Sex hormones and risk of epilepsy: A bidirectional Mendelian randomization study

Ke, Bin; Li, Chunyu; Shang, Huifang

doi:10.3389/fnmol.2023.1153907

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Statistical analysis for MR: The causal relationship between exposure variables and outcome variables was assessed using inverse variance weighted median (IVW). IVW is the main method commonly used in MR studies, which summarizes the magnitude of the effect of individual SNPs on the symptoms (Wald ratios) through the inverse variance weighted median pattern in meta-analysis, and ultimately evaluates causality across all the IVs and outcome variables [22] .…”

Section: Research Design 1 Mendelian Randomizationmentioning

confidence: 99%

The relationship between zinc and epilepsy

Luo,

Liu,

et al. 2024

Preprint

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Background Previous studies have indicated a potential relationship between zinc and epilepsy. The aim of this study is to investigate the causal relationship between zinc, zinc-dependent carbonic anhydrase, and gray matter volume in brain regions enriched with zinc, in relation to epileptic seizures, as well as explore the possible mechanisms by which zinc contributes to epilepsy. Methods First, this study assessed the risk causality between zinc, carbonic anhydrase, and gray matter volume alterations in zinc-enriched brain regions and various subtypes of epilepsy based on two-sample Mendelian randomization analysis. And then, Then, this study conducted GO/KEGG analysis based on colocalization analysis, MAGMA analysis, lasso regression, random forest model and xgboot model. Results 1. There was a causal relationship between zinc, carbonic anhydrase-4, and generalized epilepsy (p = 0.044, p = 0.010). Additionally, carbonic anhydrase-1 and gray matter volume of the caudate nucleus were found to be associated with epilepsy and focal epilepsy (p = 0.014, p = 0.003, p = 0.022, p = 0.009).2. A colocalization relationship was found between epilepsy and focal epilepsy (PP.H4.abf = 97.7e-2). MAGMA analysis indicated that SNPs associated with epilepsy and focal epilepsy were functionally localized to zinc-finger-protein-related genes (p < 1.0e-5).3. The genes associated with focal epilepsy were found to have a molecular function of zinc ion binding (FDR = 1.9e-4). Within 4 to 24 hours after experiencing epilepsy, the function of the gene whose expression changed in the rats with focal epilepsy was enriched in the biological process of vascular response (FDR = 4.0e-5), compared to the rats without seizure. Conclusion The mechanism of the increased risk of epilepsy caused by zinc may be related to the increase of zinc ion-dependent carbonic anhydrase or the increase of the volume of zinc-rich caudate gray matter.

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Section: Research Design 1 Mendelian Randomizationmentioning

confidence: 99%

The relationship between zinc and epilepsy

Luo,

Liu,

et al. 2024

Preprint

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Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy

Luo,

Liu,

et al. 2024

J Mol Neurosci

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Prevalence and forms of sexual dysfunctions in Egyptian men with epilepsy in Helwan

Abou Elmaaty,

El Sherifi,

Elserafy

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Background Although there is a striking impact of epilepsy on sexual functions, this issue is avoided by the patients, because they consider it as a taboo that brings much shame to the complainer and also largely ignored by physicians and neurologists who involved in epileptic patient management. Our aim was to investigate the prevalence and forms of sexual dysfunction (SD) in Egyptian men with epilepsy and relating this dysfunction to the type of epilepsy and the existing sex hormone disturbance. Methods We recruited seventy male epileptic patients on anti-seizure medications and seventy healthy males aged-matched control subjects. We assessed their sexual functions using IIEF-15. Results The prevalence of SD in epileptic patients in our study was as follows: erectile function (64.3%), sexual desire (45.7%), intercourse satisfaction (37.2%) and orgasmic function (15.7%). We found statistically significant lower IIEF scores in uncontrolled versus controlled epileptic patients, in spite that total and free testosterone were not statistically significantly different between the two groups. Although a lower IIEF score in focal versus generalized epilepsy was noticed, but only orgasmic function achieved statistical significance (P = 0.049). Our results exhibited no statistically significant difference as regard treatment therapy in relation to sexual function and hormonal plasma level. Conclusions A higher prevalence of sexual dysfunction was observed in the epileptic patients especially in those with uncontrolled seizures. For that reason, the issues related to sexual activity should be clarified by physicians how are involved in managing the patients suffering from epilepsy.

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Sex hormones and risk of epilepsy: A bidirectional Mendelian randomization study

Cited by 3 publications

References 28 publications

The relationship between zinc and epilepsy

The relationship between zinc and epilepsy

Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy

Prevalence and forms of sexual dysfunctions in Egyptian men with epilepsy in Helwan

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