Sex-Limited Hereditary Cancer in Lepidopterous Larvae

Federley, Harry

doi:10.1111/j.1601-5223.1936.tb02648.x

Cited by 27 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lepidopterans, birds), the prediction of which sex is affected diverge across models, allowing us to discriminate between the underlying explanations. In support of the nucleo-cytoplasmic incompatibility model, male killing has been found in the moth Pygaera pigra in crosses between males from Berlin and females from Finland, and has been shown to be due to a maternally inherited gene [81]. A role of Wolbachia in this example seems unlikely as the males died as late instar larvae from cancer-like growths although we cannot exclude it altogether.…”

Section: Factors That Counteract the Sex-specific Selective Sievementioning

confidence: 64%

The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

Beekman

Dowling

Aanen

2014

Phil. Trans. R. Soc. B

128

View full text Add to dashboard Cite

Eukaryotic cells typically contain numerous mitochondria, each with multiple copies of their own genome, the mtDNA. Uniparental transmission of mitochondria, usually via the mother, prevents the mixing of mtDNA from different individuals. While on the one hand, this should resolve the potential for selection for fast-replicating mtDNA variants that reduce organismal fitness, maternal inheritance will, in theory, come with another set of problems that are specifically relevant to males. Maternal inheritance implies that the mitochondrial genome is never transmitted through males, and thus selection can target only the mtDNA sequence when carried by females. A consequence is that mtDNA mutations that confer male-biased phenotypic expression will be prone to evade selection, and accumulate. Here, we review the evidence from the ecological, evolutionary and medical literature for male specificity of mtDNA mutations affecting fertility, health and ageing. While such effects have been discovered experimentally in the laboratory, their relevance to natural populations—including the human population—remains unclear. We suggest that the existence of male expression-biased mtDNA mutations is likely to be a broad phenomenon, but that these mutations remain cryptic owing to the presence of counter-adapted nuclear compensatory modifier mutations, which offset their deleterious effects.

show abstract

Section: Factors That Counteract the Sex-specific Selective Sievementioning

confidence: 64%

The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

Beekman

Dowling

Aanen

2014

Phil. Trans. R. Soc. B

128

View full text Add to dashboard Cite

show abstract

“…Harker (1958) reported excessive endocrine secretions from sub-oesophageal ganglion-induced tumors in the midgut of Periplaneta americana. Federley (1936) reported male-killing in the species hybrids of the butter y Pygaera pigra (Notodontitade: Lepidoptera). Male larvae of the species hybrids are killed due to cancer before they even reach pupation.…”

Section: Ortuño Et Al 2016mentioning

confidence: 99%

LC-MS/MS analysis of carcinogenic tobacco-specific nitrosamines in Spodoptera litura using the QuEChERS method

Karthik

Yashaswini

Morthala

et al. 2022

Preprint

View full text Add to dashboard Cite

Nicotine is a highly addictive alkaloid and a neurostimulator found in tobacco that causes addiction in humans and makes tobacco a high-demand commercial product. It is popularly used for recreational purposes and is not a harmful substance except for the addiction it causes. The metabolites of nicotine such as the Tobacco-specific Nitrosamines (TSNAs) are hazardous substances whose metabolites are highly electrophilic and form DNA adducts, which will initiate the process of carcinogenesis. TSNAs are formed during curing, storage and fermentation due to the nitrosation of nicotine and other tobacco alkaloids. TSNAs are used as biomarkers for cancer risk assessment in humans exposed to tobacco and its products. To determine the occasional formation of TSNAs in tobacco-feeding insects, 5th instar larvae of Spodoptera litura and their faeces were analyzed for the presence of NNN, NNK, and NNAL along with the stored tobacco leaves (PT-76) using an Agilent 6470B LC-MS/MS system following ISO/DIS 19290:2015 protocol. The LOD and LOQ were 0.001 mg/kg and 0.005 mg/kg for all the tested nitrosamines. NNN was found to be 0.365 mg/kg, 0.344 mg/kg, and 5.71 mg/kg in insect whole-body samples, faeces, and tobacco leaves, respectively. NNK was found to be 0.062 mg/kg, 0.036 mg/kg and 0.97 mg/kg in insect whole body samples, faeces and tobacco leaves, respectively. However, NNAL was not detected in both the insect’s whole body and faeces. Recoveries ranged between 95-98% for all compounds when spiked at LOD and LOQ. The presence of TSNAs is a biomarker for cancer risk and their presence in insects would point to cancer risk assessment in tobacco feeding insects and any possible TSNA-detoxifying pathways in insects that might prevent mutagenesis caused these compounds.

show abstract

“…after circa 1900-1930) there were several parallel discoveries of deterministically biased transmission (e.g. Correns 1902;Gershenson 1928;Heribert-Nilsson 1920;Metz and Moses 1923;Morgan et al 1925), including sex ratio distorters (Simmonds 1923a(Simmonds , b, 1926(Simmonds , 1928 with one such observation possibly as early as 1911 (Federley 1911(Federley , 1936. For consideration of Renner's extensive work on non-Mendelian inheritance in Oenothera, see Sturtevant (1926).…”

Section: The Slow Rise Of Non-mendelian Geneticsmentioning

confidence: 99%

A century of bias in genetics and evolution

Hurst

2019

Heredity

View full text Add to dashboard Cite

Mendel proposed that the heritable material is particulate and that transmission of alleles is unbiased. An assumption of unbiased transmission was necessary to show how variation can be preserved in the absence of selection, so overturning an early objection to Darwinism. In the second half of the twentieth century, it was widely recognised that even strongly deleterious alleles can invade if they have strongly biased transmission (i.e. strong segregation distortion). The spread of alleles with distorted segregation can explain many curiosities. More recently, the selectionist-neutralist duopoly was broken by the realisation that biased gene conversion can explain phenomena such as mammalian isochore structures. An initial focus on unbiased transmission in 1919, has thus given way to an interest in biased transmission in 2019. A focus on very weak bias is now possible owing to technological advances, although technical biases may put a limit on resolving power. To understand the relevance of weak bias we could profit from having the concept of the effectively Mendelian allele, a companion to the effectively neutral allele. Understanding the implications of unbiased and biased transmission may, I suggest, be a good way to teach evolution so as to avoid psychological biases.

show abstract

Sex-Limited Hereditary Cancer in Lepidopterous Larvae

Cited by 27 publications

References 11 publications

The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

The costs of being male: are there sex-specific effects of uniparental mitochondrial inheritance?

LC-MS/MS analysis of carcinogenic tobacco-specific nitrosamines in Spodoptera litura using the QuEChERS method

A century of bias in genetics and evolution

Contact Info

Product

Resources

About