Sex-race differences in the relationship between obesity and asthma: the behavioral risk factor surveillance system, 2000

Kim, Sunghye; Camargo, Carlos A.

doi:10.1016/s1047-2797(03)00054-1

Cited by 70 publications

(50 citation statements)

References 36 publications

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“…Thus, slight differences in asthma severity across BMI groups that were present at baseline became magnified during the follow-up interval. In some [26,37,38], but not all [27,30], studies, the link between obesity and asthma prevalence was particularly evident in females, and a similar sex-specific relationship with BMI has been reported for asthma severity [39]. However, in the present study population, sex was not a significant covariate in the multivariable analyses.…”

Section: Discussionsupporting

confidence: 70%

Influence of body mass index on the response to asthma controller agents

Peters‐Golden

Swern²,

Bird³

et al. 2006

European Respiratory Journal

431

281

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The incidence of asthma has been positively associated with obesity. Asthma comprises diverse ''phenotypes'' reflecting heterogeneity in a number of characteristics, including response to therapy. The present authors examined whether body mass index (BMI) influenced the response to placebo, as well as to two asthma controller medications.A post hoc analysis was performed, pooling data from four double-blind, placebo-controlled studies randomising 3,073 moderate asthmatic adults to montelukast (n51,439), beclomethasone (n5894) or placebo (n5740). The primary end point was asthma control days; other end points were forced expiratory volume in one second, b-agonist use and nocturnal awakening. Analyses were conducted using BMI classification into normal (,25.0 kg?m ; 16%) categories, as well as BMI as a continuous variable.The treatment groups were balanced for BMI, demographic characteristics and parameters of asthma control. The placebo response for all end points was generally lower with increasing BMI. Similarly, the response to the inhaled corticosteroid decreased, whereas the response to the leukotriene antagonist remained stable.In conclusion, post hoc data from the present study suggested that body mass index may influence the natural history of asthma control (as reflected by response to placebo) and may differentially influence response to the two active agents, warranting explicit testing in future prospective studies.

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Section: Discussionsupporting

confidence: 70%

Influence of body mass index on the response to asthma controller agents

Peters‐Golden

Swern²,

Bird³

et al. 2006

European Respiratory Journal

431

281

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“…150 The relationship between obesity and asthma has been observed consistently regardless of the ethnic origin of the studies' population. 150,[154][155][156][157] In a prospective study with the highest number of subjects and with the longest follow-up (135,000 Norwegians, follow-up for 21 years), the incidence of asthma increased 10% and 7% per unit increase in BMI in men and women, respectively. 158 Mechanistic studies.…”

Section: Figmentioning

confidence: 99%

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Manna

Jain

2015

Metabolic Syndrome and Related Disorders

813

541

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Obesity is gaining acceptance as a serious primary health burden that impairs the quality of life because of its associated complications, including diabetes, cardiovascular diseases, cancer, asthma, sleep disorders, hepatic dysfunction, renal dysfunction, and infertility. It is a complex metabolic disorder with a multifactorial origin. Growing evidence suggests that oxidative stress plays a role as the critical factor linking obesity with its associated complications. Obesity per se can induce systemic oxidative stress through various biochemical mechanisms, such as superoxide generation from NADPH oxidases, oxidative phosphorylation, glyceraldehyde auto-oxidation, protein kinase C activation, and polyol and hexosamine pathways. Other factors that also contribute to oxidative stress in obesity include hyperleptinemia, low antioxidant defense, chronic inflammation, and postprandial reactive oxygen species generation. In addition, recent studies suggest that adipose tissue plays a critical role in regulating the pathophysiological mechanisms of obesity and its related co-morbidities. To establish an adequate platform for the prevention of obesity and its associated health risks, understanding the factors that contribute to the cause of obesity is necessary. The most current list of obesity determinants includes genetic factors, dietary intake, physical activity, environmental and socioeconomic factors, eating disorders, and societal influences. On the basis of the currently identified predominant determinants of obesity, a broad range of strategies have been recommended to reduce the prevalence of obesity, such as regular physical activity, ad libitum food intake limiting to certain micronutrients, increased dietary intake of fruits and vegetables, and meal replacements. This review aims to highlight recent findings regarding the role of oxidative stress in the pathogenesis of obesity and its associated risk factors, the role of dysfunctional adipose tissue in development of these risk factors, and potential strategies to regulate body weight loss/gain for better health benefits.

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“…2 The association of greater increase in BMI during childhood with asthma is consistent with a small number of previous studies. 5,6,25 Authors of previous studies have sometimes emphasized stronger associations in female subjects compared with male subjects, often without formal statistical tests for a sex difference. Our point estimate, in fact, suggested a stronger association in male subjects compared with female subjects but we found no statistical evidence of a sex difference.…”

Section: Comparisons With Other Studiesmentioning

confidence: 99%

Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study

et al. 2007

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Background:Obesity and asthma are common disorders, and the prevalence of both has increased in recent decades. It has been suggested that increases in the prevalence of obesity might in part explain the increase in asthma prevalence. This study aims to examine the prospective association between change in body mass index (BMI) z-score between ages 5 and 14 years and asthma symptoms at 14 years. Methods: Data was taken from the Mater University Study of Pregnancy and its outcomes (MUSP), a birth cohort of 7223 mothers and children started in Brisbane (Australia) in 1981. BMI was measured at age 5 and 14 years. Asthma was assessed from maternal reports of symptoms at age 5 and 14 years. In this study analyses were conducted on 2911 participants who had information on BMI and asthma at both ages. Results: BMI z-score at age 14 and the change in BMI z-score from age 5 to 14-years were positively associated with asthma symptoms at age 14 years, whereas BMI z-score at age 5 was not associated with asthma at age 14. Adjustment for a range of early-life exposures did not substantially alter these findings. The association between change in BMI z-score with asthma symptoms at 14 years appeared stronger for male subjects compared with female subjects but there was no statistical evidence for a sex difference (P=0.36). Conclusions: Increase in BMI z-score between age 5 and 14 years is associated with increased risk of asthma symptoms in adolescence.

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Sex-race differences in the relationship between obesity and asthma: the behavioral risk factor surveillance system, 2000

Cited by 70 publications

References 36 publications

Influence of body mass index on the response to asthma controller agents

Influence of body mass index on the response to asthma controller agents

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study

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