Sex Hormones and Macronutrient Metabolism

Comitato, Raffaella; Saba, Anna; Turrini, Aida; Arganini, Claudia; Virgili, Fabio

doi:10.1080/10408398.2011.651177

Cited by 66 publications

(49 citation statements)

References 176 publications

(191 reference statements)

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“…It has been suggested that sex itself (sex hormones affect the amount and distribution of body fat) is a factor influencing body composition, its oxidation and mobilization [20]. In our study, the increased risk to males may also be due to the different pattern of PA [19] or to different dietary habits of men and women.…”

Section: Discussionmentioning

confidence: 64%

General and Abdominal Obesity Is Related to Physical Activity, Smoking and Sleeping Behaviours and Mediated by the Educational Level: Findings from the ANIBES Study in Spain

López-Sobaler¹,

Rodríguez-Rodríguez²,

Aranceta-Bartrina³

et al. 2016

PLoS ONE

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The aim of the present study was to analyze the association of socioeconomic (SES) and lifestyle factors, with the conditions of overweight (OW), general (OB) and abdominal obesity (AO) in Spanish adults. A representative sample of 1655 Spanish adults (18 to 65 years) from the ANIBES Study was investigated. Collected data included measured anthropometry (weight, height and waist circumference), demographic and SES data (region and habitant population size, educational level, family income, unemployment rate), physical activity (PA) and other lifestyle factors (sleeping time and frequency of viewing television). OW, OB and AO were determined in each participant. Being male, older than 40 years, and watching television more frequently were associated with higher risk of OB and AO, whereas those with a higher level of education, smokers, and more time in sleeping and in vigorous PA, but not in moderate-vigorous PA, were associated with a lower risk. Living in the Atlantic region and stating no answer to the question regarding family income were also associated with lower risk of AO. Strategies for preventing and reducing OB and AO should consider improving sleeping habits and PA. They should also pay more attention to the most vulnerable groups such as those less educated.

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Section: Discussionmentioning

confidence: 64%

General and Abdominal Obesity Is Related to Physical Activity, Smoking and Sleeping Behaviours and Mediated by the Educational Level: Findings from the ANIBES Study in Spain

López-Sobaler¹,

Rodríguez-Rodríguez²,

Aranceta-Bartrina³

et al. 2016

PLoS ONE

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“…Sieber and Spradling (10) recently revealed that ecdysone‐ and EcR‐mediated signaling controls lipid metabolism, to establish a female metabolic state and to promote whole‐body triglyceride storage, which has been linked to increased survival (49). The presence of sex steroid hormones in humans is also recognized as playing a major role in establishing sex‐specific differences in body composition (50). Prunetin led to an increase in fat body mass, as indicated by an upregulation of total triglycerides of 29% compared with controls (Fig.…”

Section: Discussionmentioning

confidence: 99%

The phytoestrogen prunetin affects body composition and improves fitness and lifespan in maleDrosophila melanogaster

2015

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Dietary isoflavones, a group of secondary plant compounds that exhibit phytoestrogenic properties, are primarily found in soy. Prunetin, a representative isoflavone, was recently found to affect cell signaling in cultured cells; however, in vivo effects remain elusive. In this study, the model organism Drosophila melanogaster was used to investigate the effects of prunetin in vivo with respect to lifespan, locomotion, body composition, metabolism, and gut health. Adult flies were chronically administered a prunetin-supplemented diet. Prunetin improved median survival by 3 d, and climbing activity increased by 54% in males. In comparison with the females, male flies exhibited lower climbing activity, which was reversed by prunetin intake. Furthermore, prunetin-fed males exhibited increased expression of the longevity gene Sirtuin 1 (Sir2) (22%), as well as elevated AMPK activation (51%) and triglyceride levels (29%), whereas glucose levels decreased (36%). As females are long-lived compared with their male counterparts and exhibit higher triglyceride levels, prunetin apparently "feminizes" male flies via its estrogenicity. We conclude that the lifespan-prolonging effects of prunetin in the male fruit fly depend on changes in AMPK-regulated energy homeostasis via male "feminization." Collectively, we identified prunetin as a plant bioactive compound capable of improving health status and survival in male D. melanogaster.-Piegholdt, S., Rimbach, G., Wagner, A. E. The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogaster. FASEB J. 30, 948-958 (2016). www.fasebj.orgDiet plays an important role in health and in the prevention of chronic diseases (1). The traditional Asian diet is rich in fruits, vegetables, and legumes, including soy. Soy is the most important dietary source of isoflavones, and prunetin is a representative of the isoflavone group that exhibits potent bioactivity (2). Although it has been demonstrated in cultured cells in vitro that prunetin may affect cell signaling, little is known about its bioactivity in vivo. We investigated whether prunetin affects health and lifespan in the model organism Drosophila melanogaster, given that inflammation, stress response, barrier function, and metabolism have been described as crucial determinants of longevity. In this context, D. melanogaster is an appropriate model for investigating the effects of plant bioactives on metabolism, inflammation, and aging, because genes that affect common biologic processes and molecular functions are evolutionarily conserved. Drosophila exhibits orthologs of most mammalian genes. Furthermore, numerous Drosophila protein sequences are similar to those of mammals (3). In addition, the fruit fly possesses a complex, dynamic gut that is similar in structure and organization to the mammalian gut (4). Insect immune function has much in common with the innate immune response of mammals, and the fruit fly is an accepted model for investigating innate immunity [reviewed i...

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“…As such, reproductive‐steroid‐induced changes in the metabolome, small molecules that are fundamental to cell signaling and function, may represent a significant albeit indirect means by which steroids regulate processes relevant for brain and behavior. Animal and cell culture studies, in fact, suggest both sex differences and an effect of reproductive steroids in the metabolism of proteins that affect a broad range of pathological and physiological events (Comitato, Saba, Turrini, Arganini, & Virgili, ; Smith et al., ).…”

Section: Discussionmentioning

confidence: 99%

Progesterone and plasma metabolites in women with and in those without premenstrual dysphoric disorder

Florio

Alexander

Schmidt³

et al. 2018

Depress Anxiety

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Sex Hormones and Macronutrient Metabolism

Cited by 66 publications

References 176 publications

General and Abdominal Obesity Is Related to Physical Activity, Smoking and Sleeping Behaviours and Mediated by the Educational Level: Findings from the ANIBES Study in Spain

General and Abdominal Obesity Is Related to Physical Activity, Smoking and Sleeping Behaviours and Mediated by the Educational Level: Findings from the ANIBES Study in Spain

The phytoestrogen prunetin affects body composition and improves fitness and lifespan in maleDrosophila melanogaster

Progesterone and plasma metabolites in women with and in those without premenstrual dysphoric disorder

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