Sex of Host as a Factor in Chagas' Disease

Hauschka, Theodore S.

doi:10.2307/3273675

Cited by 55 publications

(20 citation statements)

References 9 publications

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“…Although both sexes were probably exposed to the same maternal influence, females seem to control more effectively the decreased resistance. These findings are in agreement with classic literature data that showed that males are more susceptible to T. cruzi infection than females (Hauschka 1947, Rivera-Vanderpas et al 1983. We have observed that even in four week old mice, when maternal anti-T. cruzi antibodies could still be detected at protective levels, males were less resistant.…”

Section: Discussionsupporting

confidence: 93%

Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice

Araújo

Chiari²

1996

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 93%

Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice

Araújo

Chiari²

1996

Mem. Inst. Oswaldo Cruz

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“…In controls, the growth of the implants continued and eventually killed the mice. Out of the 45 mice used in the experiment, the implants completely disappeared in 30 of them, while in the rest (15), the implants showed a clear reduction in size; all 45 control mice died of tumors. "Trypanosome infection -Roskin concluded in 1931 -had a biotherapeutic effect on the growth of carcinomas in mice" (Roskin, Ekzempliarskaia, 1931, p.344).…”

Section: Trypanosoma Cruzi and Cancer In The Soviet Unionmentioning

confidence: 99%

“…They soon began preliminary experiments in collaboration with several NCI researchers. 15 Hauschka immediately tried to contact Roskin. On May 22nd, 1945, he sent Roskin a long letter, telling his Soviet colleague about Shear's program on tumor chemotherapy and his own role in the program.…”

Section: "Us Soviet To Share Research In Cancer"mentioning

confidence: 99%

Trypanosoma cruzi, cancer and the Cold War

Krementsov

2009

Hist. cienc. saude-Manguinhos

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In the summer of 1946, the international community of cancer researchers was inspired by the announcement that two Soviet scientists, Nina Kliueva and Grigorii Roskin, had discovered anticancer properties in culture extracts made from the South American protozoan, Trypanosoma cruzi, and had produced a preparation -named after its discoverers KR -which showed clear therapeutic effects on cancer patients. Research teams from various countries enthusiastically pursued the promising new line of investigation. The story of the rise and fall of interest in the anticancer properties of T. cruzi in different countries suggests that during the second half of the twentieth century, the Cold War competition between the superpowers played an important role in shaping the research agendas of cancer studies.

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“…The data obtained for parasitemia present significant differences and tendency observed in other studies recently carried out 3 , in which the animals which are submitted to physical training and then to infection respond better to the infectious agent. Sex 22 , age 23 and genetic constitution of the host can influence the infection course by the T. cruzi in vertebrates 24 . The genetic response of each strain and sex present interesting points to be elucidated in further research approaching the immunegenetics involved in defense mechanisms of the animals.…”

Section: Discussionmentioning

confidence: 99%

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Soares

Franzói-de-Moraes

et al. 2012

Rev Bras Med Esporte

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Background: Chagas disease is an infection caused by Trypanosoma cruzi that affects eight million people in Latin America. One factor linked to the lifestyle that significantly interferes in the response to infection is physical exercise, depending on the kind, intensity and frequency of the activity practiced. Objective: To evaluate the influence of pre-infection chronic moderate aerobic exercise in the development of experimental infection with T. cruzi in mice of two distinct lineages from both sexes. Methods: 30-day old Swiss and BALB/c mice (male and female) were divided into four groups for each strain and sex (total 16) and named as follows: SM (Swiss males), SF (Swiss females) BM (BALB/c mice) and BF (BALB/c mice). The groups were: NT NI (untrained uninfected) T NI (trained not infected); NT I (untrained infected), TI (trained infected). The aerobic exercise pre-moderate chronic infection training was performed with one daily session for eight weeks, five times a week. The inoculum was 1,400 blood trypomastigotes of Y strain of T. cruziintraperitoneally. The peak of parasites, parasitemia total and average measurements of the serum activities of CK and CK-MB were evaluated. Results and Conclusions: The physical training promoted reduction in peak, parasitemia parasites and total average in animals infected with T. cruzi in both strains and sexes. Physical training induced reduction in serum activities of CK and CK-MB in animals infected with T. cruzi of both sexes and from the two strains, except for females in the Swiss CK activity.

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Sex of Host as a Factor in Chagas' Disease

Cited by 55 publications

References 9 publications

Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice

Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice

Trypanosoma cruzi, cancer and the Cold War

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

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