Sex, race, and age distributions of mean aortic wall thickness in a multiethnic population-based sample

Rosero, Eric B.; Peshock, Ronald M; Khera, Amit; Clagett, Patrick; Lo, Hao S.; Timaran, Carlos H.

doi:10.1016/j.jvs.2010.10.073

Cited by 53 publications

(33 citation statements)

References 37 publications

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“…We observed that the association between aging and cf‐PWV cannot be explained by classic risk factors in brown and mainly in black women in the highest cf‐PWV quartile. Additionally, our results are in agreement with a study that included participants in the Dallas Heart Study30 who had a magnetic resonance imaging of the abdominal aorta that did not detect differences in aortic thickness among ethnic groups in men. However, black women had greater wall thickness than white or Hispanic women 30.…”

Section: Discussionsupporting

confidence: 91%

“…Additionally, our results are in agreement with a study that included participants in the Dallas Heart Study30 who had a magnetic resonance imaging of the abdominal aorta that did not detect differences in aortic thickness among ethnic groups in men. However, black women had greater wall thickness than white or Hispanic women 30. These differences might be explained by other factors, such as genetic background, novel cardiovascular risk factors, or socioeconomic/psychosocial factors.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Racial Differences in Arterial Stiffness are Mainly Determined by Blood Pressure Levels: Results From the ELSA‐Brasil Study

Baldo

Cunha

Ribeiro

et al. 2017

JAHA

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BackgroundBlack people have a higher risk of developing hypertension and presenting higher vascular stiffening. Our aim was to investigate whether the association between race and aortic stiffness could be explained by differences in the primary risk factors.Methods and ResultsWe analyzed data from 11 472 adults (mean age, 51.9±8.9; 53.8% female) self‐reported as white (n=6173), brown (n=3364), or black (n=1935). Their carotid‐to‐femoral pulse wave velocity (cf‐PWV) as well as clinical and anthropometric parameters were measured. cf‐PWV was higher in blacks than in whites or browns (men: white, 9.63±1.81; brown, 9.63±1.88; black, 9.98±1.99; women: white, 8.84±1.64; brown, 9.02±1.68; black, 9.34±1.91; P<0.05). However, this difference disappeared after adjustments for age, mean arterial pressure, heart rate, waist circumference, fasting glucose, and glomerular filtration rate (men: white, 9.68±1.54; brown, 9.68±1.50; black, 9.73±1.52; women: white, 8.93±1.32; brown, 8.98±1.29; black, 9.02±1.32; P>0.05). The association between race and arterial stiffness was significant for brown and black women in the highest cf‐PWV quartile, even after controlling for covariates. There were no differences in the age‐related increase in cf‐PWV among the racial groups after adjustment, confirming the strong effect of age and mean arterial pressure on cf‐PWV revealed by the multiple linear regression.ConclusionsRacial differences in cf‐PWV were mainly attributed to differences in mean arterial pressure and age, although they cannot fully explain the association between race and cf‐PWV in women in the highest cf‐PWV values. This suggests that therapeutic approaches to overcome the effects of aging on the vascular system should focus on blood pressure control, especially in the black population.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Racial Differences in Arterial Stiffness are Mainly Determined by Blood Pressure Levels: Results From the ELSA‐Brasil Study

Baldo

Cunha

Ribeiro

et al. 2017

JAHA

View full text Add to dashboard Cite

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“…Therefore, we extend to small arteries the previous demonstration that in large arteries, such as the aorta [28] or the carotid [29], ageing and hypertension had trophic effects on arterial wall. Concerning arterioles, previous imaging methods had already detected enlargement with age [30].…”

Section: Discussionmentioning

confidence: 61%

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Rosenbaum

Mattina

Koch

et al. 2016

Journal of Hypertension

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“…3 There are reports of age-related increases of arterial wall thickness (AWT) in several cross-sectional community-based studies; 4,5 however, rates of change in AWT among middle-aged and older adults have not been defined. Moreover, the relationship between AWT and aortic stiffness after accounting for cardiovascular risk factors has not been defined.…”

Section: Introductionmentioning

confidence: 99%

Evolution of Aortic Wall Thickness and Stiffness With Atherosclerosis

et al. 2015

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The study was performed to determine age, gender, and time-dependent changes in aortic wall thickness (AWT), and to evaluate cross-sectional associations between AWT and arterial stiffness in older adults. Three hundred seventy-one (371) longitudinal and 426 cross-sectional measurements of AWT from cardiovascular magnetic resonance (CMR) imaging studies conducted within the Multi-Ethnic Study of Atherosclerosis (MESA) were analyzed at two points in time: in 2000-2002 and then again from follow-up examinations in 2010-2012. Aortic wall thickness was determined from a double inversion recovery black-blood fast spin-echo sequence, and aortic stiffness was measured from a phase-contrast cine gradient echo sequence. The thickness of the mid-thoracic descending aortic wall was measured and correlated to distensibility of the ascending aorta (AAD) and aortic pulse wave velocity (PWV). The average rate of AWT change was 0.032mm per year. The increase in AWT was greater for those aged 45 to 54 years relative to individuals older than age 55 years (p-trend<0.001). Ascending aortic distensibility was lower (p<0.001) and PWV was higher (p=0.012) for hypertensive subjects. After adjustment for traditional risk factors, AAD was significantly related to AWT in participants without hypertension. Hypertension was associated with increased aortic stiffness independent of aortic wall thickness.

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Sex, race, and age distributions of mean aortic wall thickness in a multiethnic population-based sample

Abstract: Age, gender, and racial/ethnic differences in MAWT distributions exist in the general population. Such differences should be considered in future investigations assessing aortic atherosclerosis and the effects of anti-atherosclerotic therapies.

Cited by 53 publications

References 37 publications

Racial Differences in Arterial Stiffness are Mainly Determined by Blood Pressure Levels: Results From the ELSA‐Brasil Study

Racial Differences in Arterial Stiffness are Mainly Determined by Blood Pressure Levels: Results From the ELSA‐Brasil Study

Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics

Evolution of Aortic Wall Thickness and Stiffness With Atherosclerosis

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