Sex Hormones and Coronary Artery Disease

Chute, Christopher G.; Baron, John A.; Plymate, Stephen R.; Kiel, DP; Pavia, Andrew T.; Lozner, Eugene C.; O’Keefe, Thomas J.; MacDonald, G.J.

doi:10.1016/s0022-5347(17)42572-9

Cited by 9 publications

(10 citation statements)

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“…This may be partly due to production of monocytk; chemcattractants. 248 - 247 These data indicate that IL-1 could be involved in the atherogenic process. It has recently been demonstrated that IL-1 can directly stimulate PGE 2 , PGI 2 , and PGF^ synthesis as well as proliferation of human smooth muscle cells.…”

Section: Lnterleukln-1mentioning

confidence: 75%

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Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.

1989

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Section: Lnterleukln-1mentioning

confidence: 75%

“…In addition, the influence of gender and gonadal steroids in improving cardiovascular risk is equivocal. 248 Indeed, no gender difference in human arterial eicosanoid synthesis has been identified; thus, further investigation in this area is required.…”

Section: Gonadal Steroidsmentioning

confidence: 99%

Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.

1989

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“…35 Although a previously reported cross-sectional association between levels of testosterone and CHD was reduced after controlling for levels of triglycerides, 17 others have found that the association is independent of HDL cholesterol levels. 46 Our findings concerning the interrelations among levels of testosterone, HDL cholesterol, cigarette smoking, and obesity emphasize the importance of multivariable analyses in studies that examine the relation of testosterone levels to CHD.…”

Section: " 19mentioning

confidence: 77%

Relation of serum testosterone levels to high density lipoprotein cholesterol and other characteristics in men.

Freedman

O'Brien

Flanders

et al. 1991

Arterioscler Thromb

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Although levels of high density lipoprotein (HDL) cholesterol in males decrease during adolescence and after treatment with testosterone derivatives, several studies have reported that levels of HDL cholesterol are positively associated with endogenous levels of testosterone in men. This association was further examined using data collected during 1985 and 1986 from 3,562 white and 500 black men who ranged in age from 31 to 45 years. Black men had higher mean levels of both HDL cholesterol (8 mg/dl) and total testosterone (33 ng/dl) than white men, and positive associations were observed between testosterone and HDL cholesterol levels (r=0.22, whites; r=0.26, blacks). In addition, levels of testosterone were related positively to alcohol consumption and cigarette smoking and negatively to age, Quetelet index, and use of 0-blockers. We used stratification and regression analyses to determine if any of these characteristics could account for the positive association between levels of HDL cholesterol and total testosterone. Although controlling for most factors had little influence, adjusting for Quetelet index reduced the strength of the association between levels of testosterone and HDL cholesterol by approximately 30%. These findings suggest that the positive association between levels of testosterone and HDL cholesterol may not be causal. Multivariable analyses that control for obesity and other potentially confounding characteristics should be used in studies that assess the relation of testosterone levels to coronary heart disease. (Arteriosclerosis and Thrombosis 1991;ll:307-315)

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“…Significant inverse correlations between testosterone concentration and both the presence and the severity of coronary artery disease have been found in coronary angiographic studies to detect atheroma (14,15). A recent study from Denmark (16) determined the relation-ship between low concentrations of testosterone and acute ischemic stroke.…”

mentioning

confidence: 99%

Association Between Serum Testosterone Concentration and Carotid Atherosclerosis in Men With Type 2 Diabetes

Fukui¹,

Kitagawa²,

Nakamura

et al. 2003

Diabetes Care

106

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OBJECTIVE -There is evidence to suggest that low concentrations of testosterone are associated with an increased risk of cardiovascular disease in men. The aim of this study was to evaluate the relationship between serum testosterone concentration and carotid atherosclerosis as well as major cardiovascular risk factors in men with type 2 diabetes.RESEARCH DESIGN AND METHODS -Serum free and total testosterone concentrations were measured in 253 consecutive men with type 2 diabetes. The relationships between serum testosterone concentration and carotid atherosclerosis, determined by ultrasonographically evaluated intima-media thickness (IMT) and plaque score (PS) in a subgroup of 154 diabetic patients, as well as major cardiovascular risk factors, including age, blood pressure, and lipid concentrations, were evaluated.RESULTS -Inverse correlations were found between free testosterone (F-tes) concentration and IMT (r ϭ Ϫ0.206, P ϭ 0.0103) and between F-tes concentration and PS (r ϭ Ϫ0.334, P Ͻ 0.001). The IMT and PS were significantly greater in patients with lower concentrations of F-tes (Ͻ10 pg/ml) than in patients with higher concentrations of F-tes (1.01 Ϯ 0.29 vs. 0.91 Ϯ 0.26 mm, P ϭ 0.038; 4.5 Ϯ 3.8 vs. 2.4 Ϯ 3.2, P ϭ 0.0003; respectively). An inverse correlation was found between serum F-tes concentration and age (r ϭ Ϫ0.420, P Ͻ 0.0001). A positive correlation was found between serum F-tes and total cholesterol concentrations (r ϭ 0.145, P ϭ 0.0238).CONCLUSIONS -Serum F-tes concentration is inversely associated with carotid atherosclerosis determined by ultrasonographically evaluated IMT and PS in men with type 2 diabetes.

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Sex Hormones and Coronary Artery Disease

Cited by 9 publications

References 0 publications

Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.

Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.

Relation of serum testosterone levels to high density lipoprotein cholesterol and other characteristics in men.

Association Between Serum Testosterone Concentration and Carotid Atherosclerosis in Men With Type 2 Diabetes

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