior distribution. We assessed transcranial Doppler (TCD) blood flow velocities in naive and enzyme-treated Fabry patients. Methods-TCD was used to noninvasively examine patients with Fabry disease for abnormal cerebral blood flow velocities. TCD measurements were also made during CO 2 retention by breathholding to examine cerebrovascular vessel reactivity. Twenty-six patients were enrolled in a 6-month, double-blind, placebo-controlled trial of enzyme replacement therapy consisting of biweekly intravenous ␣-galactosidase A infusions, with a subsequent 18-month follow-up in an open-label trial. Statistical analysis consisted of applying a mixed-effects ANOVA model for correlated outcomes. Results-Peak velocity, mean velocity, pulsatility index, and resistance index were found to be significantly higher in patients compared with control subjects. When the individual vessels were considered, elevated flow velocities were found in the middle cerebral M1 branch and the posterior cerebral artery. Enzyme replacement therapy significantly decreased peak, mean, and end-diastolic velocities and flow acceleration at the 18-month follow-up time point. Conclusions-Patients

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“…Studies have shown that there is sex difference in cerebral dynamics. [16][17][18] The MCA blood flow velocity decreased significantly with age. 16,17,19,20 Slight correlation was found in Korean between diabetes and velocity at ICA.…”

Section: Discussionmentioning

confidence: 99%

A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population

Zhang

Huang

et al. 2006

J Hum Hypertens

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In order to verify the relationship between blood pressure and cerebral blood flow velocity in sub-clinical natural population, 1294 middle-aged and old Beijing rural residents were investigated in autumn 2002. For all subjects, systolic blood flow velocities (V s ) in common carotid artery (CCA), internal carotid artery (ICA) and middle cerebral artery (MCA) were detected with transcranial Doppler. Key factors such as anthropometry, medication use, blood pressure and blood biochemical analysis were investigated at the same time. After controlling for age, gender, diabetes, hypercholesterolaemia, smoking and body mass index, multivariate analysis showed that systolic blood pressure (SBP) correlated positively with V s at MCA and slight negatively correlated with at CCA. As blood pressure rose by 10 mm Hg, the V s at MCA increased by 1.63 cm/s. Duration of hypertension (HD) negatively correlated with V s at MCA (Po0.01). The V s at MCA in early-stage and chronic hypertensive patients were 92.971.9 and 84.172.3 cm/s, respectively. Antihypertensive treatment could modify the V s at MCA towards a normal level by lowering blood pressure. In conclusion, the effect of hypertension on cerebral blood flow is complex. V s at MCA positively correlated with SBP, but negatively related to HD. Antihypertensive treatment might be helpful to keep cerebral blood flow at a normal level.

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Sex-related differences in human cerebral hemodynamics

Abstract: A sex-dependent hemispheric difference in MV in the left MCA at rest (females>males) in the younger population subgroup was identified. These data support recent observations on anatomical differences between sexes, referring a proportionally larger Broca area in females compared to males.

Cited by 33 publications

References 17 publications

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

Elevated Cerebral Blood Flow Velocities in Fabry Disease With Reversal After Enzyme Replacement

A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population

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