Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease

Zhu, Guanyu; Zhang, Jianguo; Yuan, Tianshuo; Chen, Ying; Liu, Defeng; Ma, Ruoyu; Zhang, Xin; Du, Tingting

doi:10.4103/1673-5374.353506

Cited by 8 publications

(17 citation statements)

References 50 publications

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“…Although depressive symptoms appeared to decrease more in women than in men, further analysis showed significant modulation by gender, but not for STN-DBS time or the interaction between STN-DBS time and gender ( 27 ). Importantly, this and other studies consistently reported that women had more severe depressive symptoms than men before surgery ( 24 , 27 , 32 , 41 ). In general, most other studies showed equal improvement in depression in both genders ( 24 , 25 , 32 , 42 ).…”

Section: Resultssupporting

confidence: 77%

“…Importantly, this and other studies consistently reported that women had more severe depressive symptoms than men before surgery ( 24 , 27 , 32 , 41 ). In general, most other studies showed equal improvement in depression in both genders ( 24 , 25 , 32 , 42 ).…”

Section: Resultssupporting

confidence: 77%

“…Interestingly, Yuan et al demonstrated that both genders improved significantly in “OFF medication-ON stimulation” conditions, but only men improved in the “ON medication-ON stimulation” conditions. This was reported for total scores and most subscores, including the bradykinesia subscore ( 32 ).…”

Section: Resultsmentioning

confidence: 77%

“…Regarding depression, a total of seven studies were reviewed ( 24–27 , 32 , 41 , 42 ), with one study reporting greater improvement in depression in female patients ( 41 ) and one study reporting greater improvement in depression in male patients after STN-DBS ( 26 ). Furthermore, a longitudinal study reported that women had more depressive symptoms in all phases of STN-DBS surgery and LEDD was positively correlated with depressive symptoms only in women ( 27 ).…”

Section: Resultsmentioning

confidence: 99%

“…Anxiety was measured in two studies, with one study reporting higher anxiety symptoms in women before surgery ( 32 ), but neither study found significant improvement in anxiety in men or women after surgery ( 32 , 42 ).…”

Section: Resultsmentioning

confidence: 99%

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Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Hendriks,

Vinke,

Georgiev

2024

Front. Neurol.

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Available data suggest that there may be gender differences in the effect of STN-DBS in the treatment of Parkinson’s disease (PD). The aim of this study was to review data on gender discrepancies and gender differences in clinical outcomes in PD patients treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). Included were original studies that specifically examined gender discrepancies or gender differences in PD patients with STN-DBS. Men receive more DBS than women, for various indications. The decision-making process for DBS in women compared to men is more influenced by personal preferences and external factors. Motor symptoms improve in both genders, but bradykinesia improves more in men. The postoperative reduction of the levodopa equivalent daily dose seems to be more pronounced in men. Men show more cognitive deterioration and less improvement than women after STN-DBS. Women show more depressive symptoms before surgery, but they improve similarly to men. Men show more improvement in impulsivity and less decrease in impulsive behaviour symptoms than women. Anxiety and personality traits remain unchanged in both genders. Voice quality improves more in men and deteriorates less often than in women. Men gain fat-free mass and fat mass, but women only gain fat mass. Regarding sexual function the evidence is inconsistent. More urinary symptoms improve in women than in men. Pain and restless leg syndrome seems to improve more in men. Regarding quality of life, the evidence seems to be inconsistent, and activities of daily living seems to improve in both genders. Better prospective controlled studies, focusing directly on gender differences in PD patients treated with STN-DBS, are needed to better explain gender differences in STN-DBS for PD.

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Section: Resultssupporting

confidence: 77%

Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Hendriks,

Vinke,

Georgiev

2024

Front. Neurol.

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Outcome differences between males and females undergoing deep brain stimulation for treatment-resistant depression: systematic review and individual patient data meta-analysis

Patel,

Ramaiah,

Mamaril-Davis

et al. 2024

Journal of Affective Disorders

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The Effects of Subthalamic Nucleus Deep Brain Stimulation and Retention Delay on Memory-Guided Reaching Performance in People with Parkinson’s Disease

Trevarrow

Munoz

Rivera

et al. 2023

JPD

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Background: Subthalamic nucleus deep brain stimulation (STN-DBS) improves intensive aspects of movement (velocity) in people with Parkinson’s disease (PD) but impairs the more cognitively demanding coordinative aspects of movement (error). We extended these findings by evaluating STN-DBS induced changes in intensive and coordinative aspects of movement during a memory-guided reaching task with varying retention delays. Objective: We evaluated the effect of STN-DBS on motor control during a memory-guided reaching task with short and long retention delays in participants with PD and compared performance to healthy controls (HC). Methods: Eleven participants with PD completed the motor section of the Movement Disorder Society’s Unified Parkinson’s Disease Rating Scale (MDS-UPDRS III) and performed a memory-guided reaching task under four different STN-DBS conditions (DBS-OFF, DBS-RIGHT, DBS-LEFT, and DBS-BOTH) and two retention delays (0.5 s and 5 s). An additional 13 HC completed the memory-guided reaching task. Results: Unilateral and bilateral STN-DBS improved the MDS-UPDRS III scores. In the memory-guided reaching task, both unilateral and bilateral STN-DBS increased the intensive aspects of movement (amplitude and velocity) in the direction toward HC but impaired coordinative aspects of movement (error) away from the HC. Furthermore, movement time was decreased but reaction time was unaffected by STN-DBS. Shorter retention delays increased amplitude and velocity, decreased movement times, and decreased error, but increased reaction times in the participants with PD. There were no interactions between STN-DBS condition and retention delay. Conclusion: STN-DBS may affect cognitive-motor functioning by altering activity throughout cortico-basal ganglia networks and the oscillatory activity subserving them.

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Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease

Cited by 8 publications

References 50 publications

Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson’s disease with subthalamic deep brain stimulation

Outcome differences between males and females undergoing deep brain stimulation for treatment-resistant depression: systematic review and individual patient data meta-analysis

The Effects of Subthalamic Nucleus Deep Brain Stimulation and Retention Delay on Memory-Guided Reaching Performance in People with Parkinson’s Disease

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