Sex, parturition and motherhood without oxytocin?

Ja, Russell; Leng, Gareth

doi:10.1677/joe.0.1570343

Cited by 147 publications

(95 citation statements)

References 181 publications

(76 reference statements)

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“…From there, the hormone OT is released to affect reproductive function (Russell & Leng 1998, Fisher et al 2006) and maintain hydroelectrolytic homeostasis, which is regulated by changes in plasma osmolality (Balment et al 1980, McKinley & Johnson 2004. We found a significant increase in plasma osmolality in E 2 -primed and unprimed OVX animals that were refed with standard food after fasting when compared to animals fed ad libitum or animals that were fasted for 48 h. Our results are in keeping with the results of a previous study which showed that refeeding may increase plasma osmolality (Gill et al 1985, Burlet et al 1992.…”

Section: Discussionmentioning

confidence: 99%

Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity

Lucio-Oliveira¹,

Franci²

2011

Journal of Endocrinology

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Increased plasma osmolality by food intake evokes augmentation of plasma oxytocin (OT). Ovarian steroids may also influence the balance of body fluids by acting on OT neurones. Our aim was to determine if estrogen influences the activity of OT neurones in paraventricular nucleus (PVN) and supraoptic nucleus (SON) under different osmotic situations. Ovariectomized rats (OVX) were treated with either estradiol (E 2 ) or vehicle and were divided into three groups: group I was fed ad libitum, group II underwent 48 h of fasting, and group III was refed after 48 h of fasting. On the day of the experiment, blood samples were collected to determine the plasma osmolality and OT. The animals were subsequently perfused, and OT/FOS immunofluorescence analysis was conducted on neurones in the PVN and the SON. When compared to animals which were fasted or fed ad libitum, the plasma osmolality of refed animals was higher, regardless of whether they were treated with vehicle or E 2 . We observed neural activation of OT cells in vehicle-or E 2 -treated OVX rats refed after 48 h of fasting, but not in animals fed ad libitum or in animals that only underwent 48 h of fasting. Finally, the percentage of neurones that co-expressed OT and FOS was lower in both the PVN and the SON of animals treated with E 2 and refed, when compared to vehicle-treated animals. These results suggest that E 2 may have an inhibitory effect on OT neurones and may modulate the secretion of OT in response to the increase of osmolality induced by refeeding.

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Section: Discussionmentioning

confidence: 99%

Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity

Lucio-Oliveira¹,

Franci²

2011

Journal of Endocrinology

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“…The role of OT varies between different animal species. Although in rodents, OT is believed to play a significant role in the initiation and maintenance of parturition [13,23], in humans, circulating OT does not seem to be essential for the initiation and maintenance of labour [24]. Normal parturition has been observed in the absence of OT in mice [24] as well as in cases of clinical pituitary gland dysfunction [25] and the concentrations of maternal or fetal OT does not increase with the onset of or during labour [26].…”

Section: Previously Established Roles Of Ot/otr Systemmentioning

confidence: 99%

Advances in the role of oxytocin receptors in human parturition

Kim

Bennett

Terzidou

2017

Molecular and Cellular Endocrinology

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“…The name 'oxytocin' is derived from the Greek for 'quick birth', and though it plays a role in normal parturition in most species, there is enough redundancy in the systems controlling birth to allow birth to proceed in its absence (see Russell & Leng, 1998). But in the absence of oxytocin, a babe that sucks at a nipple will go hungry, even if the breast at which he sucks is engorged with milk.…”

Section: Two Peptides -How Many Functions?mentioning

confidence: 99%

Veni, vidi, vici: the neurohypophysis in the twentieth century

Russell

Leng

2000

Experimental Physiology

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We outline the key discoveries in the first 70 years of research on the neurohypophysis that provided the foundations for more recent studies in the last 30 years. We consider the extent to which these recent studies, which have exploited molecular technologies, cellular electrophysiological techniques and mechanistic behavioural investigations, have advanced or changed our understanding of the functions of oxytocin and vasopressin. The different evolutionary pressures on the oxytocin and vasopressin systems are discussed. Lastly, we focus on the mechanisms underlying the burst-firing activity of oxytocin neurones in lactation as a problem not yet solved, and probably requiring a presently improbable conceptual leap to understand. Experimental Physiology (2000) 85S, IS-6s.

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Sex, parturition and motherhood without oxytocin?

Cited by 147 publications

References 181 publications

Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity

Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity

Advances in the role of oxytocin receptors in human parturition

Veni, vidi, vici: the neurohypophysis in the twentieth century

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